4WHX
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![BU of 4whx by Molmil](/molmil-images/mine/4whx) | X-ray Crystal Structure of an Amino Acid Aminotransferase from Burkholderia pseudomallei Bound to the Co-factor Pyridoxal Phosphate | 分子名称: | 1,2-ETHANEDIOL, ALANINE, Branched-chain-amino-acid transaminase | 著者 | Seattle Structural Genomics Center for Infectious Disease (SSGCID), Fairman, J.W, Dranow, D.M, Taylor, B.M, Lorimer, D, Edwards, T.E. | 登録日 | 2014-09-23 | 公開日 | 2014-10-08 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | X-ray Crystal Structure of an Amino Acid Aminotransferase from Burkholderia pseudomallei Bound to the Co-factor Pyridoxal Phosphate to be published
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4WQ2
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![BU of 4wq2 by Molmil](/molmil-images/mine/4wq2) | Human calpain PEF(S) with (Z)-3-(6-bromondol-3-yl)-2-mercaptoacrylic acid bound | 分子名称: | (2Z)-3-(6-bromo-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid, 1,2-ETHANEDIOL, CALCIUM ION, ... | 著者 | Adams, S.E, Rizkallah, P.J, Miller, D.J, Hallett, M.B, Allemann, R.K. | 登録日 | 2014-10-21 | 公開日 | 2015-09-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Conformationally restricted calpain inhibitors. Chem Sci, 6, 2015
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8TJ3
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1R0W
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![BU of 1r0w by Molmil](/molmil-images/mine/1r0w) | Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) apo | 分子名称: | ACETIC ACID, Cystic fibrosis transmembrane conductance regulator | 著者 | Lewis, H.A, Buchanan, S.G, Burley, S.K, Conners, K, Dickey, M, Dorwart, M, Fowler, R, Gao, X, Guggino, W.B, Hendrickson, W.A. | 登録日 | 2003-09-23 | 公開日 | 2003-12-09 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. Embo J., 23, 2004
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2AUX
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![BU of 2aux by Molmil](/molmil-images/mine/2aux) | Cathepsin K complexed with a semicarbazone inhibitor | 分子名称: | (1R)-2-METHYL-1-(PHENYLMETHYL)PROPYL[(1S)-1-FORMYLPENTYL]CARBAMATE, Cathepsin K | 著者 | Adkison, K.K, Barrett, D.G, Deaton, D.N, Gampe, R.T, Hassell, A.M, Long, S.T, McFadyen, R.B, Miller, A.B, Miller, L.R, Shewchuk, L.M. | 登録日 | 2005-08-29 | 公開日 | 2006-08-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg.Med.Chem.Lett., 16, 2006
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2LGR
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6WG5
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![BU of 6wg5 by Molmil](/molmil-images/mine/6wg5) | Human ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4, NTPDase 4) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ectonucleoside triphosphate diphosphohydrolase 4 | 著者 | Gorelik, A, Labriola, J.M, Illes, K, Nagar, B. | 登録日 | 2020-04-04 | 公開日 | 2020-08-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of the nucleotide-metabolizing enzyme NTPDase4. Protein Sci., 29, 2020
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2LKQ
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![BU of 2lkq by Molmil](/molmil-images/mine/2lkq) | NMR structure of the lambda 5 22-45 peptide | 分子名称: | Immunoglobulin lambda-like polypeptide 1 | 著者 | Elantak, L, Espeli, M, Boned, A, Bornet, O, Breton, C, Feracci, M, Roche, P, Guerlesquin, F, Schiff, C. | 登録日 | 2011-10-19 | 公開日 | 2012-10-24 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation. J.Biol.Chem., 287, 2012
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6DGN
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2LL8
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![BU of 2ll8 by Molmil](/molmil-images/mine/2ll8) | Solution NMR structure of the specialized holo-acyl carrier protein RPA2022 from Rhodopseudomonas palustris refined with NH RDCs, Northeast Structural Genomics Consortium Target RpR324 | 分子名称: | 4'-PHOSPHOPANTETHEINE, Specialized acyl carrier protein | 著者 | Ramelot, T.A, Ni, S, Rossi, P, Yang, Y, Wang, H, Ciccosanti, C, Maglaqui, M, Janjua, H, Nair, R, Roset, B, Acton, T.B, Xiao, R, Everett, J.K, Prestegard, J.H, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2011-10-31 | 公開日 | 2011-11-30 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of a specialized acyl carrier protein essential for lipid A biosynthesis with very long-chain fatty acids in open and closed conformations. Biochemistry, 51, 2012
