1T69
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t69 by Molmil](/molmil-images/mine/1t69) | Crystal Structure of human HDAC8 complexed with SAHA | 分子名称: | Histone deacetylase 8, OCTANEDIOIC ACID HYDROXYAMIDE PHENYLAMIDE, ZINC ION | 著者 | Somoza, J.R, Skene, R.J, Katz, B.A, Mol, C, Ho, J.D, Jennings, A.J, Luong, C, Arvai, A, Buggy, J.J, Chi, E, Tang, J, Sang, B.-C, Verner, E, Wynands, R, Leahy, E.M, Dougan, D.R, Snell, G, Navre, M, Knuth, M.W, Swanson, R.V, McRee, D.E, Tari, L.W. | 登録日 | 2004-05-05 | 公開日 | 2004-07-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases Structure, 12, 2004
|
|
1SVP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1svp by Molmil](/molmil-images/mine/1svp) | SINDBIS VIRUS CAPSID PROTEIN | 分子名称: | SINDBIS VIRUS CAPSID PROTEIN | 著者 | Lee, S, Rossmann, M.G. | 登録日 | 1996-03-22 | 公開日 | 1996-08-17 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification of a protein binding site on the surface of the alphavirus nucleocapsid and its implication in virus assembly. Structure, 4, 1996
|
|
1T67
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t67 by Molmil](/molmil-images/mine/1t67) | Crystal Structure of Human HDAC8 complexed with MS-344 | 分子名称: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Histone deacetylase 8, SODIUM ION, ... | 著者 | Somoza, J.R, Skene, R.J, Katz, B.A, Mol, C, Ho, J.D, Jennings, A.J, Luong, C, Arvai, A, Buggy, J.J, Chi, E, Tang, J, Sang, B.-C, Verner, E, Wynands, R, Leahy, E.M, Dougan, D.R, Snell, G, Navre, M, Knuth, M.W, Swanson, R.V, McRee, D.E, Tari, L.W. | 登録日 | 2004-05-05 | 公開日 | 2004-07-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases Structure, 12, 2004
|
|
4II5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ii5 by Molmil](/molmil-images/mine/4ii5) | Structure of PCDK2/CYCLINA bound to ADP and 1 MAGNESIUM ION | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ... | 著者 | Jacobsen, D.M, Bao, Z.-Q, O'Brien, P.J, Brooks III, C.L, Young, M.A. | 登録日 | 2012-12-19 | 公開日 | 2013-01-23 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Price to be paid for two-metal catalysis: Magnesium ions that accelerate chemistry unavoidably limit product release from a PROTEIN KINASE J.Am.Chem.Soc., 134, 2012
|
|
4IEA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4iea by Molmil](/molmil-images/mine/4iea) | |
1T64
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t64 by Molmil](/molmil-images/mine/1t64) | Crystal Structure of human HDAC8 complexed with Trichostatin A | 分子名称: | CALCIUM ION, Histone deacetylase 8, SODIUM ION, ... | 著者 | Somoza, J.R, Skene, R.J, Katz, B.A, Mol, C, Ho, J.D, Jennings, A.J, Luong, C, Arvai, A, Buggy, J.J, Chi, E, Tang, J, Sang, B.-C, Verner, E, Wynands, R, Leahy, E.M, Dougan, D.R, Snell, G, Navre, M, Knuth, M.W, Swanson, R.V, McRee, D.E, Tari, L.W. | 登録日 | 2004-05-05 | 公開日 | 2004-07-27 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases Structure, 12, 2004
|
|
4IM3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4im3 by Molmil](/molmil-images/mine/4im3) | Structure of Tank-Binding Kinase 1 | 分子名称: | CHLORIDE ION, MERCURY (II) ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, ... | 著者 | Tu, D, Eck, M.J. | 登録日 | 2013-01-01 | 公開日 | 2013-03-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.342 Å) | 主引用文献 | Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep, 3, 2013
|
|
1T6R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1t6r by Molmil](/molmil-images/mine/1t6r) | Solution structure of TM1442, a putative anti sigma factor antagonist in phosphorylated state | 分子名称: | Putative anti-sigma factor antagonist TM1442 | 著者 | Etezady-Esfarjani, T, Placzek, W, Herrmann, T, Lesley, S.A, Wuthrich, K, Joint Center for Structural Genomics (JCSG) | 登録日 | 2004-05-07 | 公開日 | 2005-05-24 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structures of the putative anti-sigma-factor antagonist TM1442 from Thermotoga maritima in the free and phosphorylated states. Magn.Reson.Chem., 44 Spec No, 2006
|
|
