PDB: 47720 件ウェブページステータス検索Chemie searchBIRD

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4XRZ	Human Cytochrome P450 2D6 BACE1 Inhibitor 6 Complex 分子名称: (4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(1H-pyrazol-4-yl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine, Cytochrome P450 2D6, GLYCEROL, ... 著者 Johnson, E.F, Fan, Y. 登録日 2015-01-21 公開日 2015-05-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug-Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors. J.Med.Chem., 58, 2015
3G04	Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HUMAN THYROID STIMULATING AUTOANTIBODY M22 HEAVY CHAIN, HUMAN THYROID STIMULATING AUTOANTIBODY M22 LIGHT CHAIN, ... 著者 Sanders, J, Chirgadze, D.Y, Sanders, P, Baker, S, Sullivan, A, Bhardwaja, A, Bolton, J, Reeve, M, Nakatake, N, Evans, M, Richards, T, Powell, M, Miguel, R.N, Blundell, T.L, Furmaniak, J, Smith, B.R. 登録日 2009-01-27 公開日 2009-08-04 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody Thyroid, 17, 2007
4R1Z	Zebra fish cytochrome P450 17A1 with Abiraterone 分子名称: Abiraterone, Cyp17a1 protein, PROTOPORPHYRIN IX CONTAINING FE 著者 Pallan, P.S, Egli, M. 登録日 2014-08-08 公開日 2014-12-31 最終更新日 2015-03-04 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2. J.Biol.Chem., 290, 2015
2WSS	The structure of the membrane extrinsic region of bovine ATP synthase 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL, ... 著者 Rees, D.M, Leslie, A.G.W, Walker, J.E. 登録日 2009-09-09 公開日 2009-11-17 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The Structure of the Membrane Extrinsic Region of Bovine ATP Synthase Proc.Natl.Acad.Sci.USA, 106, 2009
4DUE	cytochrome P450 BM3h-2G9C6 MRI sensor bound to serotonin 分子名称: PROTOPORPHYRIN IX CONTAINING FE, SEROTONIN, cytochrome P450 BM3 variant 2G9C6 著者 Brustad, E.M, Lelyveld, V.S, Snow, C.D, Crook, N, Martinez, F.M, Scholl, T.J, Jasanoff, A, Arnold, F.H. 登録日 2012-02-21 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-guided directed evolution of highly selective p450-based magnetic resonance imaging sensors for dopamine and serotonin. J.Mol.Biol., 422, 2012
4YHH	Crystal structure of the 30S ribosomal subunit from Thermus thermophilus in complex with tigecycline 分子名称: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... 著者 Schedlbauer, A, Kaminishi, T, Ochoa-Lizarralde, B, Dhimole, N, Zhou, S, Lopez-Alonso, J.P, Connell, S.R, Fucini, P. 登録日 2015-02-27 公開日 2015-04-08 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.417 Å) 主引用文献 Structural characterization of an alternative mode of tigecycline binding to the bacterial ribosome. Antimicrob.Agents Chemother., 59, 2015
3HLL	Crystal Structure of Human p38alpha complexed with PH-797804 分子名称: 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, 3-{3-bromo-4-[(2,4-difluorobenzyl)oxy]-6-methyl-2-oxopyridin-1(2H)-yl}-N,4-dimethylbenzamide, HYPOPHOSPHITE, ... 著者 Shieh, H.-S, Williams, J.M, Stegeman, R.A, Kurumbail, R.G. 登録日 2009-05-27 公開日 2009-07-14 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804. Biochemistry, 48, 2009
2W6I	Low resolution structures of bovine mitochondrial F1-ATPase during controlled dehydration: Hydration State 4B. 分子名称: ATP SYNTHASE SUBUNIT ALPHA HEART ISOFORM, MITOCHONDRIAL, ATP SYNTHASE SUBUNIT BETA, ... 著者 Sanchez-Weatherby, J, Felisaz, F, Gobbo, A, Huet, J, Ravelli, R.B.G, Bowler, M.W, Cipriani, F. 登録日 2008-12-18 公開日 2009-10-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Improving diffraction by humidity control: a novel device compatible with X-ray beamlines. Acta Crystallogr. D Biol. Crystallogr., 65, 2009
4G98	Rat Heme Oxygenase-1 in complex with Heme and CO at 100K 分子名称: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-23 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
2W6E	Low resolution structures of bovine mitochondrial F1-ATPase during controlled dehydration:hydration state 1. 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP SYNTHASE SUBUNIT ALPHA HEART ISOFORM, MITOCHONDRIAL, ... 著者 Sanchez-Weatherby, J, Felisaz, F, Gobbo, A, Huet, J, Ravelli, R.B.G, Bowler, M.W, Cipriani, F. 登録日 2008-12-18 公開日 2009-10-27 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (6.5 Å) 主引用文献 Improving Diffraction by Humidity Control: A Novel Device Compatible with X-Ray Beamlines. Acta Crystallogr.,Sect.D, 65, 2009
4G7T	Rat Heme Oxygenase-1 in complex with Heme and CO with 1 hr Illumination: Laser on 分子名称: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-20 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
5T4P	Autoinhibited E. coli ATP synthase state 2 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... 著者 Sobti, M, Smits, C, Wong, A.S.W, Ishmukhametov, R, Stock, D, Sandin, S, Stewart, A.G. 登録日 2016-08-29 公開日 2016-12-28 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (7.77 Å) 主引用文献 Cryo-EM structures of the autoinhibitedE. coliATP synthase in three rotational states. Elife, 5, 2016