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4W7S
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![BU of 4w7s by Molmil](/molmil-images/mine/4w7s) | Crystal structure of the yeast DEAD-box splicing factor Prp28 at 2.54 Angstroms resolution | 分子名称: | GLYCEROL, HEXAETHYLENE GLYCOL, MAGNESIUM ION, ... | 著者 | Jacewicz, A, Smith, P, Schwer, B, Shuman, S. | 登録日 | 2014-08-22 | 公開日 | 2014-10-29 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.542 Å) | 主引用文献 | Crystal structure, mutational analysis and RNA-dependent ATPase activity of the yeast DEAD-box pre-mRNA splicing factor Prp28. Nucleic Acids Res., 42, 2014
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2LE1
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![BU of 2le1 by Molmil](/molmil-images/mine/2le1) | Solution NMR Structure of Tfu_2981 from Thermobifida fusca, Northeast Structural Genomics Consortium Target TfR85A | 分子名称: | Uncharacterized protein | 著者 | Pulavarti, S.V.S.R.K, Eletsky, A, Mills, J.L, Sukumaran, D.K, Wang, D, Ciccosanti, C, Hamilton, K, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Lee, H, Prestegard, J.H, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2011-06-03 | 公開日 | 2011-06-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR Structure of Tfu_2981 from Thermobifida fusca, Northeast Structural Genomics Consortium Target TfR85A To be Published
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2LR8
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![BU of 2lr8 by Molmil](/molmil-images/mine/2lr8) | Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A | 分子名称: | CASP8-associated protein 2 | 著者 | Pulavarti, S, Sathyamoorthy, B, Eletsky, A, Sukumaran, D.K, Lee, D, Kohan, E, Janjua, H, Xiao, R, Acton, T.B, Everett, J.K, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2012-03-27 | 公開日 | 2012-06-27 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR Structure of CASP8-associated protein 2 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR8150A To be Published
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8SE6
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![BU of 8se6 by Molmil](/molmil-images/mine/8se6) | NKG2D complexed with inhibitor 36 | 分子名称: | N-[(1S)-2-(dimethylamino)-2-oxo-1-{3-[3-(2,2,2-trifluoroethyl)azetidin-1-yl]phenyl}ethyl]-4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamide, NKG2-D type II integral membrane protein, TETRAETHYLENE GLYCOL, ... | 著者 | Thompson, A.A, Grant, J.C, Karpowich, N.K, Sharma, S. | 登録日 | 2023-04-08 | 公開日 | 2023-10-11 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D). Bioorg.Med.Chem.Lett., 96, 2023
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3LWP
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![BU of 3lwp by Molmil](/molmil-images/mine/3lwp) | Structure of H/ACA RNP bound to a substrate RNA containing 5BrdU | 分子名称: | 5'-R(*GP*AP*GP*CP*GP*(BRU)P*GP*CP*GP*GP*UP*UP*U)-3, 50S ribosomal protein L7Ae, H/ACA RNA, ... | 著者 | Zhou, J, Liang, B, Lv, C, Yang, W, Li, H. | 登録日 | 2010-02-24 | 公開日 | 2010-07-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Glycosidic bond conformation preference plays a pivotal role in catalysis of RNA pseudouridylation: a combined simulation and structural study. J.Mol.Biol., 401, 2010
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6WOK
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![BU of 6wok by Molmil](/molmil-images/mine/6wok) | Crystal structure of estrogen receptor alpha in complex with receptor degrader 6 | 分子名称: | (1R,3R)-1-(2,6-difluoro-4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-beta-carboline, (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, Estrogen receptor | 著者 | Kiefer, J.R, Vinogradova, M, Liang, J, Zhang, B, Wang, X, Labadie, S. | 登録日 | 2020-04-24 | 公開日 | 2020-07-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.309 Å) | 主引用文献 | Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer. Acs Med.Chem.Lett., 11, 2020
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3LWO
