3RAP
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7Z6L
| Crystal structure of PROTAC 5 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | 分子名称: | (2~{S},4~{R})-~{N}-[[2-[3-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]propoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | 著者 | Roy, M.J, Bader, G, Farnaby, W, Ciulli, A. | 登録日 | 2022-03-12 | 公開日 | 2022-09-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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7Z77
| Crystal structure of compound 6 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | 分子名称: | (2~{S},4~{R})-~{N}-[(1~{S})-4-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]butyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | 著者 | Bader, G, Boettcher, J, Wolkerstorfer, B. | 登録日 | 2022-03-15 | 公開日 | 2022-09-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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7Z76
| Crystal structure of compound 10 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | 分子名称: | (2~{S},4~{R})-~{N}-[(1~{R})-2-[(2~{R})-1-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]propan-2-yl]oxy-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-1-[(2~{S})-2-[[1-(dimethylamino)cyclopropyl]carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | 著者 | Bader, G, Boettcher, J, Wolkerstorfer, B. | 登録日 | 2022-03-15 | 公開日 | 2022-09-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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7Z78
| Crystal structure of compound 4 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | 分子名称: | 4-bromanyl-7-cyclopentyl-9-piperidin-4-yl-benzimidazolo[1,2-a]quinazolin-5-one, Probable global transcription activator SNF2L2, ZINC ION | 著者 | Bader, G, Boettcher, J, Wolkerstorfer, B. | 登録日 | 2022-03-15 | 公開日 | 2022-09-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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2XKA
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3RNJ
| Crystal structure of the SH3 domain from IRSp53 (BAIAP2) | 分子名称: | 1,2-ETHANEDIOL, Brain-specific angiogenesis inhibitor 1-associated protein 2, ISOPROPYL ALCOHOL, ... | 著者 | Simister, P.C, Barilari, M, Muniz, J.R.C, Dente, L, Knapp, S, von Delft, F, Filippakopoulos, P, Vollmar, M, Chaikuad, A, Raynor, J, Tregubova, A, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Feller, S.M, Structural Genomics Consortium (SGC) | 登録日 | 2011-04-22 | 公開日 | 2011-05-04 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of the SH3 domain from IRSp53 (BAIAP2) To be Published
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3R1X
| Crystal structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae | 分子名称: | 2-oxo-3-deoxygalactonate kinase, FORMIC ACID, GLYCEROL | 著者 | Michalska, K, Cuff, M.E, Tesar, C, Feldmann, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2011-03-11 | 公開日 | 2011-04-13 | 最終更新日 | 2011-09-21 | 実験手法 | X-RAY DIFFRACTION (2.093 Å) | 主引用文献 | Structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae. Acta Crystallogr.,Sect.D, 67, 2011
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3R6M
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2EOT
| SOLUTION STRUCTURE OF EOTAXIN, AN ENSEMBLE OF 32 NMR SOLUTION STRUCTURES | 分子名称: | EOTAXIN | 著者 | Crump, M.P, Rajarathnam, K, Kim, K.-S, Clark-Lewis, I, Sykes, B.D. | 登録日 | 1998-06-29 | 公開日 | 1998-11-11 | 最終更新日 | 2022-03-09 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation. J.Biol.Chem., 273, 1998
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2HW4
| Crystal structure of human phosphohistidine phosphatase | 分子名称: | 14 kDa phosphohistidine phosphatase, FORMIC ACID | 著者 | Busam, R.D, Thorsell, A.G, Arrowsmith, C, Berglund, H, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Holmberg Schiavone, L, Hogbom, M, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Ogg, D, Stenmark, P, Sundstrom, M, Uppenberg, J, Van Den Berg, S, Weigelt, J, Persson, C, Hallberg, B.M, Structural Genomics Consortium (SGC) | 登録日 | 2006-07-31 | 公開日 | 2006-08-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | First structure of a eukaryotic phosphohistidine phosphatase J.Biol.Chem., 281, 2006
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2D9Q
| Crystal Structure of the Human GCSF-Receptor Signaling Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CSF3, Granulocyte colony-stimulating factor receptor | 著者 | Tamada, T, Kuroki, R. | 登録日 | 2005-12-12 | 公開日 | 2006-02-07 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex Proc.Natl.Acad.Sci.Usa, 103, 2006
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2VX6
| CELLVIBRIO JAPONICUS MANNANASE CJMAN26C Gal1Man4-BOUND FORM | 分子名称: | CELLVIBRIO JAPONICUS MANNANASE CJMAN26C, SODIUM ION, beta-D-mannopyranose-(1-4)-[alpha-D-galactopyranose-(1-6)]beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-beta-D-mannopyranose | 著者 | Cartmell, A, Topakas, E, Ducros, V.M.-A, Suits, M.D.L, Davies, G.J, Gilbert, H.J. | 登録日 | 2008-07-01 | 公開日 | 2008-09-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | The Cellvibrio Japonicus Mannanase Cjman26C Displays a Unique Exo-Mode of Action that is Conferred by Subtle Changes to the Distal Region of the Active Site. J.Biol.Chem., 283, 2008
