7R2F

Structure of tabun inhibited acetylcholinesterase in complex with 2-((hydroxyimino)methyl)-1-(5-(4-methyl-3-nitrobenzamido)pentyl)pyridinium

Summary for 7R2F

Entry DOI	10.2210/pdb7r2f/pdb
Related	7QYN 7R02 7R0A 7R3C 7R4E
Descriptor	Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-methyl-3-nitro-~{N}-[(2~{E},4~{E})-5-[2-[(oxidanylamino)methyl]pyridin-1-yl]penta-2,4-dienyl]benzamide, ... (6 entities in total)
Functional Keywords	hydrolase, complex, tabun phosphylated, reactivator
Biological source	Mus musculus (house mouse)
Total number of polymer chains	2
Total formula weight	123050.94
Authors	Forsgren, N.,Lindgren, C.,Edvinsson, L.,Linusson, A.,Ekstrom, F. (deposition date: 2022-02-04, release date: 2022-04-27, Last modification date: 2024-01-31)
Primary citation	Lindgren, C.,Forsgren, N.,Hoster, N.,Akfur, C.,Artursson, E.,Edvinsson, L.,Svensson, R.,Worek, F.,Ekstrom, F.,Linusson, A. Broad-Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve-Agent-Inhibited Acetylcholinesterase. Chemistry, 28:e202200678-e202200678, 2022 Cited by PubMed: 35420233 DOI: 10.1002/chem.202200678 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation