PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

---

6YE9	Small-molecule inhibitor of 14-3-3 protein-protein interactions 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, [2-[2-oxidanylidene-2-[(phenylmethyl)amino]ethoxy]phenyl]phosphonic acid 著者 Ottmann, C, Visser, E.J. 登録日 2020-03-24 公開日 2021-03-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based conversion of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions To Be Published
7ZW7	Crystal structure of Schistosoma mansoni HDAC8 in complex with a formate molecule in the active site 分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... 著者 Saccoccia, F, Giannaccari, M, Ruberti, G. 登録日 2022-05-19 公開日 2023-05-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystal structure of Schistosoma mansoni HDAC8 in complex with a formate molecule in the active site To Be Published
6Y7T	Engineered conjugation of lysine-specific molecular tweezers with ExoS derived peptidic inhibitor enhance affinity towards target protein 14-3-3 through ditopic binding 分子名称: 14-3-3 protein sigma, ExoSTWZ molecular tweezer, Exoenzyme S, ... 著者 Guillory, X, Ottmann, C. 登録日 2020-03-02 公開日 2021-03-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Supramolecular Enhancement of a Natural 14-3-3 Protein Ligand. J.Am.Chem.Soc., 143, 2021
4AWL	The NF-Y transcription factor is structurally and functionally a sequence specific histone 分子名称: HSP70 PROMOTER FRAGMENT, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT ALPHA, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA, ... 著者 Nardini, M, Gnesutta, N, Donati, G, Gatta, R, Forni, C, Fossati, A, Vonrhein, C, Moras, D, Romier, C, Mantovani, R, Bolognesi, M. 登録日 2012-06-04 公開日 2013-01-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Sequence-Specific Transcription Factor NF-Y Displays Histone-Like DNA Binding and H2B-Like Ubiquitination. Cell(Cambridge,Mass.), 152, 2013
6YIC	14-3-3 sigma in complex with SMAD4 pS403 peptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, GLYCEROL, ... 著者 Kiehstaller, S, Graf, S, Hennig, S. 登録日 2020-04-01 公開日 2021-04-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Identification and characterization of 14-3-3/SMAD protein-protein-interactions To Be Published
6YIA	14-3-3 sigma in complex with SMAD2 pS465 peptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Kiehstaller, S, Graf, S, Hennig, S. 登録日 2020-04-01 公開日 2021-04-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Identification and characterization of 14-3-3/SMAD protein-protein-interactions To Be Published
6YIB	14-3-3 sigma in complex with SMAD3 pS423 peptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Kiehstaller, S, Graf, S, Hennig, S. 登録日 2020-04-01 公開日 2021-04-14 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Identification and characterization of 14-3-3/SMAD protein-protein-interactions To Be Published
6YR7	14-3-3 sigma in complex with hDMX-342+367 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Protein Mdm4 著者 Wolter, M, Srdanovic, S, Warriner, S, Wilson, A, Ottmann, C. 登録日 2020-04-19 公開日 2021-11-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.105 Å) 主引用文献 Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
6YR6	14-3-3 sigma in complex with hDM2-186 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IODIDE ION, ... 著者 Wolter, M, Srdanovic, S, Warriner, S, Wilson, A, Ottmann, C. 登録日 2020-04-19 公開日 2021-11-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
6YR5	14-3-3 sigma in complex with hDMX-367 peptide 分子名称: 14-3-3 protein sigma, Protein Mdm4, SULFATE ION 著者 Wolter, M, Srdanovic, S, Ottman, C, Warriner, S, Wilson, A. 登録日 2020-04-19 公開日 2021-11-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Understanding the interaction of 14-3-3 proteins with hDMX and hDM2: a structural and biophysical study. Febs J., 2022
7ZLW	NME1 in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Nucleoside diphosphate kinase A 著者 Garcia-Saez, I, Iuso, D, Khochbin, S, Petosa, C. 登録日 2022-04-15 公開日 2023-08-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet. Sci Adv, 9, 2023
7ZL8	NME1 in complex with succinyl-CoA 分子名称: Nucleoside diphosphate kinase A, SUCCINYL-COENZYME A 著者 Garcia-Saez, I, Iuso, D, Khochbin, S, Petosa, C. 登録日 2022-04-14 公開日 2023-08-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet. Sci Adv, 9, 2023
