PDB: 1143 件ウェブページステータス検索Chemie searchBIRD

---

3G0Y	Structure of E. coli FabF(C163Q) in complex with dihydroplatensimycin 分子名称: 3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxodecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2 著者 Soisson, S.M, Parthasarathy, G. 登録日 2009-01-29 公開日 2009-03-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Synthesis and biological evaluation of platensimycin analogs. Bioorg.Med.Chem.Lett., 19, 2009
3G11	Structure of E. coli FabF(C163Q) in complex with dihydrophenyl platensimycin 分子名称: 3-({3-[(1S,4S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxo-4-phenyldecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2 著者 Soisson, S.M, Parthasarathy, G. 登録日 2009-01-29 公開日 2009-03-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Synthesis and biological evaluation of platensimycin analogs. Bioorg.Med.Chem.Lett., 19, 2009
1CX2	CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A SELECTIVE INHIBITOR, SC-558 分子名称: 1-PHENYLSULFONAMIDE-3-TRIFLUOROMETHYL-5-PARABROMOPHENYLPYRAZOLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOOXYGENASE-2, ... 著者 Kurumbail, R, Stallings, W. 登録日 1996-12-17 公開日 1997-12-24 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature, 384, 1996
3MQE	Structure of SC-75416 bound at the COX-2 active site 分子名称: (2S)-7-tert-butyl-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Wang, J.L, Limburg, D, Graneto, M.J, Springer, J, Rogier, J, Kiefer, J.R. 登録日 2010-04-28 公開日 2010-10-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life. Bioorg.Med.Chem.Lett., 20, 2010
3HO2	Structure of E.coli FabF(C163A) in complex with Platencin 分子名称: 2,4-dihydroxy-3-({3-[(2S,4aS,8S,8aR)-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonaphthalen-8-yl]propanoyl}amino)benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2 著者 Soisson, S.M, Parthasarathy, G. 登録日 2009-06-01 公開日 2010-02-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis. Bioorg.Med.Chem.Lett., 19, 2009
2X3E	Crystal structure of 3-oxoacyl-(acyl carrier protein) synthase III, FabH from Pseudomonas aeruginosa PAO1 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 3 著者 Oke, M, Carter, L.G, Johnson, K.A, Liu, H, Mcmahon, S.A, White, M.F, Naismith, J.H. 登録日 2010-01-24 公開日 2010-07-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 The Scottish Structural Proteomics Facility: Targets, Methods and Outputs. J.Struct.Funct.Genomics, 11, 2010
3HO9	Structure of E.coli FabF(C163A) in complex with Platencin A1 分子名称: 2,4-dihydroxy-3-({3-[(2R,4aR,8S,8aR,9R)-9-hydroxy-8-methyl-3-methylidene-7-oxo-1,3,4,7,8,8a-hexahydro-2H-2,4a-ethanonap hthalen-8-yl]propanoyl}amino)benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2 著者 Soisson, S.M, Parthasarathy, G. 登録日 2009-06-01 公開日 2010-02-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis. Bioorg.Med.Chem.Lett., 19, 2009
6B2R	Crystal structure of Xanthomonas campestris OleA H285A 分子名称: 3-oxoacyl-[ACP] synthase III, GLYCEROL 著者 Jensen, M.R, Goblirsch, B.R, Esler, M.A, Christenson, J.K, Mohamed, F.A, Wackett, L.P, Wilmot, C.M. 登録日 2017-09-20 公開日 2018-02-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 The role of OleA His285 in orchestration of long-chain acyl-coenzyme A substrates. FEBS Lett., 592, 2018
6B2S	Crystal structure of Xanthomonas campestris OleA H285N 分子名称: 3-oxoacyl-[ACP] synthase III, GLYCEROL, PHOSPHATE ION 著者 Jensen, M.R, Goblirsch, B.R, Esler, M.A, Christenson, J.K, Mohamed, F.A, Wackett, L.P, Wilmot, C.M. 登録日 2017-09-20 公開日 2018-02-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The role of OleA His285 in orchestration of long-chain acyl-coenzyme A substrates. FEBS Lett., 592, 2018
3I8P	Crystal structure of E. coli FabF(C163A) in complex with Platensimycin A1 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Platensimycin A1 著者 Soisson, S.M, Parthsarathy, G. 登録日 2009-07-09 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis. Bioorg.Med.Chem.Lett., 19, 2009
4RZQ	Structural Analysis of Substrate, Reaction Intermediate and Product Binding in Haemophilus influenzae Biotin Carboxylase 分子名称: ADENOSINE-5'-DIPHOSPHATE, Biotin carboxylase, methyl (3aS,4S,6aR)-4-(5-methoxy-5-oxopentyl)-2-oxohexahydro-1H-thieno[3,4-d]imidazole-1-carboxylate 著者 Broussard, T.C, Pakhomova, S, Neau, D.B, Champion, T.S, Bonnot, R, Waldrop, G.L. 登録日 2014-12-23 公開日 2015-06-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structural Analysis of Substrate, Reaction Intermediate, and Product Binding in Haemophilus influenzae Biotin Carboxylase. Biochemistry, 54, 2015
