6YE9
Small-molecule inhibitor of 14-3-3 protein-protein interactions
Summary for 6YE9
Entry DOI | 10.2210/pdb6ye9/pdb |
Descriptor | 14-3-3 protein sigma, MAGNESIUM ION, [2-[2-oxidanylidene-2-[(phenylmethyl)amino]ethoxy]phenyl]phosphonic acid, ... (4 entities in total) |
Functional Keywords | 14-3-3, inhibitor, protein-protein interaction, small molecule, structural protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 26937.09 |
Authors | Ottmann, C.,Visser, E.J. (deposition date: 2020-03-24, release date: 2021-03-31, Last modification date: 2024-01-24) |
Primary citation | Sijbesma, E.,Visser, E.J.,Plitzko, K.,Thiel, P.,Milroy, L.G.,Kaiser, M.,Brunsveld, L.,Ottmann, C. Structure-based conversion of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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