2C6K
| Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor | 分子名称: | 4-{[5-(CYCLOHEXYLAMINO)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE, CELL DIVISION PROTEIN KINASE 2 | 著者 | Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. | 登録日 | 2005-11-10 | 公開日 | 2005-12-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Triazolo[1,5-A]Pyrimidines as Novel Cdk2 Inhibitors: Protein Structure-Guided Design and Sar. Bioorg.Med.Chem.Lett., 16, 2006
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2BKR
| NEDD8 NEDP1 complex | 分子名称: | NEDDYLIN, SENTRIN-SPECIFIC PROTEASE 8 | 著者 | Shen, L.N, Liu, H, Dong, C, Xirodimas, D, Naismith, J.H, Hay, R.T. | 登録日 | 2005-02-18 | 公開日 | 2005-09-15 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Basis of Nedd8 Ubiquitin Discrimination by the Deneddylating Enzyme Nedp1 Embo J., 24, 2005
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7M2E
| Crystal structure of BPTF bromodomain in complex with CB02-092 | 分子名称: | 4-chloro-5-{4-[2-(dimethylamino)ethyl]anilino}-2-methylpyridazin-3(2H)-one, Nucleosome-remodeling factor subunit BPTF | 著者 | Nithianantham, S, Fischer, M. | 登録日 | 2021-03-16 | 公開日 | 2022-02-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition J.Med.Chem., 64, 2021
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1IB1
| CRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX | 分子名称: | 14-3-3 ZETA ISOFORM, COA-S-ACETYL TRYPTAMINE, SEROTONIN N-ACETYLTRANSFERASE | 著者 | Obsil, T, Ghirlando, R, Klein, D.C, Ganguly, S, Dyda, F. | 登録日 | 2001-03-26 | 公開日 | 2001-05-02 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Cell(Cambridge,Mass.), 105, 2001
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5J9Q
| Crystal structure of the NuA4 core complex | 分子名称: | Chromatin modification-related protein EAF6, Chromatin modification-related protein YNG2, Enhancer of polycomb-like protein 1, ... | 著者 | Chen, Z.C, Xu, P. | 登録日 | 2016-04-11 | 公開日 | 2016-10-26 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | The NuA4 Core Complex Acetylates Nucleosomal Histone H4 through a Double Recognition Mechanism Mol.Cell, 63, 2016
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7N16
| Structure of TAX-4_R421W apo closed state | 分子名称: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, SODIUM ION | 著者 | Zheng, X, Li, H, Hu, Z, Su, D, Yang, J. | 登録日 | 2021-05-27 | 公開日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and functional characterization of an achromatopsia-associated mutation in a phototransduction channel. Commun Biol, 5, 2022
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7N17
| Structure of TAX-4_R421W apo open state | 分子名称: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel | 著者 | Zheng, X, Li, H, Hu, Z, Su, D, Yang, J. | 登録日 | 2021-05-27 | 公開日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural and functional characterization of an achromatopsia-associated mutation in a phototransduction channel. Commun Biol, 5, 2022
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7N15
| Structure of TAX-4_R421W w/cGMP open state | 分子名称: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLIC GUANOSINE MONOPHOSPHATE, ... | 著者 | Zheng, X, Li, H, Hu, Z, Su, D, Yang, J. | 登録日 | 2021-05-27 | 公開日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural and functional characterization of an achromatopsia-associated mutation in a phototransduction channel. Commun Biol, 5, 2022
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7ZSD
| cryo-EM structure of omicron spike in complex with de novo designed binder, local | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, de novo designed binder | 著者 | Pablo, G, Sarah, W, Alexandra, V.H, Anthony, M, Andreas, S, Zander, H, Dongchun, N, Shuguang, T, Freyr, S, Casper, G, Priscilla, T, Alexandra, T, Stephane, R, Sandrine, G, Jane, M, Aaron, P, Zepeng, X, Yan, C, Pu, H, George, G, Elisa, O, Beat, F, Didier, T, Henning, S, Michael, B, Bruno, E.C. | 登録日 | 2022-05-06 | 公開日 | 2023-03-01 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | De novo design of protein interactions with learned surface fingerprints. Nature, 617, 2023
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7ZSS
| cryo-EM structure of D614 spike in complex with de novo designed binder | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Pablo, G, Sarah, W, Alexandra, V.H, Anthony, M, Andreas, S, Zander, H, Dongchun, N, Shuguang, T, Freyr, S, Casper, G, Priscilla, T, Alexandra, T, Stephane, R, Sandrine, G, Jane, M, Aaron, P, Zepeng, X, Yan, C, Pu, H, George, G, Elisa, O, Beat, F, Didier, T, Henning, S, Michael, B, Bruno, E.C. | 登録日 | 2022-05-08 | 公開日 | 2023-03-01 | 最終更新日 | 2023-05-24 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | De novo design of protein interactions with learned surface fingerprints. Nature, 617, 2023
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2C5V
| Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design | 分子名称: | 4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE, ALA-ALA-ABA-ARG-SER-LEU-ILE-PFF-NH2, CELL DIVISION PROTEIN KINASE 2, ... | 著者 | Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. | 登録日 | 2005-11-02 | 公開日 | 2006-03-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
