8ELB
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![BU of 8elb by Molmil](/molmil-images/mine/8elb) | CTX-M-14 beta-lactamase mutant- N132A | 分子名称: | Beta-lactamase, DI(HYDROXYETHYL)ETHER | 著者 | Lu, S, Neetu, N, Palzkill, T. | 登録日 | 2022-09-23 | 公開日 | 2023-04-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
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8EK9
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![BU of 8ek9 by Molmil](/molmil-images/mine/8ek9) | Crystal structure of the class A carbapenemase CRH-1 in complex with avibactam at 1.4 Angstrom resolution | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | 著者 | Power, P, Brunetti, F, Ghiglione, B, Guardabassi, L, Gutkind, G, Klinke, S. | 登録日 | 2022-09-20 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Biochemical and Structural Characterization of CRH-1, a Carbapenemase from Chromobacterium haemolyticum Related to KPC beta-Lactamases. Antimicrob.Agents Chemother., 67, 2023
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8EHU
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![BU of 8ehu by Molmil](/molmil-images/mine/8ehu) | Crystal structure of the environmental CRH-1 class A carbapenemase at 1.1 Angstrom resolution | 分子名称: | Beta-lactamase | 著者 | Power, P, Brunetti, F, Ghiglione, B, Guardabassi, L, Gutkind, G, Klinke, S. | 登録日 | 2022-09-14 | 公開日 | 2023-05-31 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Biochemical and Structural Characterization of CRH-1, a Carbapenemase from Chromobacterium haemolyticum Related to KPC beta-Lactamases. Antimicrob.Agents Chemother., 67, 2023
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8EHH
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![BU of 8ehh by Molmil](/molmil-images/mine/8ehh) | Crystal structure of the class A extended-spectrum beta-lactamase CTX-M-96 in complex with relebactam at 1.03 Angstrom resolution | 分子名称: | (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | 著者 | Power, P, Ghiglione, B, Bonomo, R.A, Rodriguez, M.M, Gutkind, G, Klinke, S. | 登録日 | 2022-09-14 | 公開日 | 2023-09-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | 主引用文献 | Biochemical and structural evidences of the activity of relebactam as inhibitor of the extended-spectrum beta-lactamase CTX-M-96. To be published
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8EO7
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![BU of 8eo7 by Molmil](/molmil-images/mine/8eo7) | Crystal structure of metagenomic beta-lactamase LRA-5 Y69Q/V166E mutant at 2.15 Angstrom resolution | 分子名称: | beta-lactamase | 著者 | Power, P, D'Amico Gonzalez, G, Centron, D, Gutkind, G, Handelsman, J, Klinke, S. | 登録日 | 2022-10-02 | 公開日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions to be published
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8EO6
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![BU of 8eo6 by Molmil](/molmil-images/mine/8eo6) | Crystal structure of metagenomic class A beta-lactamase precursor LRA-5 in complex with ceftazidime at 2.35 Angstrom resolution | 分子名称: | ACYLATED CEFTAZIDIME, LRA-5 | 著者 | Power, P, D'Amico Gonzalez, G, Centron, D, Gutkind, G, Handelsman, J, Klinke, S. | 登録日 | 2022-10-02 | 公開日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions to be published
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8G2R
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![BU of 8g2r by Molmil](/molmil-images/mine/8g2r) | |
8G2T
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![BU of 8g2t by Molmil](/molmil-images/mine/8g2t) | |
1VM1
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![BU of 1vm1 by Molmil](/molmil-images/mine/1vm1) | STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM | 分子名称: | ACRYLIC ACID, BETA-LACTAMASE SHV-1, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, ... | 著者 | Kuzin, A.P, Nukaga, M, Nukaga, Y, Hujer, A, Bonomo, R.A, Knox, J.R. | 登録日 | 2004-08-27 | 公開日 | 2004-09-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Inhibition of the SHV-1 beta-lactamase by sulfones: crystallographic observation of two reaction intermediates with tazobactam. Biochemistry, 40, 2001