4YQY	Crystal Structure of a putative Dehydrogenase from Sulfitobacter sp. (COG1028) (TARGET EFI-513936) in its APO form 分子名称: MAGNESIUM ION, Putative Dehydrogenase 著者 Yadava, U, Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Koss, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) 登録日 2015-03-13 公開日 2015-03-25 実験手法 X-RAY DIFFRACTION (1.381 Å) 主引用文献 Crystal Structure of a putative Dehydrogenase from Sulfitobacter sp. (COG1028, TARGET EFI-513936) in its APO form To be published
2WWV	NMR structure of the IIAchitobiose-IIBchitobiose complex of the N,N'- diacetylchitoboise brance of the E. coli phosphotransferase system. 分子名称: N,N'-DIACETYLCHITOBIOSE-SPECIFIC PHOSPHOTRANSFERASE ENZYME IIA COMPONENT, N,N'-DIACETYLCHITOBIOSE-SPECIFIC PHOSPHOTRANSFERASE ENZYME IIB COMPONENT 著者 Sang, Y.S, Cai, M, Clore, G.M. 登録日 2009-10-29 公開日 2009-12-08 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution Structure of the Iiachitobose-Iibchitobiose Complex of the N,N'-Diacetylchitobiose Branch of the Escherichia Coli Phosphotransfer System J.Biol.Chem., 285, 2010
4DVF	Crystal structure of BACE1 with its inhibitor 分子名称: Beta-secretase 1, METHYL (2S)-1-[(2R,5S,8S,12S,13S)-2,13-DIBENZYL-12-HYDROXY-3,5-DIMETHYL-8-(2-METHYLPROPYL)-15-(3-[(METHYLSULFONYL)AMINO]-5-{[(1R)-1-PHENYLETHYL]CARBAMOYL}PHENYL)-4,7,10,15-TETRAOXO-3,6,9,14-TETRAAZAPENTADECAN-1-OYL]PYRROLIDINE-2-CARBOXYLATE 著者 Xu, Y.C, Chen, W.Y, Li, L, Chen, T.T. 登録日 2012-02-23 公開日 2013-01-16 最終更新日 2021-09-15 実験手法 X-RAY DIFFRACTION (1.803 Å) 主引用文献 Cyanobacterial Peptides as a Prototype for the Design of Potent beta-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases J.Med.Chem., 55, 2012
5T4Q	Autoinhibited E. coli ATP synthase state 3 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... 著者 Sobti, M, Smits, C, Wong, A.S.W, Ishmukhametov, R, Stock, D, Sandin, S, Stewart, A.G. 登録日 2016-08-29 公開日 2017-01-04 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (8.53 Å) 主引用文献 Cryo-EM structures of the autoinhibitedE. coliATP synthase in three rotational states. Elife, 5, 2016
5TFU	Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex 分子名称: (4S,6R)-4-[2,4-difluoro-5-({[1-(trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Hsu, M.H, Johnson, E.F. 登録日 2016-09-26 公開日 2017-01-11 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality. J. Med. Chem., 60, 2017
4DI5	Co-crystal structure of WT 5-epi-Aristolochene synthase from Nicotiana tobaccum with geraniline 分子名称: 5-epi-aristolochene synthase, ACETATE ION, DIPHOSPHATE, ... 著者 Noel, J.P, Starks, C, Crenshaw, C.M. 登録日 2012-01-30 公開日 2012-02-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Co-crystal structure of WT 5-epi-Aristolochene synthase from Nicotiana tobaccum with geraniline To be Published
4G8U	Rat Heme Oxygenase-1 in complex with Heme and O2 with 13 hr illumination: Laser off 分子名称: FORMIC ACID, Heme oxygenase 1, OXYGEN MOLECULE, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-23 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
5CSL	Crystal structure of the 500 kD yeast acetyl-CoA carboxylase holoenzyme dimer 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Acetyl-CoA carboxylase, COENZYME A 著者 Wei, J, Tong, L. 登録日 2015-07-23 公開日 2015-10-28 最終更新日 2022-03-23 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer. Nature, 526, 2015
5UOJ	THE STRUCTURE OF THE MAP KINASE P38 AT 2.1 ANGSTROMS RESOLUTION 分子名称: Mitogen-activated protein kinase 14 著者 CHLEBOWICZ, J, WANG, Z, GOLDSMITH, E.J. 登録日 2017-01-31 公開日 2017-02-22 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc. Natl. Acad. Sci. U.S.A., 94, 1997
4G7P	Rat Heme Oxygenase-1 in complex with Heme and CO with 1 hr Illumination at 100 K: Laser off 分子名称: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-20 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
4G8P	Rat Heme Oxygenase-1 in complex with Heme and CO with 16 hr Illumination: Laser on 分子名称: CARBON MONOXIDE, FORMIC ACID, Heme oxygenase 1, ... 著者 Sugishima, M, Moffat, K, Noguchi, M. 登録日 2012-07-23 公開日 2012-10-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discrimination between CO and O(2) in heme oxygenase: comparison of static structures and dynamic conformation changes following CO photolysis. Biochemistry, 51, 2012
5CSK	Crystal structure of yeast acetyl-CoA carboxylase, unbiotinylated 分子名称: Acetyl-CoA carboxylase 著者 Wei, J, Tong, L. 登録日 2015-07-23 公開日 2015-10-28 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer. Nature, 526, 2015
4Z4A	Avirulence protein 4 (Avr4) from Pseudocercospora fuligena 分子名称: 1,2-ETHANEDIOL, Carbohydrate-binding module family 14 protein 著者 Hurlburt, N.K, Kohler, A.C, Fisher, A.J. 登録日 2015-04-01 公開日 2016-06-29 最終更新日 2016-09-14 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Analysis of an Avr4 Effector Ortholog Offers Insight into Chitin Binding and Recognition by the Cf-4 Receptor. Plant Cell, 28, 2016

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