7ZTK	NME1 in complex with CoA 分子名称: COENZYME A, Nucleoside diphosphate kinase A 著者 Garcia-Saez, I, Iuso, D, Khochbin, S, Petosa, C. 登録日 2022-05-10 公開日 2023-08-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Nucleoside diphosphate kinases 1 and 2 regulate a protective liver response to a high-fat diet. Sci Adv, 9, 2023
7ZHF	GPN-loop GTPase from Sulfolobus acidocaldarius closed state (GppNHp) 分子名称: CHLORIDE ION, GLYCEROL, GTPase, ... 著者 Korf, L, Essen, L.-O. 登録日 2022-04-06 公開日 2023-10-25 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis. Mbio, 14, 2023
7ZHK	GPN-loop GTPase from Sulfolobus acidocaldarius open state (GDP) 分子名称: GTPase, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Korf, L, Essen, L.-O. 登録日 2022-04-06 公開日 2023-10-25 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis. Mbio, 14, 2023
4G7L	Crystal Structure of rat Heme oxygenase-1 in complex with Heme and O2 分子名称: FORMIC ACID, Heme oxygenase 1, OXYGEN MOLECULE, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-20 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
5VQF	Crystal Structure of pro-TGF-beta 1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Zhao, B, Xu, S, Dong, X, Lu, C, Springer, T.A. 登録日 2017-05-08 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Prodomain-growth factor swapping in the structure of pro-TGF-beta 1. J. Biol. Chem., 293, 2018
4GCJ	CDK2 in complex with inhibitor RC-3-89 分子名称: 1,2-ETHANEDIOL, 4-{[4-amino-5-(2-nitrobenzoyl)-1,3-thiazol-2-yl]amino}benzenesulfonamide, Cyclin-dependent kinase 2 著者 Betzi, S, Alam, R, Han, H, Becker, A, Schonbrunn, E. 登録日 2012-07-30 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases. J.Med.Chem., 56, 2013
4G99	Rat Heme Oxygenase-1 in complex with Heme and CO at 100 K after warming to 160 K 分子名称: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-23 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
8AG2	Crystal structure of the BPTF bromodomain in complex with BI-7190 分子名称: 5-[3-methoxy-4-[1-(4-methylpiperazin-1-yl)cyclopropyl]phenyl]-1,3,4-trimethyl-pyridin-2-one, Nucleosome-remodeling factor subunit BPTF 著者 Bader, G, Boettcher, J, Wolkerstorfer, B. 登録日 2022-07-19 公開日 2022-08-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.025 Å) 主引用文献 Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments. Chemmedchem, 18, 2023
7M2F	CDK2 with compound 14 inhibitor with carboxylate 分子名称: Cyclin-dependent kinase 2, [(1r,4r)-4-{4-[4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl}cyclohexyl]acetic acid 著者 Longenecker, K.L, Qiu, W, Korepanova, A, Tong, Y. 登録日 2021-03-16 公開日 2021-07-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.632 Å) 主引用文献 Balancing Properties with Carboxylates: A Lead Optimization Campaign for Selective and Orally Active CDK9 Inhibitors. Acs Med.Chem.Lett., 12, 2021
4FX3	Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor 分子名称: (3Z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1H-indole-5-carboxylic acid, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Cyclin-A2, ... 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-07-02 公開日 2013-05-15 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor To be Published
6ZCJ	14-3-3sigma in complex with SLP76pS376 phosphopeptide crystal structure 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, SLP76pS376 著者 Soini, L, Leysen, S, Davis, J, Ottmann, C. 登録日 2020-06-11 公開日 2020-12-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization. Febs Lett., 595, 2021
4G8W	Rat Heme Oxygenase-1 in complex with Heme and O2 with 13 hr illumination: Laser on 分子名称: FORMIC ACID, Heme oxygenase 1, OXYGEN MOLECULE, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-23 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
8AG0	Crystal structure of mutant PRELID3a-TRIAP1 complex - R53E 分子名称: Maltose/maltodextrin-binding periplasmic protein,TP53-regulated inhibitor of apoptosis 1, PRELI domain containing protein 3A, alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose 著者 Milara, X, Perez-Dorado, J.I, Matthews, S.J. 登録日 2022-07-18 公開日 2022-11-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 An intermolecular hydrogen bonded network in the PRELID-TRIAP protein family plays a role in lipid sensing. Biochim Biophys Acta Proteins Proteom, 1871, 2022

<300301302303304305306307308309310311312313314315>