4FX3
Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Cyclin-dependent kinase 2 | polymer | 298 | 33976.5 | 2 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | Cell division protein kinase 2, p33 protein kinase |
| 2 | B, D (B, D) | Cyclin-A2 | polymer | 258 | 29624.3 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (human) | Cyclin-A |
| 3 | E, H (A, C) | (3Z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1H-indole-5-carboxylic acid | non-polymer | 360.3 | 2 | Chemie (60K) | |||
| 4 | F, G, I (A, B, D) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 3 | Chemie (DTT) | |||
| 5 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 127201.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1183.4 | |
| All* | Total formula weight | 128385.0 |
