4FX3

Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor

Summary for 4FX3

Related4EK3 4EK4 4EK5 4EK6 4EK8 4FKG 4FKI 4FKJ 4FKL 4FKO 4FKP 4FKQ 4FKR 4FKS 4FKT 4FKU 4FKV 4FKW
DescriptorCyclin-dependent kinase 2, Cyclin-A2, (3Z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1H-indole-5-carboxylic acid, ... (5 entities in total)
Functional Keywordscomplex (transferase-cyclin), transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Nucleus  P20248
Total number of polymer chains4
Total molecular weight128385.01
Authors
Kang, Y.N.,Stuckey, J.A. (deposition date: 2012-07-02, release date: 2013-05-15, Last modification date: 2017-11-15)
Primary citation
Kang, Y.N.,Stuckey, J.A.
Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor
To be Published,
Experimental method
X-RAY DIFFRACTION (2.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24420.3%0.8%3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report