5Y3T

Crystal structure of hetero-trimeric core of LUBAC: HOIP double-UBA complexed with HOIL-1L UBL and SHARPIN UBL

Summary for 5Y3T

Entry DOI	10.2210/pdb5y3t/pdb
Descriptor	RanBP-type and C3HC4-type zinc finger-containing protein 1, E3 ubiquitin-protein ligase RNF31, Sharpin, ... (5 entities in total)
Functional Keywords	hoip, hoil-1l, sharpin, linear-ubiquitin assembly complex, nf-kb activation, lubac tethering motif, lubac stabilization, ligase
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	3
Total formula weight	53771.72
Authors	Tokunaga, A.,Fujita, H.,Ariyoshi, M.,Ohki, I.,Tochio, H.,Iwai, K.,Shirakawa, M. (deposition date: 2017-07-31, release date: 2018-05-02, Last modification date: 2023-11-22)
Primary citation	Fujita, H.,Tokunaga, A.,Shimizu, S.,Whiting, A.L.,Aguilar-Alonso, F.,Takagi, K.,Walinda, E.,Sasaki, Y.,Shimokawa, T.,Mizushima, T.,Ohki, I.,Ariyoshi, M.,Tochio, H.,Bernal, F.,Shirakawa, M.,Iwai, K. Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization. Cell Rep, 23:1192-1204, 2018 Cited by PubMed: 29694895 DOI: 10.1016/j.celrep.2018.03.112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation