5G08

Crystal structure of Drosophila NCS-1 bound to chlorpromazine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0007268	biological_process	chemical synaptic transmission
A	0007269	biological_process	neurotransmitter secretion
A	0007528	biological_process	neuromuscular junction development
A	0008021	cellular_component	synaptic vesicle
A	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
A	0009966	biological_process	regulation of signal transduction
A	0016192	biological_process	vesicle-mediated transport
A	0046872	molecular_function	metal ion binding
A	0046928	biological_process	regulation of neurotransmitter secretion

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1184

Chain	Residue
A	ASP73
A	ASN75
A	ASP77
A	ALA79
A	GLU84
A	HOH2090

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1185

Chain	Residue
A	ARG162
A	GLU167
A	HOH2139
A	ASP156
A	ASN158
A	ASP160

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1186

Chain	Residue
A	ASP109
A	ASP111
A	ASP113
A	TYR115
A	GLU120
A	HOH2114

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE Z80 A 1187

Chain	Residue
A	TYR52
A	PHE72
A	PHE85
A	THR92
A	GOL1188
A	EDO1190
A	HOH2045

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 1188

Chain	Residue
A	TRP30
A	PHE85
A	Z801187
A	EDO1190

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1189

Chain	Residue
A	THR18
A	ASP19
A	THR20
A	HOH2160
A	HOH2161

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1190

Chain	Residue
A	ASP37
A	ILE51
A	Z801187
A	GOL1188
A	HOH2164

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DENNDGAIEfeEF

Chain	Residue	Details
A	ASP73-PHE85
A	ASP109-MET121
A	ASP156-PHE168

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	35
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	35
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	35
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25074811","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28119500","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29966094","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BY4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4BY5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5G08","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EPA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---