3F06
Crystal Structure Analysis of Human HDAC8 D101A Variant.
Summary for 3F06
Entry DOI | 10.2210/pdb3f06/pdb |
Related | 3EW8 3EZP 3EZT 3F07 3F0R |
Descriptor | Histone deacetylase 8, ZINC ION, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | hydrolase, hdac, metalloenzyme, arginase fold, hdac8, histone deacetylase 8, hydroxamate inhibitor, mutant, chromatin regulator, nucleus, repressor, transcription, transcription regulation |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q9BY41 |
Total number of polymer chains | 2 |
Total formula weight | 87320.12 |
Authors | Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. (deposition date: 2008-10-24, release date: 2008-12-30, Last modification date: 2023-09-06) |
Primary citation | Dowling, D.P.,Gantt, S.L.,Gattis, S.G.,Fierke, C.A.,Christianson, D.W. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors. Biochemistry, 47:13554-13563, 2008 Cited by PubMed: 19053282DOI: 10.1021/bi801610c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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