PDB: 42091 件ウェブページステータス検索Chemie searchBIRD

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6I84	Structure of transcribing RNA polymerase II-nucleosome complex 分子名称: DNA (158-MER), DNA (170-MER), DNA-directed RNA polymerase II subunit RPB1, ... 著者 Farnung, L, Vos, S.M, Cramer, P. 登録日 2018-11-19 公開日 2019-01-02 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Structure of transcribing RNA polymerase II-nucleosome complex. Nat Commun, 9, 2018
5Y0D	Crystal Structure of the human nucleosome containing the H2B E76K mutant 分子名称: CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... 著者 Kurumizaka, H, Arimura, Y, Fujita, R, Noda, M. 登録日 2017-07-16 公開日 2018-07-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. Nucleic Acids Res., 46, 2018
5KGF	Structural model of 53BP1 bound to a ubiquitylated and methylated nucleosome, at 4.5 A resolution 分子名称: DNA (145-MER), Histone H2A type 1, Histone H2B type 1-C/E/F/G/I, ... 著者 Wilson, M.D, Benlekbir, S, Sicheri, F, Rubinstein, J.L, Durocher, D. 登録日 2016-06-13 公開日 2016-07-27 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (4.54 Å) 主引用文献 The structural basis of modified nucleosome recognition by 53BP1. Nature, 536, 2016
3E0Q	Crystal structure of Schistosoma mansoni purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor 分子名称: 6-amino-5-bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione, DIMETHYL SULFOXIDE, Purine-nucleoside phosphorylase 著者 Pereira, H.M, Berdini, V, Ferri, M.R, Cleasby, A, Garratt, R.C. 登録日 2008-07-31 公開日 2009-08-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of Schistosoma purine nucleoside phosphorylase complexed with a novel monocyclic inhibitor. Acta Trop., 114, 2010
6R1T	Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 1, free nuclesome 分子名称: DNA (147-MER), HISTONE H2A, Histone H2A, ... 著者 Marabelli, C, Pilotto, S, Chittori, S, Subramaniam, S, Mattevi, A. 登録日 2019-03-15 公開日 2019-04-24 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.02 Å) 主引用文献 A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep, 27, 2019
4RW9	Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor 分子名称: (2E)-3-(3-chloro-5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile, Reverse transcriptase/ribonuclease H, p51 subunit, ... 著者 Frey, K.M, Anderson, K.S. 登録日 2014-12-01 公開日 2015-04-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.986 Å) 主引用文献 Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants. J.Med.Chem., 58, 2015
4RW6	Crystal Structure of HIV-1 Reverse Transcriptase (Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor 分子名称: (2E)-3-(3-chloro-5-{4-chloro-2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile, Reverse transcriptase/ribonuclease H, p51 subunit, ... 著者 Frey, K.M, Anderson, K.S. 登録日 2014-12-01 公開日 2015-04-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.631 Å) 主引用文献 Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants. J.Med.Chem., 58, 2015
6GEN	Chromatin remodeller-nucleosome complex at 4.5 A resolution. 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-like protein ARP6, BERYLLIUM TRIFLUORIDE ION, ... 著者 Willhoft, O, Chua, E.Y.D, Wilkinson, M, Wigley, D.B. 登録日 2018-04-27 公開日 2018-10-17 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure and dynamics of the yeast SWR1-nucleosome complex. Science, 362, 2018
6GEJ	Chromatin remodeller-nucleosome complex at 3.6 A resolution. 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin-like protein ARP6, BERYLLIUM TRIFLUORIDE ION, ... 著者 Willhoft, O, Chua, E.Y.D, Wilkinson, M, Wigley, D.B. 登録日 2018-04-26 公開日 2018-10-17 最終更新日 2025-07-09 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structure and dynamics of the yeast SWR1-nucleosome complex. Science, 362, 2018
1N3I	Crystal Structure of Mycobacterium tuberculosis PNP with transition state analog DADMe-ImmH 分子名称: 7-[[(3R,4R)-3-(hydroxymethyl)-4-oxidanyl-pyrrolidin-1-ium-1-yl]methyl]-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine Nucleoside Phosphorylase 著者 Lewandowicz, A, Shi, W, Evans, G.B, Tyler, P.C, Furneaux, R.H, Basso, L.A, Santos, D.S, Almo, S.C, Schramm, V.L. 登録日 2002-10-28 公開日 2003-09-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Over-The-Barrier Transition State Analogues Provide New Chemistries for Inhibitor Design: The Case of Purine Nucleoside Phosphorylase BIOCHEMISTRY, 42, 2003
6LAB	169 bp nucleosome, harboring cohesive DNA termini, assembled with linker histone H1.0 分子名称: CALCIUM ION, CHLORIDE ION, DNA (169-MER), ... 著者 Adhireksan, Z, Sharma, D, Bao, Q, Lee, P.L, Padavattan, S, Davey, C.A. 登録日 2019-11-12 公開日 2021-02-17 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Engineering nucleosomes for generating diverse chromatin assemblies. Nucleic Acids Res., 49, 2021
6LA2	343 bp di-nucleosome harboring cohesive DNA termini assembled with linker histone H1.0 分子名称: DNA (343-MER), Histone H1.0, Histone H2A type 1-B/E, ... 著者 Adhireksan, Z, Sharma, D, Lee, P.L, Davey, C.A. 登録日 2019-11-11 公開日 2021-02-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.89 Å) 主引用文献 Engineering nucleosomes for generating diverse chromatin assemblies. Nucleic Acids Res., 49, 2021
4RW7	Crystal Structure of HIV-1 Reverse Transcriptase (K103N, Y181C) variant in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor 分子名称: (2E)-3-(3-chloro-5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile, Reverse transcriptase/ribonuclease H, p51 subunit, ... 著者 Frey, K.M, Anderson, K.S. 登録日 2014-12-01 公開日 2015-04-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.014 Å) 主引用文献 Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants. J.Med.Chem., 58, 2015
