4R1Z

Zebra fish cytochrome P450 17A1 with Abiraterone

Summary for 4R1Z

• Entry DOI: 10.2210/pdb4r1z/pdb
• Related: 4R20 4R21
• Descriptor: Cyp17a1 protein, PROTOPORPHYRIN IX CONTAINING FE, Abiraterone, ... (4 entities in total)
• Functional Keywords: cytochrome p450 17a1, abiraterone, 17 (alpha)-hydroxylation, 17alpha, 20-lyase, steroid biosynthesis, enzyme kinetics, oxidoreductase
• Biological source: Danio rerio (leopard danio,zebra danio,zebra fish)
• Total number of polymer chains: 2
• Total formula weight: 101132.17

Authors

Pallan, P.S.,Egli, M. (deposition date: 2014-08-08, release date: 2014-12-31, Last modification date: 2015-03-04)

• Primary citation: Pallan, P.S.,Nagy, L.D.,Lei, L.,Gonzalez, E.,Kramlinger, V.M.,Azumaya, C.M.,Wawrzak, Z.,Waterman, M.R.,Guengerich, F.P.,Egli, M.; Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.; J.Biol.Chem., 290:3248-3268, 2015; PubMed: 25533464; DOI: 10.1074/jbc.M114.627265

Experimental method

X-RAY DIFFRACTION (3.3 Å)