4IQ6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4iq6 by Molmil](/molmil-images/mine/4iq6) | Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine | 分子名称: | 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine, Glycogen synthase kinase-3 beta | 著者 | Tong, Y, Stewart, K.D, Florjancic, A.S, Harlan, J.E, Merta, P.J, Przytulinska, M, Soni, N, Swinger, K.S, Zhu, H, Johnson, E.F, Shoemaker, A.R, Penning, T.D. | 登録日 | 2013-01-10 | 公開日 | 2013-04-24 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195. ACS Med Chem Lett, 4, 2013
|
|
4IM2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4im2 by Molmil](/molmil-images/mine/4im2) | Structure of Tank-Binding Kinase 1 | 分子名称: | CHLORIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1 | 著者 | Tu, D, Eck, M.J. | 登録日 | 2013-01-01 | 公開日 | 2013-03-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.5001 Å) | 主引用文献 | Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep, 3, 2013
|
|
4IM0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4im0 by Molmil](/molmil-images/mine/4im0) | Structure of Tank-Binding Kinase 1 | 分子名称: | N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, Serine/threonine-protein kinase TBK1 | 著者 | Tu, D, Eck, M.J. | 登録日 | 2013-01-01 | 公開日 | 2013-03-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4001 Å) | 主引用文献 | Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep, 3, 2013
|
|
1TI7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ti7 by Molmil](/molmil-images/mine/1ti7) | CRYSTAL STRUCTURE OF NMRA, A NEGATIVE TRANSCRIPTIONAL REGULATOR, IN COMPLEX WITH NADP AT 1.7A RESOLUTION | 分子名称: | CHLORIDE ION, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Lamb, H.K, Leslie, K, Dodds, A.L, Nutley, M, Cooper, A, Johnson, C, Thompson, P, Stammers, D.K, Hawkins, A.R. | 登録日 | 2004-06-02 | 公開日 | 2004-06-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides. J.Biol.Chem., 278, 2003
|
|
7AD8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ad8 by Molmil](/molmil-images/mine/7ad8) | Core TFIIH-XPA-DNA complex with modelled p62 subunit | 分子名称: | DNA (49-MER), DNA repair protein complementing XP-A cells, General transcription and DNA repair factor IIH helicase subunit XPB, ... | 著者 | Koelmel, W, Kuper, J, Kisker, C. | 登録日 | 2020-09-14 | 公開日 | 2021-07-28 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | The TFIIH subunits p44/p62 act as a damage sensor during nucleotide excision repair. Nucleic Acids Res., 48, 2020
|
|
8EVJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8evj by Molmil](/molmil-images/mine/8evj) | CX3CR1 nucleosome bound PU.1 and C/EBPa | 分子名称: | DNA (167-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | 著者 | Guan, R, Bai, Y, Lian, T. | 登録日 | 2022-10-20 | 公開日 | 2023-11-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha. Nat.Struct.Mol.Biol., 31, 2024
|
|
8EVH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8evh by Molmil](/molmil-images/mine/8evh) | CX3CR1 nucleosome and wild type PU.1 complex | 分子名称: | DNA (162-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | 著者 | Lian, T, Guan, R, Bai, Y. | 登録日 | 2022-10-20 | 公開日 | 2023-11-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha. Nat.Struct.Mol.Biol., 31, 2024
|
|
6IN9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6in9 by Molmil](/molmil-images/mine/6in9) | |
3EOC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3eoc by Molmil](/molmil-images/mine/3eoc) | Cdk2/CyclinA complexed with a imidazo triazin-2-amine | 分子名称: | 5-methyl-7-phenyl-N-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine, Cell division protein kinase 2, Cyclin-A2 | 著者 | Cheung, M, Kuntz, K, Pobanz, M, Salovich, J, Wilson, B, Andrews, W, Shewchuk, L, Epperly, A, Hassler, D, Leesnitzer, M, Smith, J, Smith, G, Lansing, T, Mook, R. | 登録日 | 2008-09-26 | 公開日 | 2008-11-04 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1. Bioorg.Med.Chem.Lett., 18, 2008
|
|
3EID
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3eid by Molmil](/molmil-images/mine/3eid) | CDK2/CyclinA complexed with a pyrazolopyridazine inhibitor | 分子名称: | (2S)-1-(dimethylamino)-3-(4-{[4-(6-morpholin-4-ylpyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-yl]amino}phenoxy)propan-2-ol, Cell division protein kinase 2, Cyclin-A2 | 著者 | Steven, K, Reno, M, Alberti, J, Price, D, Kane-Carson, L, Knick, V, Shewchuk, L, Hassell, A, Veal, J, Peel, M. | 登録日 | 2008-09-15 | 公開日 | 2008-10-21 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
