PDB: 22592 件ウェブページステータス検索Chemie searchBIRD

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6CCD	The crystal structure of Mycobacterium tuberculosis Rv1747 FHA-1 分子名称: ABC transporter ATP-binding/permease protein Rv1747, SULFATE ION 著者 Gay, L.M, Gee, C.L, Alber, T. 登録日 2018-02-06 公開日 2018-06-20 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Biophysical Characterization of the Tandem FHA Domain Regulatory Module from the Mycobacterium tuberculosis ABC Transporter Rv1747. Structure, 26, 2018
6SGZ	Structure of protomer 2 of the ESX-3 core complex 分子名称: ESX-3 secretion system ATPase EccB3, ESX-3 secretion system protein EccC3, ESX-3 secretion system protein EccD3, ... 著者 Famelis, N, Rivera-Calzada, A, Llorca, O, Geibel, S. 登録日 2019-08-05 公開日 2019-10-09 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Architecture of the mycobacterial type VII secretion system. Nature, 576, 2019
6CYJ	Mycobacterium tuberculosis transcriptional regulator 分子名称: HTH-type transcriptional regulator PrpR, IRON/SULFUR CLUSTER, SUCCINYL-COENZYME A 著者 Tang, S, Sacchettini, J. 登録日 2018-04-05 公開日 2019-04-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.699 Å) 主引用文献 Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor. Nucleic Acids Res., 47, 2019
6CZ6	Mycobacterium tuberculosis transcriptional regulator 分子名称: COENZYME A, HTH-type transcriptional regulator PrpR, IRON/SULFUR CLUSTER 著者 Tang, S, Sacchettini, J. 登録日 2018-04-08 公開日 2019-04-17 最終更新日 2019-10-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor. Nucleic Acids Res., 47, 2019
6DE5	Mycobacterium tuberculosis Rv2671 complexed with beta-NADPH and 6-ethyl-5-{(3S)-3-[2-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine 分子名称: 6-ethyl-5-{(3S)-3-[2-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, riboflavin biosynthesis protein RibD 著者 Hajian, B, Wright, D. 登録日 2018-05-11 公開日 2018-05-23 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents. Cell Chem Biol, 26, 2019
5KEI	Mycobacterium smegmatis MbtA apo structure 分子名称: 2,3-dihydroxybenzoate-AMP ligase 著者 Favrot, L, Vergnolle, O, Blanchard, J.S. 登録日 2016-06-09 公開日 2016-09-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.325 Å) 主引用文献 Post-translational Acetylation of MbtA Modulates Mycobacterial Siderophore Biosynthesis. J.Biol.Chem., 291, 2016
7PU7	DNA polymerase from M. tuberculosis 分子名称: DNA polymerase III subunit alpha, Template, ZINC ION, ... 著者 Borsellini, A, Lamers, M.H. 登録日 2021-09-28 公開日 2022-02-23 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in Mycobacterium tuberculosis. Acs Infect Dis., 8, 2022
5LIE	Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with imidazole 分子名称: IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450 126 著者 Levy, C, Munro, A.W, Leys, D. 登録日 2016-07-14 公開日 2016-12-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1. J. Biol. Chem., 292, 2017
6SGW	Structure of the ESX-3 core complex 分子名称: ESX-3 secretion system ATPase EccB3, ESX-3 secretion system protein EccC3, ESX-3 secretion system protein EccD3, ... 著者 Famelis, N, Rivera-Calzada, A, Llorca, O, Geibel, S. 登録日 2019-08-05 公開日 2019-10-09 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Architecture of the mycobacterial type VII secretion system. Nature, 576, 2019
1E0W	Xylanase 10A from Sreptomyces lividans. native structure at 1.2 angstrom resolution 分子名称: ENDO-1,4-BETA-XYLANASE A 著者 Ducros, V, Charnock, S.J, Derewenda, U, Derewenda, Z.S, Dauter, Z, Dupont, C, Shareck, F, Morosoli, R, Kluepfel, D, Davies, G.J. 登録日 2000-04-10 公開日 2001-04-05 最終更新日 2014-02-05 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Substrate Specificity in Glycoside Hydrolase Family 10. Structural and Kinetic Analysis of the Streptomyces Lividans Xylanase 10A J.Biol.Chem., 275, 2000
1E0X	XYLANASE 10A FROM SREPTOMYCES LIVIDANS. XYLOBIOSYL-ENZYME INTERMEDIATE AT 1.65 A 分子名称: ENDO-1,4-BETA-XYLANASE A, GLYCEROL, beta-D-xylopyranose-(1-4)-2-deoxy-2-fluoro-alpha-D-xylopyranose 著者 Ducros, V, Charnock, S.J, Derewenda, U, Derewenda, Z.S, Dauter, Z, Dupont, C, Shareck, F, Morosoli, R, Kluepfel, D, Davies, G.J. 登録日 2000-04-10 公開日 2001-04-05 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Substrate Specificity in Glycoside Hydrolase Family 10. Structural and Kinetic Analysis of the Streptomyces Lividans Xylanase 10A J.Biol.Chem., 275, 2000
1E0V	Xylanase 10A from Sreptomyces lividans. cellobiosyl-enzyme intermediate at 1.7 A 分子名称: ENDO-1,4-BETA-XYLANASE A, beta-D-glucopyranose-(1-4)-2-deoxy-2-fluoro-alpha-D-glucopyranose 著者 Ducros, V, Charnock, S.J, Derewenda, U, Derewenda, Z.S, Dauter, Z, Dupont, C, Shareck, F, Morosoli, R, Kluepfel, D, Davies, G.J. 登録日 2000-04-10 公開日 2001-04-05 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Substrate Specificity in Glycoside Hydrolase Family 10. Structural and Kinetic Analysis of the Streptomyces Lividans Xylanase 10A J.Biol.Chem., 275, 2000
