8G2T
CRYSTAL STRUCTURE OF THE KPC-2 D179N VARIANT IN COMPLEX WITH RELEBACTAM (IMINE HYDROLYSIS INTERMEDIATE)
Summary for 8G2T
| Entry DOI | 10.2210/pdb8g2t/pdb |
| Related | 8G2R |
| Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, (2S,5R)-5-amino-1-formyl-5-hydroxy-N-(piperidin-4-yl)piperidine-2-carboxamide, PHOSPHATE ION, ... (4 entities in total) |
| Functional Keywords | beta-lactamase, inhibitor, antibiotic resistance, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
| Biological source | Klebsiella pneumoniae |
| Total number of polymer chains | 1 |
| Total formula weight | 28541.05 |
| Authors | Alsenani, T.,van den Akker, F. (deposition date: 2023-02-06, release date: 2023-08-09, Last modification date: 2023-11-01) |
| Primary citation | Alsenani, T.A.,Viviani, S.L.,Papp-Wallace, K.M.,Bonomo, R.A.,van den Akker, F. Exploring avibactam and relebactam inhibition of Klebsiella pneumoniae carbapenemase D179N variant: role of the Omega loop-held deacylation water. Antimicrob.Agents Chemother., 67:e0035023-e0035023, 2023 Cited by PubMed: 37750722DOI: 10.1128/aac.00350-23 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.26 Å) |
Structure validation
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