8BWX

Fragment-linked stabilizer for 14-3-3 and ERa (1075298)

Summary for 8BWX

• Entry DOI: 10.2210/pdb8bwx/pdb
• Descriptor: 14-3-3 protein sigma, ERalpha peptide, 4-azanyl-~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]-1-(4-chloranylphenoxy)cyclohexane-1-carboxamide, ... (4 entities in total)
• Functional Keywords: 14-3-3, era, stabilization, fragment linking, structural protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 27641.51

Authors

Visser, E.J.,Vandenboorn, E.M.F.,Ottmann, C. (deposition date: 2022-12-07, release date: 2023-08-02, Last modification date: 2023-11-15)

• Primary citation: Visser, E.J.,Jaishankar, P.,Sijbesma, E.,Pennings, M.A.M.,Vandenboorn, E.M.F.,Guillory, X.,Neitz, R.J.,Morrow, J.,Dutta, S.,Renslo, A.R.,Brunsveld, L.,Arkin, M.R.,Ottmann, C.; From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking.; Angew.Chem.Int.Ed.Engl., 62:e202308004-e202308004, 2023; PubMed: 37455289; DOI: 10.1002/anie.202308004

Experimental method

X-RAY DIFFRACTION (1.6 Å)