PDB: 23765 件ウェブページステータス検索Chemie searchBIRD

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6VUS	Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT379 分子名称: 2-[(4-amino-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-[2-(diethylamino)ethyl]acetamide, GLYCEROL, N-acetyltransferase Eis 著者 Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2020-02-16 公開日 2020-06-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
6VV2	Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT1348 分子名称: 2-{[3-(piperidin-1-yl)propyl]sulfanyl}-6,7,8,9-tetrahydro-5H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-amine, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2020-02-16 公開日 2020-06-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
6VUX	Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT388 分子名称: 2-{[(7S)-4-amino-7-ethyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-2-yl]sulfanyl}-N-[2-(piperidin-1-yl)ethyl]acetamide, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2020-02-16 公開日 2020-06-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
6VUY	Crystal structure of Eis from Mycobacterium tuberculosis in complex with inhibitor SGT358 分子名称: (7S)-7-phenyl-2-{[3-(piperidin-1-yl)propyl]sulfanyl}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-amine, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... 著者 Punetha, A, Hou, C, Ngo, H.X, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2020-02-16 公開日 2020-06-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis fromMycobacterium tuberculosis. Acs Chem.Biol., 15, 2020
9MQZ	Structure of mycobacterial NDH2 (type II NADH:quinone oxidoreductase) with 2-mercapto-quinazolinone inhibitor. 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, N-cyclohexyl-2-[(4-oxo-1,4-dihydroquinazolin-2-yl)sulfanyl]acetamide, NADH:ubiquinone reductase (non-electrogenic) 著者 Liang, Y, Rubinstein, J.L. 登録日 2025-01-06 公開日 2025-01-22 最終更新日 2025-05-28 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure of Mycobacterial NDH-2 Bound to a 2-Mercapto-Quinazolinone Inhibitor. J.Med.Chem., 68, 2025
9MQY	Structure of mycobacterial NDH2 (type II NADH:quinone oxidoreductase) 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, NADH:ubiquinone reductase (non-electrogenic) 著者 Liang, Y, Rubinstein, J.L. 登録日 2025-01-06 公開日 2025-01-22 最終更新日 2025-05-21 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure of Mycobacterial NDH-2 Bound to a 2-Mercapto-Quinazolinone Inhibitor. J.Med.Chem., 68, 2025
6PLE	Crystal structure of MhuD R26S mutant in complex with biliverdin 分子名称: BILIVERDINE IX ALPHA, Heme oxygenase (mycobilin-producing) 著者 Chao, A, Goulding, C.W. 登録日 2019-06-30 公開日 2019-11-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of aMycobacterium tuberculosisHeme-Degrading Protein, MhuD, Variant in Complex with Its Product. Biochemistry, 58, 2019
6H40	High resolution structure of MeT1 from Mycobacterium hassiacum in complex with 3-methoxy-1,2-propanediol. 分子名称: (2~{S})-3-methoxypropane-1,2-diol, CHLORIDE ION, GLYCEROL, ... 著者 Pereira, P.J.B, Ripoll-Rozada, J. 登録日 2018-07-20 公開日 2019-01-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.053 Å) 主引用文献 Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
8HPM	LpqY-SugABC in state 2 分子名称: ABC sugar transporter, permease component, ABC transporter, ... 著者 Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. 登録日 2022-12-12 公開日 2023-09-06 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (3.82 Å) 主引用文献 Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
8HPN	LpqY-SugABC in state 3 分子名称: ABC sugar transporter, permease component, ABC transporter, ... 著者 Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. 登録日 2022-12-12 公開日 2023-09-06 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (4.55 Å) 主引用文献 Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
8HPS	LpqY-SugABC in state 5 分子名称: ABC sugar transporter, permease component, ABC transporter, ... 著者 Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. 登録日 2022-12-12 公開日 2023-09-06 最終更新日 2025-06-18 実験手法 ELECTRON MICROSCOPY (3.51 Å) 主引用文献 Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
8HPL	LpqY-SugABC in state 1 分子名称: ABC sugar transporter, permease component, ABC transporter, ... 著者 Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. 登録日 2022-12-12 公開日 2023-09-06 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (4.29 Å) 主引用文献 Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