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8EO5
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![BU of 8eo5 by Molmil](/molmil-images/mine/8eo5) | Crystal structure of the class A beta-lactamase precursor LRA-5 from an Alaskan soil metagenome at 1.8 Angstrom resolution | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, LRA-5 | 著者 | Power, P, D'Amico Gonzalez, G, Centron, D, Gutkind, G, Handelsman, J, Klinke, S. | 登録日 | 2022-10-02 | 公開日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Playing beta-Lactamase Evolution: Metagenomic Class A beta-Lactamase LRA-5 is an Inactive Enzyme Capable of Rendering an Active beta-Lactamase by Introduction of Y69Q and V166E Substitutions to be published
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8GCV
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![BU of 8gcv by Molmil](/molmil-images/mine/8gcv) | |
8GCT
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![BU of 8gct by Molmil](/molmil-images/mine/8gct) | |
8GCS
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![BU of 8gcs by Molmil](/molmil-images/mine/8gcs) | |
8GCX
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![BU of 8gcx by Molmil](/molmil-images/mine/8gcx) | |
1YLJ
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![BU of 1ylj by Molmil](/molmil-images/mine/1ylj) | Atomic resolution structure of CTX-M-9 beta-lactamase | 分子名称: | SULFATE ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, beta-lactamase CTX-M-9a | 著者 | Chen, Y, Delmas, J, Sirot, J, Shoichet, B, Bonnet, R. | 登録日 | 2005-01-19 | 公開日 | 2005-04-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (0.98 Å) | 主引用文献 | Atomic Resolution Structures of CTX-M beta-Lactamases: Extended Spectrum Activities from Increased Mobility and Decreased Stability. J.Mol.Biol., 348, 2005
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1YLY
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![BU of 1yly by Molmil](/molmil-images/mine/1yly) | X-ray crystallographic structure of CTX-M-9 beta-lactamase complexed with ceftazidime-like boronic acid | 分子名称: | PHOSPHATE ION, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, beta-lactamase CTX-M-9 | 著者 | Chen, Y, Shoichet, B, Bonnet, R. | 登録日 | 2005-01-19 | 公開日 | 2005-04-26 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Structure, Function, and Inhibition along the Reaction Coordinate of CTX-M beta-Lactamases. J.Am.Chem.Soc., 127, 2005
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1YLP
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![BU of 1ylp by Molmil](/molmil-images/mine/1ylp) | Atomic resolution structure of CTX-M-27 beta-lactamase | 分子名称: | SULFATE ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, beta-lactamase CTX-M-27 | 著者 | Chen, Y, Delmas, J, Sirot, J, Shoichet, B, Bonnet, R. | 登録日 | 2005-01-19 | 公開日 | 2005-04-19 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Atomic Resolution Structures of CTX-M beta-Lactamases: Extended Spectrum Activities from Increased Mobility and Decreased Stability. J.Mol.Biol., 348, 2005
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1YLZ
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![BU of 1ylz by Molmil](/molmil-images/mine/1ylz) | X-ray crystallographic structure of CTX-M-14 beta-lactamase complexed with ceftazidime-like boronic acid | 分子名称: | BETA-LACTAMASE CTX-M-14, PHOSPHATE ION, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE | 著者 | Chen, Y, Shoichet, B, Bonnet, R. | 登録日 | 2005-01-19 | 公開日 | 2005-04-26 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Structure, Function, and Inhibition along the Reaction Coordinate of CTX-M beta-Lactamases. J.Am.Chem.Soc., 127, 2005
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1YMX
