7DQE
 
 | | Crystal structure of the ADP-bound mutant A(S23C)3B(N64C)3 complex from enterococcus hirae V-ATPase | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Maruyama, S, Nakamoto, K, Suzuki, K, Mizutani, K, Imai, F.L, Ishizuka-Katsura, Y, Shirouzu, M, Murata, T. | | 登録日 | 2020-12-23 | | 公開日 | 2021-12-29 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.694 Å) | | 主引用文献 | The Combination of High-Speed AFM and X-ray Crystallography Reveals Rotary Catalytic Mechanism of Shaftless V1-ATPase
To Be Published
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7DQC
 | | Crystal structure of nucleotide-free mutant A(S23C)3B(N64C)3 complex from Enterococcus hirae V-ATPase | | 分子名称: | GLYCEROL, V-type sodium ATPase catalytic subunit A, V-type sodium ATPase subunit B | | 著者 | Maruyama, S, Suzuki, K, Mizutani, K, Imai, F.L, Ishizuka-Katsura, Y, Shirouzu, M, Murata, M. | | 登録日 | 2020-12-23 | | 公開日 | 2021-12-29 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.706 Å) | | 主引用文献 | The combination of high-speed AFM and X-ray crystallography reveals rotary catalytic mechanism of shaftless V1-ATPase
To Be Published
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6HXH
 | | Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase,Human ATP citrate lyase, CITRATE ANION, ... | | 著者 | Verstraete, K, Verschueren, K. | | 登録日 | 2018-10-17 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
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1H8F
 | | Glycogen Synthase Kinase 3 beta. | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCOGEN SYNTHASE KINASE-3 BETA | | 著者 | Dajani, R, Pearl, L.H, Roe, S.M. | | 登録日 | 2001-02-05 | | 公開日 | 2002-01-31 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structure of Glycogen Synthase Kinase 3Beta . Structural Basis for Phosphate-Primed Substrate Specificity and Autoinhibition
Cell(Cambridge,Mass.), 105, 2001
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3M1S
 | | Structure of Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3 | | 分子名称: | Glycogen synthase kinase-3 beta, Ruthenium pyridocarbazole | | 著者 | Atilla-Gokcumen, G.E, Di Costanzo, L, Zimmermann, G, Meggers, E. | | 登録日 | 2010-03-05 | | 公開日 | 2010-12-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.134 Å) | | 主引用文献 | Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3beta
J.Biol.Inorg.Chem., 16, 2011
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5T31
 | | Exploiting an Asp-Glu switch in Glycogen Synthase Kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia | | 分子名称: | (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta | | 著者 | Stein, A.J, Holson, E.B, Wagner, F.F, Cambell, A.J. | | 登録日 | 2016-08-24 | | 公開日 | 2018-02-21 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.
Sci Transl Med, 10, 2018
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2OW3
 | | Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor | | 分子名称: | BIS-(INDOLE)MALEIMIDE PYRIDINOPHANE, Glycogen synthase kinase-3 beta | | 著者 | Zhang, H.C, Bonaga, L.V, Ye, H, Derian, C.K, Damiano, B.P, Maryanoff, B.E. | | 登録日 | 2007-02-15 | | 公開日 | 2008-02-19 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3.
Bioorg.Med.Chem.Lett., 17, 2007
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3ZDI
 | | Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d | | 分子名称: | 3,6-Diamino-4-(2-chlorophenyl)thieno[2,3-b]pyridine-2,5-dicarbonitrile, AXIN-1, GLYCOGEN SYNTHASE KINASE-3 BETA, ... | | 著者 | Oberholzer, A.E, Pearl, L.H. | | 登録日 | 2012-11-27 | | 公開日 | 2012-12-26 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.645 Å) | | 主引用文献 | 3,6-Diamino-4-(2-Halophenyl)-2-Benzoylthieno(2,3-B) Pyridine-5-Carbonitriles are Selective Inhibitors of Plasmodium Falciparum Glycogen Synthase Kinase-3 (Pfgsk-3)
J.Med.Chem., 56, 2013
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6HXL
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6HXJ
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6B8J
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6HXK
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7RMC
 | | Yeast CTP Synthase (Ura7) filament bound to CTP at low pH | | 分子名称: | CTP synthase 1, CYTIDINE-5'-TRIPHOSPHATE | | 著者 | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | | 登録日 | 2021-07-27 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
Elife, 10, 2021
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2MX1
 | | Structure of the E. coli Threonylcarbamoyl-AMP Synthase TSAC | | 分子名称: | Threonylcarbamoyl-AMP synthase | | 著者 | Harris, K.A, Bobay, B.G, Sarachan, K.L, Sims, A.F, Bilbille, Y, Deutsch, C, Iwata-Reuyl, D, Agris, P.F. | | 登録日 | 2014-12-06 | | 公開日 | 2015-06-17 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR-based Structural Analysis of Threonylcarbamoyl-AMP Synthase and Its Substrate Interactions.
