3LAU
Crystal Structure of Aurora2 kinase in complex with a GSK3beta inhibitor
Summary for 3LAU
Entry DOI | 10.2210/pdb3lau/pdb |
Descriptor | Serine/threonine-protein kinase 6, N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]butanamide (3 entities in total) |
Functional Keywords | kinase inhibitor complex, atp-binding, cell cycle, cytoplasm, cytoskeleton, kinase, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, ubl conjugation |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965 |
Total number of polymer chains | 1 |
Total formula weight | 33637.51 |
Authors | Maignan, S.,Guilloteau, J.P.,Pouzieux, S. (deposition date: 2010-01-07, release date: 2010-03-02, Last modification date: 2023-09-06) |
Primary citation | Lesuisse, D.,Dutruc-Rosset, G.,Tiraboschi, G.,Dreyer, M.K.,Maignan, S.,Chevalier, A.,Halley, F.,Bertrand, P.,Burgevin, M.C.,Quarteronet, D.,Rooney, T. Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg.Med.Chem.Lett., 20:1985-1989, 2010 Cited by PubMed: 20167481DOI: 10.1016/j.bmcl.2010.01.114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)