8HPR	LpqY-SugABC in state 4 分子名称: ABC sugar transporter, permease component, ABC transporter, ... 著者 Liang, J, Yang, X, Zhang, B, Rao, Z, Liu, F. 登録日 2022-12-12 公開日 2023-09-06 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (3.75 Å) 主引用文献 Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC. Structure, 31, 2023
5UHB	Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with Rifampin 分子名称: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2017-01-11 公開日 2017-04-12 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (4.29 Å) 主引用文献 Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
5UHF	Crystal structure of Mycobacterium tuberculosis transcription initiation complex in complex with D-IX336 分子名称: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2017-01-11 公開日 2017-04-12 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (4.345 Å) 主引用文献 Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
5UHA	Crystal structure of Mycobacterium tuberculosis transcription initiation complex 分子名称: DNA (5'-D(*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Lin, W, Das, K, Feng, Y, Ebright, R.H. 登録日 2017-01-11 公開日 2017-04-12 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.906 Å) 主引用文献 Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Mol. Cell, 66, 2017
9MVA	Mycobacterium abscessus Eis2 in complex with Non-hydrolyzable CoenzymeA 分子名称: 1,2-ETHANEDIOL, Amikacin resistance N-acetyltransferase Eis2, CHLORIDE ION, ... 著者 Jayasinghe, T.D, Coker, A.L, Rajendra, T, Miller, D, Lee, R.E. 登録日 2025-01-15 公開日 2025-01-29 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Mycobacterium abscessus Eis2 in complex with Non-hydrolyzable CoenzymeA To Be Published
5BQA	Structure of the yeast F1FO ATPase C10 ring with oligomycin C 分子名称: ATP synthase subunit 9, mitochondrial, oligomycin C 著者 Symersky, J, Xu, T, Mueller, D.M. 登録日 2015-05-28 公開日 2015-08-26 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the yeast F1FO ATPase C10 ring with oligomycin C To be Published
5BQ6	Structure of the yeast F1FO ATPase C10 ring with oligomycin B 分子名称: ATP synthase subunit 9, mitochondrial, oligomycin B 著者 Symersky, J, Xu, T, Mueller, D.M. 登録日 2015-05-28 公開日 2015-08-26 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the yeast F1FO ATPase C10 ring with oligomycin B To be Published
5BPS	Structure of the yeast F1FO ATPase C10 ring with oligomycin A 分子名称: ATP synthase subunit 9, mitochondrial, Oligomycin A 著者 Symersky, J, Xu, T, Mueller, D.M. 登録日 2015-05-28 公開日 2015-08-26 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of the yeast F1FO ATPase C10 ring with oligomycin A To be Published
3WDE	Mutant N-terminal domain of Mycobacterium tuberculosis ClpC1, F80Y, bound to Cyclomarin A 分子名称: ACETATE ION, Cyclomarin A, Probable ATP-dependent Clp protease ATP-binding subunit 著者 Vasudevan, D, Noble, C.G. 登録日 2013-06-14 公開日 2013-09-18 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 Structural basis of mycobacterial inhibition by cyclomarin A J.Biol.Chem., 288, 2013
3WDD	Mutant N-terminal domain of Mycobacterium tuberculosis ClpC1, F2Y, bound to Cyclomarin A 分子名称: ACETATE ION, Cyclomarin A, Probable ATP-dependent Clp protease ATP-binding subunit 著者 Vasudevan, D, Noble, C.G. 登録日 2013-06-14 公開日 2013-09-18 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Structural basis of mycobacterial inhibition by cyclomarin A J.Biol.Chem., 288, 2013
3WDC	N-terminal domain of Mycobacterium tuberculosis ClpC1 bound to Cyclomarin A 分子名称: ACETATE ION, Cyclomarin A, Probable ATP-dependent Clp protease ATP-binding subunit 著者 Vasudevan, D, Noble, C.G. 登録日 2013-06-14 公開日 2013-09-18 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.18 Å) 主引用文献 Structural basis of mycobacterial inhibition by cyclomarin A J.Biol.Chem., 288, 2013
7Y41	Mycobacterium smegmatis 50S ribosomal subunit from Log Phase of growth 分子名称: 23S ribosomal RNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... 著者 Sengupta, J, Baid, P. 登録日 2022-06-13 公開日 2023-05-03 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Cryo-EM captures a unique conformational rearrangement in 23S rRNA helices of the Mycobacterium 50S subunit. Int.J.Biol.Macromol., 253, 2023
4W1X	Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with 1-(4-(4-(3-chlorobenzoyl)piperazin-1-yl)phenyl)ethanone 分子名称: 1,2-ETHANEDIOL, 1-{4-[4-(3-chlorobenzoyl)piperazin-1-yl]phenyl}ethanone, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, ... 著者 Finzel, B.C, Dai, R. 登録日 2014-08-13 公開日 2015-02-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis. Chem.Biol., 22, 2015

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