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2C5N
| Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design | 分子名称: | CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE | 著者 | Kontopidis, G, McInnes, C, Pandalaneni, S.R, McNae, I, Gibson, D, Mezna, M, Thomas, M, Wood, G, Wang, S, Walkinshaw, M.D, Fischer, P.M. | 登録日 | 2005-10-30 | 公開日 | 2006-03-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Differential Binding of Inhibitors to Active and Inactive Cdk2 Provides Insights for Drug Design. Chem.Biol., 13, 2006
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2C69
| Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor | 分子名称: | (5Z)-5-(3-BROMOCYCLOHEXA-2,5-DIEN-1-YLIDENE)-N-(PYRIDIN-4-YLMETHYL)-1,5-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE, CELL DIVISION PROTEIN KINASE 2 | 著者 | Richardson, C.M, Dokurno, P, Murray, J.B, Surgenor, A.E. | 登録日 | 2005-11-08 | 公開日 | 2005-12-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR. Bioorg. Med. Chem. Lett., 16, 2006
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2BEC
| Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation | 分子名称: | Calcineurin B homologous protein 2, Sodium/hydrogen exchanger 1, YTTRIUM (III) ION | 著者 | Ben Ammar, Y, Takeda, S, Hisamitsu, T, Mori, H, Wakabayashi, S. | 登録日 | 2005-10-24 | 公開日 | 2006-06-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation Embo J., 25, 2006
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2BTR
| STRUCTURE OF CDK2 COMPLEXED WITH PNU-198873 | 分子名称: | CELL DIVISION PROTEIN KINASE 2, N-(5-ISOPROPYL-THIAZOL-2-YL)-2-PYRIDIN-3-YL-ACETAMIDE | 著者 | Vulpetti, A, Casale, E, Roletto, F, Amici, R, Villa, M, Pevarello, P. | 登録日 | 2005-06-06 | 公開日 | 2005-11-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure-Based Drug Design to the Discovery of New 2-Aminothiazole Cdk2 Inhibitors. J.Mol.Graph.Model., 24, 2006
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3JVJ
| Crystal structure of the bromodomain 1 in mouse Brd4 | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GLYCEROL | 著者 | Vollmuth, F, Blankenfeldt, W, Geyer, M. | 登録日 | 2009-09-17 | 公開日 | 2009-10-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution J.Biol.Chem., 284, 2009
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4NM3
| Crystal structure of GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ADENOSINE-5'-DIPHOSPHATE, Axin-1, ... | 著者 | Chu, M.L.-H, Stamos, J.L, Enos, M.D, Shah, N, Weis, W.I. | 登録日 | 2013-11-14 | 公開日 | 2014-03-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife, 3, 2014
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5ILU
| Autoinhibited ETV4 | 分子名称: | ETS translocation variant 4 | 著者 | Whitby, F.G, Currie, S.L. | 登録日 | 2016-03-04 | 公開日 | 2017-02-22 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (1.101 Å) | 主引用文献 | Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5. Nucleic Acids Res., 45, 2017
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8BWJ
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1ZZ0
| Crystal structure of a HDAC-like protein with acetate bound | 分子名称: | ACETATE ION, Histone deacetylase-like amidohydrolase, POTASSIUM ION, ... | 著者 | Nielsen, T.K, Hildmann, C, Dickmanns, A, Schwienhorst, A, Ficner, R. | 登録日 | 2005-06-13 | 公開日 | 2005-11-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of a bacterial class 2 histone deacetylase homologue J.Mol.Biol., 354, 2005
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8BWX
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3FVJ
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4NM0
| Crystal structure of peptide inhibitor-free GSK-3/Axin complex | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ADENOSINE-5'-DIPHOSPHATE, Axin-1, ... | 著者 | Chu, M.L.-H, Stamos, J.L, Enos, M.D, Shah, N, Weis, W.I. | 登録日 | 2013-11-14 | 公開日 | 2014-03-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6. Elife, 3, 2014
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4NZL
| Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases | 分子名称: | Neutrophil elastase, Uncharacterized protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Stapels, D.A.C, von Koeckritz-Blickwede, M, Ramyar, K.X, Bischoff, M, Milder, F, Ruyken, M, Scheepmaker, L, McWhorter, W.J, Herrmann, M, van Kessel, K.P.M, Geisbrecht, B.V, Rooijakkers, S.H.M. | 登録日 | 2013-12-12 | 公開日 | 2014-08-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors. Proc.Natl.Acad.Sci.USA, 111, 2014
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4O10
| Structural and Biochemical Analyses of the Catalysis and Potency Impact of Inhibitor Phosphoribosylation by Human Nicotinamide Phosphoribosyltransferase | 分子名称: | 1,2-ETHANEDIOL, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}indolizine-7-carboxamide, Nicotinamide phosphoribosyltransferase, ... | 著者 | Oh, A, Wang, W. | 登録日 | 2013-12-14 | 公開日 | 2014-06-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Chembiochem, 15, 2014
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