PDB: 19228 件ウェブページステータス検索Chemie searchBIRD

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7R4E	RVX-inhibited acetylcholinesterase in complex with 2-((hydroxyimino)methyl)-1-(5-(4-methyl-3-nitrobenzamido)pentyl)pyridinium 分子名称: 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, 2-(2-METHOXYETHOXY)ETHANOL, 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, ... 著者 Forsgren, N, Lindgren, C, Edvinsson, L, Linusson, A, Ekstrom, F. 登録日 2022-02-08 公開日 2022-04-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.00001168 Å) 主引用文献 Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. Chemistry, 28, 2022
5FSH	Crystal structure of Thermus thermophilus Csm6 分子名称: CSM6, NICKEL (II) ION 著者 Niewoehner, O, Jinek, M. 登録日 2016-01-06 公開日 2016-01-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Structural Basis for the Endoribonuclease Activity of the Type III-A Crispr-Associated Protein Csm6. RNA, 22, 2016
7MQ9	Cryo-EM structure of the human SSU processome, state pre-A1* 分子名称: 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... 著者 Vanden Broeck, A, Singh, S, Klinge, S. 登録日 2021-05-05 公開日 2021-09-22 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.87 Å) 主引用文献 Nucleolar maturation of the human small subunit processome. Science, 373, 2021
7R2F	Structure of tabun inhibited acetylcholinesterase in complex with 2-((hydroxyimino)methyl)-1-(5-(4-methyl-3-nitrobenzamido)pentyl)pyridinium 分子名称: 2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL, 2-(2-METHOXYETHOXY)ETHANOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Forsgren, N, Lindgren, C, Edvinsson, L, Linusson, A, Ekstrom, F. 登録日 2022-02-04 公開日 2022-04-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. Chemistry, 28, 2022
7R0A	Structure of sarin phosphonylated acetylcholinesterase in complex with 2-((hydroxyimino)methyl)-1-(5-(4-methyl-3-nitrobenzamido)pentyl)pyridinium 分子名称: 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, 2-(2-METHOXYETHOXY)ETHANOL, 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, ... 著者 Forsgren, N, Lindgren, C, Edvinsson, L, Linusson, A, Ekstrom, F. 登録日 2022-02-01 公開日 2022-04-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. Chemistry, 28, 2022
5MDW	Structure of ArfA(A18T) and RF2 bound to the 70S ribosome (pre-accommodated state) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 James, N.R, Brown, A, Gordiyenko, Y, Ramakrishnan, V. 登録日 2016-11-13 公開日 2016-12-14 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.06 Å) 主引用文献 Translational termination without a stop codon. Science, 354, 2016
6AU1	Structure of the PgaB (BpsB) glycoside hydrolase domain from Bordetella bronchiseptica 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Putative hemin storage protein, ... 著者 Little, D.J, Bamford, N.C, Howell, P.L. 登録日 2017-08-30 公開日 2018-04-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 PgaB orthologues contain a glycoside hydrolase domain that cleaves deacetylated poly-beta (1,6)-N-acetylglucosamine and can disrupt bacterial biofilms. PLoS Pathog., 14, 2018
7R02	Mus musculus acetylcholinesterase in complex with N-(3-(diethylamino)propyl)-4-methyl-3-nitrobenzamide 分子名称: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, 2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol, ... 著者 Forsgren, N, Lindgren, C, Edvinsson, L, Linusson, A, Ekstrom, F. 登録日 2022-02-01 公開日 2022-04-27 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. Chemistry, 28, 2022
7R3C	VX-inhibited acetylcholinesterase in complex with 2-((hydroxyimino)methyl)-1-(5-(4-methyl-3-nitrobenzamido)pentyl)pyridinium 分子名称: 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, 2-(2-METHOXYETHOXY)ETHANOL, 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, ... 著者 Forsgren, N, Lindgren, C, Edvinsson, L, Linusson, A, Ekstrom, F. 登録日 2022-02-07 公開日 2022-04-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.40000415 Å) 主引用文献 Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. Chemistry, 28, 2022
7MQA	Cryo-EM structure of the human SSU processome, state post-A1 分子名称: 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... 著者 Vanden Broeck, A, Singh, S, Klinge, S. 登録日 2021-05-05 公開日 2021-09-22 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Nucleolar maturation of the human small subunit processome. Science, 373, 2021
6AX4	Plk-1 polo-box domain in complex with histidine N(tau)-cyclized Macrocycle 5b. 分子名称: AMYLAMINE, Serine/threonine-protein kinase PLK1, histidine N(tau)-cyclized Macrocycle 5b 著者 Grant, R.A, Hymel, D, Yaffe, M.B, Burke, T.R. 登録日 2017-09-06 公開日 2018-09-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Histidine N( tau )-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors. Bioorg. Med. Chem. Lett., 28, 2018