3E9Z	Crystal structure of purine nucleoside phosphorylase from Schistosoma mansoni in complex with 6-chloroguanine 分子名称: 6-chloroguanine, ACETATE ION, DIMETHYL SULFOXIDE, ... 著者 Pereira, H.M, Rezende, M.M, Oliva, G, Garratt, R.C. 登録日 2008-08-24 公開日 2009-09-01 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Crystal structure of Schistosoma mansoni purine nucleoside phosphorylase (SmPNP) in complex with adenine, 8-aminoguanine, 8-azaguanine and 6-chloroguanine. To be Published
4RW4	Crystal Structure of HIV-1 Reverse Transcriptase (K103N,Y181C) variant in complex with (E)-3-(3-chloro-5-(4-chloro-2-(2-(2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ494), a Non-nucleoside Inhibitor 分子名称: (2E)-3-(3-chloro-5-{4-chloro-2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile, Reverse transcriptase/ribonuclease H, p51 subunit, ... 著者 Frey, K.M, Anderson, K.S. 登録日 2014-12-01 公開日 2015-04-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.674 Å) 主引用文献 Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants. J.Med.Chem., 58, 2015
4RW8	Crystal Structure of HIV-1 Reverse Transcriptase in complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)phenyl)acrylonitrile (JLJ532), a non-nucleoside inhibitor' 分子名称: (2E)-3-(3-chloro-5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile, Reverse transcriptase/ribonuclease H, p51 subunit, ... 著者 Frey, K.M, Anderson, K.S. 登録日 2014-12-01 公開日 2015-04-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.878 Å) 主引用文献 Structure-Based Evaluation of Non-nucleoside Inhibitors with Improved Potency and Solubility That Target HIV Reverse Transcriptase Variants. J.Med.Chem., 58, 2015
7NKY	RNA Polymerase II-Spt4/5-nucleosome-FACT structure 分子名称: Chromatin elongation factor SPT4, DNA (138-MER), DNA (148-MER), ... 著者 Farnung, L, Ochmann, M, Engeholm, M, Cramer, P. 登録日 2021-02-19 公開日 2021-07-07 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis of nucleosome transcription mediated by Chd1 and FACT. Nat.Struct.Mol.Biol., 28, 2021
7NL0	Cryo-EM structure of the Lin28B nucleosome core particle 分子名称: DNA (131-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... 著者 Roberts, G.A, Ozkan, B, Gachulincova, I, O Dwyer, M.R, Hall-Ponsele, E, Saxena, M, Robinson, P.J, Soufi, A. 登録日 2021-02-19 公開日 2021-08-11 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Dissecting OCT4 defines the role of nucleosome binding in pluripotency. Nat.Cell Biol., 23, 2021
7NKX	RNA polymerase II-Spt4/5-nucleosome-Chd1 structure 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromatin elongation factor SPT4, ... 著者 Farnung, L, Ochmann, M, Engeholm, M, Cramer, P. 登録日 2021-02-19 公開日 2021-08-25 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis of nucleosome transcription mediated by Chd1 and FACT. Nat.Struct.Mol.Biol., 28, 2021
1YRY	Crystal structure of human PNP complexed with MESG 分子名称: 7-METHYL-6-THIO-GUANOSINE, Purine nucleoside phosphorylase, SULFATE ION 著者 Silva, R.G, Pereira, J.H, Canduri, F, Basso, L.A, de Azevedo Jr, W.F, Santos, D.S. 登録日 2005-02-05 公開日 2006-01-17 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Kinetics and crystal structure of human purine nucleoside phosphorylase in complex with 7-methyl-6-thio-guanosine Arch.Biochem.Biophys., 442, 2005
4R5P	Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and a nucleoside triphosphate mimic alpha-carboxy nucleoside phosphonate inhibitor 分子名称: 5'-D(*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3', 5'-D(*TP*GP*GP*AP*CP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*G)-3', HIV-1 reverse transcriptase, ... 著者 Das, K, Martinez, S.E, Arnold, E. 登録日 2014-08-21 公開日 2015-03-11 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (2.894 Å) 主引用文献 Alpha-carboxy nucleoside phosphonates as universal nucleoside triphosphate mimics. Proc.Natl.Acad.Sci.USA, 112, 2015
6L9Z	338 bp di-nucleosome assembled with linker histone H1.X 分子名称: CALCIUM ION, CHLORIDE ION, DNA (338-MER), ... 著者 Adhireksan, Z, Sharma, D, Lee, P.L, Davey, C.A. 登録日 2019-11-11 公開日 2021-02-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Engineering nucleosomes for generating diverse chromatin assemblies. Nucleic Acids Res., 49, 2021
7UND	Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... 著者 Filipovski, M, Vos, S.M, Farnung, L. 登録日 2022-04-10 公開日 2022-10-19 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structural basis of nucleosome retention during transcription elongation. Science, 376, 2022
2DXE	Crystal structure of nucleoside diphosphate kinase in complex with GDP 分子名称: CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Kato-Murayama, M, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-08-25 公開日 2007-02-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of nucleoside diphosphate kinase in complex with GDP To be Published
2DXF	Crystal structure of nucleoside diphosphate kinase in complex with GTP analog 分子名称: CHLORIDE ION, Nucleoside diphosphate kinase, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Kato-Murayama, M, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-08-25 公開日 2007-02-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of nucleoside diphosphate kinase in complex with GTP analog To be Published

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