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2VX7
| CELLVIBRIO JAPONICUS MANNANASE CJMAN26C MANNOBIOSE-BOUND FORM | 分子名称: | CELLVIBRIO JAPONICUS MANNANASE CJMAN26C, SODIUM ION, beta-D-mannopyranose-(1-4)-beta-D-mannopyranose | 著者 | Cartmell, A, Topakas, E, Ducros, V.M.-A, Suits, M.D.L, Davies, G.J, Gilbert, H.J. | 登録日 | 2008-07-01 | 公開日 | 2008-09-16 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The Cellvibrio Japonicus Mannanase Cjman26C Displays a Unique Exo-Mode of Action that is Conferred by Subtle Changes to the Distal Region of the Active Site. J.Biol.Chem., 283, 2008
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6TEK
| Structure of siderophore interaction domain of IrtAB | 分子名称: | Drug ABC transporter ATP-binding protein, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Arnold, F.M, Gonda, I, Hutter, C.A.J, Seeger, M.A, Hurlimann, L.M. | 登録日 | 2019-11-12 | 公開日 | 2020-04-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The ABC exporter IrtAB imports and reduces mycobacterial siderophores. Nature, 580, 2020
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6TEJ
| Structure of apo IrtAB devoid SID in complex with sybody Syb_NL5 | 分子名称: | DECYL-BETA-D-MALTOPYRANOSIDE, Drug ABC transporter ATP-binding protein, NICKEL (II) ION, ... | 著者 | Gonda, I, Arnold, F.M, Hutter, C.A.J, Weber, M.S, Seeger, M.A, Hurlimann, L.M. | 登録日 | 2019-11-12 | 公開日 | 2020-04-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The ABC exporter IrtAB imports and reduces mycobacterial siderophores. Nature, 580, 2020
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1OZI
| The alternatively spliced PDZ2 domain of PTP-BL | 分子名称: | protein tyrosine phosphatase | 著者 | Walma, T, Aelen, J, Oostendorp, M, van den Berk, L, Hendriks, W, Vuister, G.W. | 登録日 | 2003-04-09 | 公開日 | 2004-01-27 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | A Closed Binding Pocket and Global Destabilization Modify the Binding Properties of an Alternatively Spliced Form of the Second PDZ Domain of PTP-BL. Structure, 12, 2004
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2LW9
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2P0A
| The crystal structure of human synapsin III (SYN3) in complex with AMPPNP | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Turnbull, A.P, Phillips, C, Pike, A.C.W, Elkins, J.M, Gileadi, C, Salah, E, Niesen, F.H, Burgess, N, Gileadi, O, Gorrec, F, Umeano, C, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C.H, Sundstrom, M, Doyle, D, Structural Genomics Consortium (SGC) | 登録日 | 2007-02-28 | 公開日 | 2007-03-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The crystal structure of human synapsin III (SYN3) in complex with AMPPNP To be Published
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2J5X
| STRUCTURE OF THE SMALL G PROTEIN ARF6 IN COMPLEX WITH GTPGAMMAS | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADP-RIBOSYLATION FACTOR 6, MAGNESIUM ION | 著者 | Pasqualato, S, Menetrey, J, Franco, M, Cherfils, J. | 登録日 | 2006-09-20 | 公開日 | 2006-09-21 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The Structural Gdp-GTP Cycle of Human Arf6. Embo Rep., 2, 2001
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5Y3T
| Crystal structure of hetero-trimeric core of LUBAC: HOIP double-UBA complexed with HOIL-1L UBL and SHARPIN UBL | 分子名称: | E3 ubiquitin-protein ligase RNF31, GLYCEROL, RanBP-type and C3HC4-type zinc finger-containing protein 1, ... | 著者 | Tokunaga, A, Fujita, H, Ariyoshi, M, Ohki, I, Tochio, H, Iwai, K, Shirakawa, M. | 登録日 | 2017-07-31 | 公開日 | 2018-05-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization. Cell Rep, 23, 2018
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6M3P
| Crystal structure of AnkG/beta2-spectrin complex | 分子名称: | Ankyrin-3, Spectrin beta chain, non-erythrocytic 1 | 著者 | Li, J, Chen, K, Zhu, R, Zhang, M. | 登録日 | 2020-03-04 | 公開日 | 2020-05-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.312 Å) | 主引用文献 | Structural Basis Underlying Strong Interactions between Ankyrins and Spectrins. J.Mol.Biol., 432, 2020
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2PFV
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2PFT
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6M3R
| Crystal structure of AnkG/beta4-spectrin complex | 分子名称: | Ankyrin-3, Spectrin beta chain | 著者 | Li, J, Chen, K, Zhu, R, Zhang, M. | 登録日 | 2020-03-04 | 公開日 | 2020-05-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (4.313 Å) | 主引用文献 | Structural Basis Underlying Strong Interactions between Ankyrins and Spectrins. J.Mol.Biol., 432, 2020
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