4NM3

Crystal structure of GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide

Summary for 4NM3

• Entry DOI: 10.2210/pdb4nm3/pdb
• Related: 4NM0 4NM5 4NM7 4NU1
• Descriptor: Glycogen synthase kinase-3 beta, Axin-1, GLYCEROL, ... (8 entities in total)
• Functional Keywords: wnt, lrp6, auto-inhibited, gsk-3, axin, kinase, primed substrate, phosphorylated n-terminal auto-inhibitory ps9 peptide, transferase-peptide complex, transferase/peptide
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P49841 O15169
• Total number of polymer chains: 2
• Total formula weight: 48032.64

Authors

Chu, M.L.-H.,Stamos, J.L.,Enos, M.D.,Shah, N.,Weis, W.I. (deposition date: 2013-11-14, release date: 2014-03-26, Last modification date: 2023-09-20)

• Primary citation: Stamos, J.L.,Chu, M.L.,Enos, M.D.,Shah, N.,Weis, W.I.; Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6.; Elife, 3:e01998-e01998, 2014; PubMed: 24642411

Experimental method

X-RAY DIFFRACTION (2.1 Å)