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![BU of 1ymx by Molmil](/molmil-images/mine/1ymx) | X-ray crystallographic structure of CTX-M-9 beta-lactamase covalently linked to cefoxitin | 分子名称: | (2R)-5-[(carbamoyloxy)methyl]-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, beta-lactamase CTX-M-9 | 著者 | Chen, Y, Shoichet, B, Bonnet, R. | 登録日 | 2005-01-21 | 公開日 | 2005-04-26 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure, Function, and Inhibition along the Reaction Coordinate of CTX-M beta-Lactamases. J.Am.Chem.Soc., 127, 2005
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1YMS
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![BU of 1yms by Molmil](/molmil-images/mine/1yms) | X-ray crystallographic structure of CTX-M-9 beta-lactamase complexed with nafcinin-like boronic acid inhibitor | 分子名称: | [(2-ETHOXY-1-NAPHTHOYL)AMINO]METHYLBORONIC ACID, beta-lactamase CTX-M-9 | 著者 | Chen, Y, Shoichet, B, Bonnet, R. | 登録日 | 2005-01-21 | 公開日 | 2005-04-26 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure, Function, and Inhibition along the Reaction Coordinate of CTX-M beta-Lactamases. J.Am.Chem.Soc., 127, 2005
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1YLT
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![BU of 1ylt by Molmil](/molmil-images/mine/1ylt) | Atomic resolution structure of CTX-M-14 beta-lactamase | 分子名称: | SULFATE ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, beta-lactamase CTX-M-14 | 著者 | Chen, Y, Delmas, J, Sirot, J, Shoichet, B, Bonnet, R. | 登録日 | 2005-01-19 | 公開日 | 2005-04-19 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Atomic Resolution Structures of CTX-M beta-Lactamases: Extended Spectrum Activities from Increased Mobility and Decreased Stability. J.Mol.Biol., 348, 2005
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1YM1
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![BU of 1ym1 by Molmil](/molmil-images/mine/1ym1) | X-ray crystallographic structure of CTX-M-9 beta-lactamase complexed with a boronic acid inhibitor (SM2) | 分子名称: | (1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID, PHOSPHATE ION, beta-lactamase CTX-M-9a | 著者 | Chen, Y, Shoichet, B, Bonnet, R. | 登録日 | 2005-01-20 | 公開日 | 2005-04-26 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Structure, Function, and Inhibition along the Reaction Coordinate of CTX-M beta-Lactamases. J.Am.Chem.Soc., 127, 2005
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1XXM
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![BU of 1xxm by Molmil](/molmil-images/mine/1xxm) | The modular architecture of protein-protein binding site | 分子名称: | Beta-lactamase TEM, Beta-lactamase inhibitory protein, CALCIUM ION | 著者 | Reichmann, D, Rahat, O, Albeck, S, Meged, R, Dym, O, Schreiber, G, Israel Structural Proteomics Center (ISPC) | 登録日 | 2004-11-07 | 公開日 | 2005-01-18 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The modular architecture of protein-protein binding interfaces Proc.Natl.Acad.Sci.USA, 102, 2005
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1YLW
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![BU of 1ylw by Molmil](/molmil-images/mine/1ylw) | X-ray structure of CTX-M-16 beta-lactamase | 分子名称: | CTX-M-16 beta-lactamase, SULFATE ION | 著者 | Chen, Y, Delmas, J, Sirot, J, Shoichet, B, Bonnet, R. | 登録日 | 2005-01-19 | 公開日 | 2005-04-19 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Atomic Resolution Structures of CTX-M beta-Lactamases: Extended Spectrum Activities from Increased Mobility and Decreased Stability. J.Mol.Biol., 348, 2005
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1XPB
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![BU of 1xpb by Molmil](/molmil-images/mine/1xpb) | STRUCTURE OF BETA-LACTAMASE TEM1 | 分子名称: | BETA-LACTAMASE, SULFATE ION | 著者 | Fonze, E, Charlier, P. | 登録日 | 1997-01-10 | 公開日 | 1997-04-01 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | TEM1 beta-lactamase structure solved by molecular replacement and refined structure of the S235A mutant. Acta Crystallogr.,Sect.D, 51, 1995
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