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![BU of 3lwo by Molmil](/molmil-images/mine/3lwo) | Structure of H/ACA RNP bound to a substrate RNA containing 5BrU | 分子名称: | 5'-R(*GP*AP*GP*CP*GP*(5BU)P*GP*CP*GP*GP*UP*UP*U)-3', 50S ribosomal protein L7Ae, H/ACA RNA, ... | 著者 | Zhou, J, Liang, B, Lv, C, Yang, W, Li, H. | 登録日 | 2010-02-24 | 公開日 | 2010-07-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.855 Å) | 主引用文献 | Glycosidic bond conformation preference plays a pivotal role in catalysis of RNA pseudouridylation: a combined simulation and structural study. J.Mol.Biol., 401, 2010
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4TVS
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![BU of 4tvs by Molmil](/molmil-images/mine/4tvs) | LAP1(aa356-583), H.sapiens, bound to VHH-BS1 | 分子名称: | GLYCEROL, SULFATE ION, Torsin-1A-interacting protein 1, ... | 著者 | Sosa, B.A, Schwartz, T.U. | 登録日 | 2014-06-27 | 公開日 | 2014-09-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | How lamina-associated polypeptide 1 (LAP1) activates Torsin. Elife, 3, 2014
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6WYV
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![BU of 6wyv by Molmil](/molmil-images/mine/6wyv) | E. coli 50S ribosome bound to compounds 47 and VS1 | 分子名称: | (3R,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, 23S ribosomal RNA, 50S ribosomal protein L13, ... | 著者 | Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B. | 登録日 | 2020-05-13 | 公開日 | 2020-06-17 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020
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2L21
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![BU of 2l21 by Molmil](/molmil-images/mine/2l21) | chicken IGF2R domain 11 | 分子名称: | Cation-independent mannose-6-phosphate receptor | 著者 | Williams, C, Hoppe, H, Strickland, M, Frago, S, Ellis, R.Z, Wattana-Amorn, P, Prince, S.N, Zaccheo, O.J, Forbes, B, Jones, E.Y, Rezgui, D.Z, Crump, M.P, Hassan, A.B. | 登録日 | 2010-08-10 | 公開日 | 2012-02-15 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | CD loop dependency of the IGF2: M6P/IGF2 receptor binding interaction predates imprinting To be Published
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3LT7
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3LV5
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![BU of 3lv5 by Molmil](/molmil-images/mine/3lv5) | Crystal structure of the mutant I199E of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP | 分子名称: | 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase | 著者 | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | 登録日 | 2010-02-19 | 公開日 | 2010-06-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.444 Å) | 主引用文献 | Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
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4UZN
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![BU of 4uzn by Molmil](/molmil-images/mine/4uzn) | The native structure of the family 46 carbohydrate-binding module (CBM46) of endo-beta-1,4-glucanase B (Cel5B) from Bacillus halodurans | 分子名称: | ENDO-BETA-1,4-GLUCANASE (CELULASE B) | 著者 | Venditto, I, Santos, H, Ferreira, L.M.A, Sakka, K, Fontes, C.M.G.A, Najmudin, S. | 登録日 | 2014-09-05 | 公開日 | 2015-02-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Family 46 Carbohydrate-Binding Modules Contribute to the Enzymatic Hydrolysis of Xyloglucan and Beta-1,3-1,4-Glucans Through Distinct Mechanisms. J.Biol.Chem., 290, 2015
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2LQH
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![BU of 2lqh by Molmil](/molmil-images/mine/2lqh) | NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2b3l conformation) | 分子名称: | CREB-binding protein, Forkhead box O3 | 著者 | Wang, F, Marshall, C.B, Yamamoto, K, Li, G.B, Gasmi-Seabrook, G.M.C, Okada, H, Mak, T.W, Ikura, M. | 登録日 | 2012-03-06 | 公開日 | 2012-05-16 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment. Proc.Natl.Acad.Sci.USA, 109, 2012
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3LV6
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![BU of 3lv6 by Molmil](/molmil-images/mine/3lv6) | Crystal structure of the mutant I218F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP | 分子名称: | 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase | 著者 | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | 登録日 | 2010-02-19 | 公開日 | 2010-06-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.451 Å) | 主引用文献 | Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
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