5G08

Crystal structure of Drosophila NCS-1 bound to chlorpromazine

Summary for 5G08

Entry DOI	10.2210/pdb5g08/pdb
Related	5FYX
Descriptor	FREQUENIN 2, CALCIUM ION, 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, ... (6 entities in total)
Functional Keywords	signaling protein, calcium sensor
Biological source	DROSOPHILA MELANOGASTER (FRUIT FLY)
Total number of polymer chains	1
Total formula weight	22607.80
Authors	Chaves-Sanjuan, A.,Infantes, L.,Sanchez-Barrena, M.J. (deposition date: 2016-03-17, release date: 2017-01-25, Last modification date: 2024-01-31)
Primary citation	Mansilla, A.,Chaves-Sanjuan, A.,Campillo, N.E.,Semelidou, O.,Martinez-Gonzalez, L.,Infantes, L.,Gonzalez-Rubio, J.M.,Gil, C.,Conde, S.,Skoulakis, E.M.,Ferrus, A.,Martinez, A.,Sanchez-Barrena, M.J. Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome. Proc. Natl. Acad. Sci. U.S.A., 114:E999-E1008, 2017 Cited by PubMed: 28119500 DOI: 10.1073/pnas.1611089114 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.52 Å)

Structure validation