8G2T
CRYSTAL STRUCTURE OF THE KPC-2 D179N VARIANT IN COMPLEX WITH RELEBACTAM (IMINE HYDROLYSIS INTERMEDIATE)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbapenem-hydrolyzing beta-lactamase KPC | polymer | 266 | 28175.8 | 1 | UniProt (Q9F663) Pfam (PF00144) Pfam (PF13354) | Klebsiella pneumoniae | Carbapenem-hydrolyzing beta-lactamase KPC-1 |
| 2 | B (A) | (2S,5R)-5-amino-1-formyl-5-hydroxy-N-(piperidin-4-yl)piperidine-2-carboxamide | non-polymer | 270.3 | 1 | Chemie (YOZ) | |||
| 3 | C (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 4 | D (A) | water | water | 18.0 | 376 | Chemie (HOH) |
Sequence modifications
A: 24 - 291 (UniProt: Q9F663)
| PDB | External Database | Details |
|---|---|---|
| Asn 179 | Asp 178 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28175.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 365.3 | |
| All* | Total formula weight | 28541.1 |