8HZ5	The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus 分子名称: Biotin carboxylase 著者 Shen, J, Wu, W, Xu, X. 登録日 2023-01-08 公開日 2024-01-10 最終更新日 2024-07-24 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity. Mbio, 15, 2024
1P44	Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data 分子名称: 5-{[4-(9H-FLUOREN-9-YL)PIPERAZIN-1-YL]CARBONYL}-1H-INDOLE, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Kuo, M.R, Morbidoni, H.R, Alland, D, Sneddon, S.F, Gourlie, B.B, Staveski, M.M, Leonard, M, Gregory, J.S, Janjigian, A.D, Yee, C, Musser, J.M, Kreiswirth, B, Iwamoto, H, Perozzo, R, Jacobs Jr, W.R, Sacchettini, J.C, Fidock, D.A, TB Structural Genomics Consortium (TBSGC) 登録日 2003-04-21 公開日 2003-09-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data. J.Biol.Chem., 278, 2003
8QM1	wild type Pa.FabF in complex cerulenin 分子名称: (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, 3-oxoacyl-[acyl-carrier-protein] synthase 2, ... 著者 Georgiou, C, Brenk, R, Espeland, L.O. 登録日 2023-09-21 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
2W6N	Crystal structure of Biotin carboxylase from E. coli in complex with amino-oxazole fragment series 分子名称: 2-AMINO-N,N-BIS(PHENYLMETHYL)-1,3-OXAZOLE-5-CARBOXAMIDE, BIOTIN CARBOXYLASE, CHLORIDE ION 著者 Mochalkin, I, Miller, J.R. 登録日 2008-12-18 公開日 2009-05-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
6CHJ	Wax ester synthase/diacylglycerol acyltransferase from Marinobacter aquaeolei VT8 分子名称: CHLORIDE ION, Diacylglycerol O-acyltransferase 著者 Petronikolou, N, Satish, S.K. 登録日 2018-02-22 公開日 2018-06-13 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.428 Å) 主引用文献 Structural and Biochemical Studies of a Biocatalyst for the Enzymatic Production of Wax Esters. Acs Catalysis, 8, 2018
2W6Q	Crystal structure of Biotin carboxylase from E. coli in complex with the triazine-2,4-diamine fragment 分子名称: 6-(2-phenoxyethoxy)-1,3,5-triazine-2,4-diamine, BIOTIN CARBOXYLASE, CHLORIDE ION 著者 Mochalkin, I, Miller, J.R. 登録日 2008-12-18 公開日 2009-05-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2W71	Crystal structure of Biotin carboxylase from E. coli in complex with the imidazole-pyrimidine inhibitor 分子名称: 4-[1-(2,6-dichlorobenzyl)-2-methyl-1H-imidazol-4-yl]pyrimidin-2-amine, BIOTIN CARBOXYLASE, CHLORIDE ION 著者 Mochalkin, I, Miller, J.R. 登録日 2008-12-19 公開日 2009-05-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
6UIA	Structure of ATP citrate lyase with CoA in a partially open conformation 分子名称: ATP-citrate synthase, COENZYME A 著者 Wei, X, Marmorstein, R. 登録日 2019-09-30 公開日 2019-12-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Molecular basis for acetyl-CoA production by ATP-citrate lyase. Nat.Struct.Mol.Biol., 27, 2020
6UUZ	Structure of ACLY in the presence of citrate and CoA 分子名称: ATP-citrate synthase, COENZYME A 著者 Xuepeng, W, Ronen, M. 登録日 2019-11-01 公開日 2020-01-01 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Molecular basis for acetyl-CoA production by ATP-citrate lyase. Nat.Struct.Mol.Biol., 27, 2020
2W70	Crystal structure of Biotin carboxylase from E. coli in complex with the amino-thiazole-pyrimidine fragment 分子名称: 4-(2-amino-1,3-thiazol-4-yl)pyrimidin-2-amine, BIOTIN CARBOXYLASE, CHLORIDE ION 著者 Mochalkin, I, Miller, J.R. 登録日 2008-12-19 公開日 2009-05-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
6POE	Structure of ACLY in complex with CoA 分子名称: ATP-citrate synthase, COENZYME A 著者 Wei, X, Marmorstein, R. 登録日 2019-07-03 公開日 2019-12-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Molecular basis for acetyl-CoA production by ATP-citrate lyase. Nat.Struct.Mol.Biol., 27, 2020
5MLK	Biotin dependent carboxylase AccA3 dimer from Mycobacterium tuberculosis (Rv3285) 分子名称: Acetyl-COA carboxylase 著者 Bennett, M.D, Hogbom, M. 登録日 2016-12-07 公開日 2017-03-08 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.939 Å) 主引用文献 Crystal structure of the essential biotin-dependent carboxylase AccA3 from Mycobacterium tuberculosis. FEBS Open Bio, 7, 2017
2RCM	Crystal Structure of Arabidopsis thaliana Allene Oxide Synthase variant (F137L) (At-AOS(F137L), cytochrome P450 74A) at 1.73 A Resolution 分子名称: Cytochrome P450 74A, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE 著者 Lee, D.S, Nioche, P, Raman, C.S. 登録日 2007-09-20 公開日 2008-08-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes. Nature, 455, 2008
3QMO	X-ray crystal structure of NS-398 bound to the cyclooxygenase channel of cyclooxygenase-2 分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Vecchio, A.J, Malkowski, M.G. 登録日 2011-02-04 公開日 2011-08-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The structure of NS-398 bound to cyclooxygenase-2. J.Struct.Biol., 176, 2011

<25262728293031323334353637383940>