1NH8	ATP PHOSPHORIBOSYLTRANSFERASE (ATP-PRTASE) FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AMP AND HISTIDINE 分子名称: ADENOSINE MONOPHOSPHATE, ATP Phosphoribosyltransferase, HISTIDINE, ... 著者 Cho, Y, Sharma, V, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2002-12-18 公開日 2003-02-11 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis J.Biol.Chem., 278, 2003
8IBO	Crystal structure of Wild-Type Mycobacterium tuberculosis ClpC1 N-terminal domain in complex with Lassomycin 分子名称: ACETATE ION, Lassomycin, Negative regulator of genetic competence ClpC/mecB 著者 Jagdev, M.K, Vasudevan, D. 登録日 2023-02-10 公開日 2023-09-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Crystal structure of the N-terminal domain of MtClpC1 in complex with the anti-mycobacterial natural peptide Lassomycin. Int.J.Biol.Macromol., 253, 2023
8IBP	Crystal structure of Mycobacterium tuberculosis R21K ClpC1 N-terminal domain in complex with Lassomycin 分子名称: ACETATE ION, Lassomycin, Negative regulator of genetic competence ClpC/mecB 著者 Jagdev, M.K, Vasudevan, D. 登録日 2023-02-10 公開日 2023-09-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Crystal structure of the N-terminal domain of MtClpC1 in complex with the anti-mycobacterial natural peptide Lassomycin. Int.J.Biol.Macromol., 253, 2023
5W8O	Homoserine transacetylase MetX from Mycobacterium hassiacum 分子名称: CALCIUM ION, GLYCEROL, Homoserine O-acetyltransferase, ... 著者 Reed, R.W, Rodriguez, E.S, Li, J, Korotkov, K.V. 登録日 2017-06-22 公開日 2017-07-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Structural analysis of mycobacterial homoserine transacetylases central to methionine biosynthesis reveals druggable active site. Sci Rep, 9, 2019
8D1R	Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT520 分子名称: 1-{3-[(4-chlorophenyl)methoxy]phenyl}methanamine, GLYCEROL, N-acetyltransferase Eis 著者 Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2022-05-27 公開日 2022-09-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity. Eur.J.Med.Chem., 242, 2022
8D25	Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor SGT530 分子名称: 1-{2-[(3-chlorophenyl)methoxy]phenyl}-N-[(pyridin-4-yl)methyl]methanamine, GLYCEROL, N-acetyltransferase Eis 著者 Pang, A.H, Punetha, A, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2022-05-27 公開日 2022-09-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity. Eur.J.Med.Chem., 242, 2022
5TVJ	Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with CoA and inhibitor 2k*: 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium 分子名称: 1-(4-fluorophenyl)-2-[2-(4-methylphenyl)-2-oxoethyl]pyrrolo[1,2-a]pyrazin-2-ium, CHLORIDE ION, COENZYME A, ... 著者 Gajadeera, C.S, Garzan, A, Hou, C, Garneau-Tsodikova, S, Tsodikov, O.V. 登録日 2016-11-09 公開日 2017-03-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors. ACS Infect Dis, 3, 2017
5LI8	Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with ketoconazole 分子名称: 1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine, PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450 126 著者 Levy, C, Munro, A.W, Leys, D. 登録日 2016-07-14 公開日 2016-12-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1. J. Biol. Chem., 292, 2017
6CVF	Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine diphosphate 分子名称: ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Thompson, A.P, Bruning, J.B, Wegener, K.L, Polyak, S.W. 登録日 2018-03-28 公開日 2018-11-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes Acs Catalysis, 8(11), 2018
5LI6	Crystal structure of Mycobacterium tuberculosis CYP126A1 in complex with N-isopropyl-N-((3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)methyl)-2-(4-nitrophenyl)acetamide 分子名称: PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450 126, ~{N}-[[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl]-2-(4-nitrophenyl)-~{N}-propan-2-yl-ethanamide 著者 Levy, C, Munro, A.W, Leys, D. 登録日 2016-07-14 公開日 2016-12-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1. J. Biol. Chem., 292, 2017
6CZB	Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with uridine triphosphate (UTP) - promiscuous binding mode with disordered nucleoside 分子名称: ATP-dependent dethiobiotin synthetase BioD, MAGNESIUM ION, URIDINE 5'-TRIPHOSPHATE 著者 Thompson, A.P, Wegener, K.L, Bruning, J.B, Polyak, S.W. 登録日 2018-04-09 公開日 2018-11-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes Acs Catalysis, 8(11), 2018
6CVE	Crystal structure of Mycobacterium tuberculosis dethiobiotin Synthetase in complex with cytidine triphosphate and 7,8-diaminopelargonic acid 分子名称: 7-(CARBOXYAMINO)-8-AMINO-NONANOIC ACID, ATP-dependent dethiobiotin synthetase BioD, CITRATE ANION, ... 著者 Thompson, A.P, Bruning, J.B, Wegener, K.L, Polyak, S.W. 登録日 2018-03-28 公開日 2018-11-21 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes Acs Catalysis, 8(11), 2018
3MFE	Crystal Structure of Mycobacterium Tuberculosis Proteasome open-gate mutant with H0 movement 分子名称: Proteasome subunit alpha, Proteasome subunit beta 著者 Li, D, Li, H. 登録日 2010-04-02 公開日 2010-06-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for the assembly and gate closure mechanisms of the Mycobacterium tuberculosis 20S proteasome. Embo J., 2010

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