7MQ8	Cryo-EM structure of the human SSU processome, state pre-A1 分子名称: 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... 著者 Vanden Broeck, A, Singh, S, Klinge, S. 登録日 2021-05-05 公開日 2021-09-22 最終更新日 2024-08-28 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Nucleolar maturation of the human small subunit processome. Science, 373, 2021
6AYO	Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with 5'-deoxy-5'-Propyl-DADMe-Immucillin-A 分子名称: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-propylpyrrolidin-3-ol, 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... 著者 Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. 登録日 2017-09-08 公開日 2018-09-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase. ACS Chem. Biol., 13, 2018
6AYM	Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) 分子名称: 1,2-ETHANEDIOL, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 著者 Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. 登録日 2017-09-08 公開日 2018-09-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase. ACS Chem. Biol., 13, 2018
6AYS	Crystal structure of Campylobacter jejuni 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with hexylthio-DADMe-Immucillin-A 分子名称: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(hexylsulfanyl)methyl]pyrrolidin-3-ol, 1,2-ETHANEDIOL, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 著者 Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. 登録日 2017-09-08 公開日 2018-09-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase. ACS Chem. Biol., 13, 2018
7MJO	Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 1 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ... 著者 Sung, M.W, Shyng, S.L. 登録日 2021-04-20 公開日 2021-10-13 最終更新日 2022-10-26 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. Proc.Natl.Acad.Sci.USA, 118, 2021
6B1E	The structure of DPP4 in complex with Vildagliptin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{[(1r,3s,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]decan-1-yl]amino}-1-{(2S)-2-[(E)-iminomethyl]pyrrolidin-1-yl}ethan-1-o ne, ... 著者 Scapin, G. 登録日 2017-09-18 公開日 2017-09-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice. Endocrinol Diabetes Metab, 1, 2018
7MJP	Vascular KATP channel: Kir6.1 SUR2B propeller-like conformation 2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Sung, M.W, Shyng, S.L. 登録日 2021-04-20 公開日 2021-10-13 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. Proc.Natl.Acad.Sci.USA, 118, 2021
5CAJ	Crystal structure of E. coli YaaA, a member of the DUF328/UPF0246 family 分子名称: BENZAMIDINE, CHLORIDE ION, UPF0246 protein YaaA 著者 Prahlad, J, Lin, J, Wilson, M.A. 登録日 2015-06-29 公開日 2016-02-24 最終更新日 2020-10-28 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 The DUF328 family member YaaA is a DNA-binding protein with a novel fold. J.Biol.Chem., 295, 2020
5G08	Crystal structure of Drosophila NCS-1 bound to chlorpromazine 分子名称: 1,2-ETHANEDIOL, 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, CALCIUM ION, ... 著者 Chaves-Sanjuan, A, Infantes, L, Sanchez-Barrena, M.J. 登録日 2016-03-17 公開日 2017-01-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1SOA	Human DJ-1 with sulfinic acid 分子名称: RNA-binding protein regulatory subunit; oncogene DJ1 著者 Canet-Aviles, R, Wilson, M.A, Miller, D.W, Ahmad, R, McLendon, C, Bandyopadhyay, S, Baptista, M.J, Ringe, D, Petsko, G.A, Cookson, M.R. 登録日 2004-03-13 公開日 2004-06-22 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc.Natl.Acad.Sci.USA, 101, 2004
5CCH	Structure of the Ca2+-bound synaptotagmin-1 SNARE complex (short unit cell form) 分子名称: CALCIUM ION, Synaptosomal-associated protein 25, Synaptotagmin-1, ... 著者 Zhou, Q, Zhao, M, Lyubimov, A.Y, Uervirojnangkoorn, M, Zeldin, O.B, Weis, W.I, Brunger, A.T. 登録日 2015-07-02 公開日 2015-08-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. Nature, 525, 2015
7MJQ	Vascular KATP channel: Kir6.1 SUR2B quatrefoil-like conformation 2 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 8, ... 著者 Sung, M.W, Shyng, S.L. 登録日 2021-04-20 公開日 2021-10-13 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Vascular K ATP channel structural dynamics reveal regulatory mechanism by Mg-nucleotides. Proc.Natl.Acad.Sci.USA, 118, 2021
5FKO	TetR(D) E147A mutant in complex with anhydrotetracycline and magnesium 分子名称: 5A,6-ANHYDROTETRACYCLINE, CHLORIDE ION, MAGNESIUM ION, ... 著者 Werten, S, Schneider, J, Palm, G.J, Hinrichs, W. 登録日 2015-10-17 公開日 2016-04-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Modular Organisation of Inducer Recognition and Allostery in the Tetracycline Repressor FEBS J., 283, 2016
5FJZ	Yeast delta-COP-I mu-homology domain complexed with Dsl1 WxWxV peptide 分子名称: COATOMER SUBUNIT DELTA, PROTEIN TRANSPORT PROTEIN DSL1 著者 Suckling, R.J, Evans, P.R, Owen, D.J. 登録日 2015-10-14 公開日 2015-11-11 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Basis for the Binding of Tryptophan-Based Motifs by Delta-Cop. Proc.Natl.Acad.Sci.USA, 112, 2015

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