5Y3T
Crystal structure of hetero-trimeric core of LUBAC: HOIP double-UBA complexed with HOIL-1L UBL and SHARPIN UBL
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RanBP-type and C3HC4-type zinc finger-containing protein 1 | polymer | 140 | 15763.0 | 1 | UniProt (Q9WUB0) Pfam (PF25393) | Mus musculus (Mouse) | Heme-oxidized IRP2 ubiquitin ligase 1 homolog,HOIL-1,RING-type E3 ubiquitin transferase HOIL-1,UbcM4-interacting protein 28,Ubiquitin-conjugating enzyme 7-interacting protein 3 |
| 2 | B (B) | E3 ubiquitin-protein ligase RNF31 | polymer | 158 | 17995.1 | 1 | UniProt (Q924T7) Pfam (PF16678) | Mus musculus (Mouse) | HOIL-1-interacting protein,HOIP,Putative Ariadne-like ubiquitin ligase,PAUL,RING finger protein 31,RING-type E3 ubiquitin transferase RNF31 |
| 3 | C (C) | Sharpin | polymer | 187 | 19921.5 | 1 | UniProt (Q91WA6) Pfam (PF25393) | Mus musculus (Mouse) | Shank-associated RH domain-interacting protein,Shank-interacting protein-like 1,mSIPL1 |
| 4 | D (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E, F, G (A, B, C) | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
B: 474 - 630 (UniProt: Q924T7)
C: 163 - 341 (UniProt: Q91WA6)
| PDB | External Database | Details |
|---|---|---|
| Gly 473 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 155 | - | expression tag |
| Pro 156 | - | expression tag |
| Leu 157 | - | expression tag |
| Gly 158 | - | expression tag |
| Ser 159 | - | expression tag |
| Pro 160 | - | expression tag |
| Glu 161 | - | expression tag |
| Phe 162 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 53679.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 53771.7 |
