7R02

Mus musculus acetylcholinesterase in complex with N-(3-(diethylamino)propyl)-4-methyl-3-nitrobenzamide

Summary for 7R02

• Entry DOI: 10.2210/pdb7r02/pdb
• Related: 7QYN 7R0A 7R2F 7R3C 7R4E
• Descriptor: Acetylcholinesterase, ~{N}-[(~{E})-3-(diethylamino)prop-2-enyl]-4-methyl-3-nitro-benzamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: hydrolase, complex, inhibitor
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 122722.61

Authors

Forsgren, N.,Lindgren, C.,Edvinsson, L.,Linusson, A.,Ekstrom, F. (deposition date: 2022-02-01, release date: 2022-04-27, Last modification date: 2024-01-31)

• Primary citation: Lindgren, C.,Forsgren, N.,Hoster, N.,Akfur, C.,Artursson, E.,Edvinsson, L.,Svensson, R.,Worek, F.,Ekstrom, F.,Linusson, A.; Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase.; Chemistry, 28:e202200678-e202200678, 2022; PubMed: 35420233; DOI: 10.1002/chem.202200678

Experimental method

X-RAY DIFFRACTION (2.3 Å)