J.Biol.Chem., 290, 2015
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4O7W
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2Z02
 | | Crystal structure of phosphoribosylaminoimidazolesuccinocarboxamide synthase wit ATP from Methanocaldococcus jannaschii | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CITRIC ACID, Phosphoribosylaminoimidazole-succinocarboxamide synthase, ... | | 著者 | Kanagawa, M, Baba, S, Kuramitsu, S, Yokoyama, S, Kawai, G, Sampei, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-05-06 | | 公開日 | 2007-11-06 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Crystal structure of phosphoribosylaminoimidazolesuccinocarboxamide synthase from Methanocaldococcus jannaschii
To be Published
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4C1N
 | | Corrinoid protein reactivation complex with activator | | 分子名称: | CARBON MONOXIDE DEHYDROGENASE CORRINOID/IRON-SULFUR PROTEIN, GAMMA SUBUNIT, CO DEHYDROGENASE/ACETYL-COA SYNTHASE, ... | | 著者 | Hennig, S.E, Goetzl, S, Jeoung, J.H, Bommer, M, Lendzian, F, Hildebrandt, P, Dobbek, H. | | 登録日 | 2013-08-13 | | 公開日 | 2014-08-13 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | | 主引用文献 | ATP-Induced Electron Transfer by Redox-Selective Partner Recognition
Nat.Commun., 5, 2014
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8SBR
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7FDC
 | | CryoEM Structures of Reconstituted V-ATPase, state3 | | 分子名称: | Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT), V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | | 著者 | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | | 登録日 | 2021-07-16 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | | 主引用文献 | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation.
Embo J., 2021
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7FDA
 | | CryoEM Structure of Reconstituted V-ATPase, state1 | | 分子名称: | Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT), V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | | 著者 | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | | 登録日 | 2021-07-16 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation.
Embo J., 2021
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7FDB
 | | CryoEM Structures of Reconstituted V-ATPase,State2 | | 分子名称: | Fusion of yeast V-type proton ATPase subunit H(NT) and human V-type proton ATPase subunit H(CT), V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | | 著者 | Khan, M.M, Lee, S, Oot, R.A, Couoh-Cardel, S, KIm, H, Wilkens, S, Roh, S.H. | | 登録日 | 2021-07-16 | | 公開日 | 2021-12-22 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | CryoEM Structures of Reconstituted V-ATPase and Oxr1-bound V1 Reveal a Novel Mechanism of Regulation.
Embo J., 2021
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1VDZ
 | | Crystal structure of A-type ATPase catalytic subunit A from Pyrococcus horikoshii OT3 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, A-type ATPase subunit A | | 著者 | Maegawa, Y, Morita, H, Yao, M, Watanabe, N, Tanaka, I. | | 登録日 | 2004-03-26 | | 公開日 | 2005-06-21 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Crystal structure of A-type ATPase catalytic subunit A from Pyrococcus horikoshii OT3
To be Published
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4XJ4
 | | Crystal structure of Vibrio cholerae DncV 3'-deoxy ATP bound form | | 分子名称: | 1,2-ETHANEDIOL, 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, Cyclic AMP-GMP synthase, ... | | 著者 | Kato, K, Ishii, R, Ishitani, R, Nureki, O. | | 登録日 | 2015-01-08 | | 公開日 | 2015-04-29 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.596 Å) | | 主引用文献 | Structural Basis for the Catalytic Mechanism of DncV, Bacterial Homolog of Cyclic GMP-AMP Synthase
Structure, 23, 2015
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6HXO
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8FV6
 | | E coli. CTP synthase in complex with dF-dCTP | | 分子名称: | 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), CTP synthase, MALONIC ACID, ... | | 著者 | Holyoak, T, McLeod, M.J, Tran, N. | | 登録日 | 2023-01-18 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Protein Sci., 32, 2023
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