|
|
3EQ5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3eq5 by Molmil](/molmil-images/mine/3eq5) | Crystal structure of fragment 137 to 238 of the human Ski-like protein | 分子名称: | Ski-like protein | 著者 | Tresaugues, L, Wisniewska, M, Andersson, J, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Dahlgren, L.G, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Lehtio, L, Moche, M, Nilsson, M.E, Nyman, T, Olesen, K, Persson, C, Sagemark, J, Schueler, H, Thorsell, A.G, Van Den Berg, S, Welin, M, Wikstrom, M, Weigelt, J, Nordlund, P, Structural Genomics Consortium (SGC) | 登録日 | 2008-09-30 | 公開日 | 2009-01-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Crystal structure of fragment 137 to 238 of the human Ski-like protein. To be Published
|
|
4UXN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4uxn by Molmil](/molmil-images/mine/4uxn) | LSD1(KDM1A)-CoREST in complex with Z-Pro derivative of MC2580 | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, ... | 著者 | Rodriguez, V, Valente, S, Stazi, G, Lucidi, A, Mercurio, C, Vianello, P, Ciossani, G, Mattevi, A, Botrugno, O.A, Dessanti, P, Minucci, S, Varasi, M, Mai, A. | 登録日 | 2014-08-27 | 公開日 | 2015-02-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Pyrrole- and Indole-Containing Tranylcypromine Derivatives as Novel Lysine-Specific Demethylase 1 Inhibitors Active on Cancer Cells Chemmedchem, 6, 2015
|
|
3EED
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3eed by Molmil](/molmil-images/mine/3eed) | Crystal structure of human protein kinase CK2 regulatory subunit (CK2beta; mutant 1-193) | 分子名称: | Casein kinase II subunit beta, SULFATE ION, ZINC ION | 著者 | Niefind, K, Raaf, J, Issinger, O.-G. | 登録日 | 2008-09-04 | 公開日 | 2008-09-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The interaction of CK2{alpha} and CK2{beta}, the subunits of protein kinase CK2, requires CK2{beta} in a preformed conformation and is enthalpically driven Protein Sci., 17, 2008
|
|
3F06
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3f06 by Molmil](/molmil-images/mine/3f06) | Crystal Structure Analysis of Human HDAC8 D101A Variant. | 分子名称: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, BETA-MERCAPTOETHANOL, Histone deacetylase 8, ... | 著者 | Dowling, D.P, Gantt, S.L, Gattis, S.G, Fierke, C.A, Christianson, D.W. | 登録日 | 2008-10-24 | 公開日 | 2008-12-30 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47, 2008
|
|
6IYC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6iyc by Molmil](/molmil-images/mine/6iyc) | Recognition of the Amyloid Precursor Protein by Human gamma-secretase | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhou, R, Yang, G, Guo, X, Zhou, Q, Lei, J, Shi, Y. | 登録日 | 2018-12-14 | 公開日 | 2019-01-23 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Recognition of the amyloid precursor protein by human gamma-secretase. Science, 363, 2019
|
|
8EVI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8evi by Molmil](/molmil-images/mine/8evi) | CX3CR1 nucleosome and PU.1 complex containing disulfide bond mutations | 分子名称: | DNA (167-MER), Histone H2A type 2-C, Histone H2B type 2-E, ... | 著者 | Lian, T, Guan, R, Bai, Y. | 登録日 | 2022-10-20 | 公開日 | 2023-11-01 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Structural mechanism of synergistic targeting of the CX3CR1 nucleosome by PU.1 and C/EBP alpha. Nat.Struct.Mol.Biol., 31, 2024
|
|
6W66
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6w66 by Molmil](/molmil-images/mine/6w66) | The structure of the F64A, S172A mutant Keap1-BTB domain in complex with SKP1-FBXL17 | 分子名称: | F-box/LRR-repeat protein 17, Kelch-like ECH-associated protein 1, S-phase kinase-associated protein 1 | 著者 | Mena, E.L, Gee, C.L, Kuriyan, J, Rape, M. | 登録日 | 2020-03-16 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.21 Å) | 主引用文献 | Structural basis for dimerization quality control. Nature, 586, 2020
|
|