6JSI
 
 | | Co-purified Fatty Acid Synthase | | 分子名称: | Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta | | 著者 | Qiu, S.W, Liu, S. | | 登録日 | 2019-04-08 | | 公開日 | 2019-09-25 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | | 主引用文献 | Modulation of fatty acid synthase by ATR checkpoint kinase Rad3.
J Mol Cell Biol, 11, 2019
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7MHD
 | | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635 | | 分子名称: | Fatty acid synthase, N,N-diethyl-4-{2-[(2-fluorophenyl)methyl]-1,3-thiazol-4-yl}benzene-1-sulfonamide | | 著者 | Aleshin, A.E, Lambert, L, Liddington, R.C, Cosford, N. | | 登録日 | 2021-04-15 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635
To Be Published
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4W9N
 | | Enoyl-acyl carrier protein-reductase domain from human fatty acid synthase complexed with triclosan | | 分子名称: | CHLORIDE ION, Enoyl-[acyl-carrier-protein] reductase, IMIDAZOLE, ... | | 著者 | Sippel, K.H, Vyas, N.K, Sankaran, B, Quiocho, F.A. | | 登録日 | 2014-08-27 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Crystal structure of the human Fatty Acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition.
J.Biol.Chem., 289, 2014
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6U5T
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6U5U
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6U5V
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6U5W
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6BQC
 | | Cyclopropane fatty acid synthase from E. coli | | 分子名称: | (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE, CARBONATE ION, Cyclopropane-fatty-acyl-phospholipid synthase, ... | | 著者 | Hari, S.B, Grant, R.A, Sauer, R.T. | | 登録日 | 2017-11-27 | | 公開日 | 2018-07-04 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.073 Å) | | 主引用文献 | Structural and Functional Analysis of E. coli Cyclopropane Fatty Acid Synthase.
Structure, 26, 2018
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4XJV
 | | Crystal structure of human thioesterase 2 | | 分子名称: | CHLORIDE ION, S-acyl fatty acid synthase thioesterase, medium chain | | 著者 | Ritchie, M.K, Kridel, S.J, Lowther, W.T. | | 登録日 | 2015-01-09 | | 公開日 | 2015-12-16 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structure and Substrate Specificity of Human Thioesterase 2: INSIGHTS INTO THE MOLECULAR BASIS FOR THE MODULATION OF FATTY ACID SYNTHASE.
J.Biol.Chem., 291, 2016
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2BYZ
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2BZ3
 | | Structure of E.coli KAS I H298E mutant in complex with C12 fatty acid | | 分子名称: | 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, LAURIC ACID, ... | | 著者 | Olsen, J.G, von Wettstein-Knowles, P, Henriksen, A. | | 登録日 | 2005-08-10 | | 公開日 | 2006-02-01 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.
FEBS J., 273, 2006
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6FN6
 | | Modifying region (DH-ER-KR) of an insect fatty acid synthase (FAS) | | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, Fatty acid synthase 1, ... | | 著者 | Benning, F.M.C, Bukhari, H.S.T, Jakob, R.P, Maier, T. | | 登録日 | 2018-02-02 | | 公開日 | 2019-03-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Modifying region (DH-ER-KR) of an insect fatty acid synthase (FAS)
To Be Published
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7MHE
 | | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7957 | | 分子名称: | 1,2-ETHANEDIOL, 4-{4-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]benzene-1-sulfonyl}morpholine, Fatty acid synthase | | 著者 | Aleshin, A.E, Lambert, L, Liddington, R.C, Cosford, N. | | 登録日 | 2021-04-15 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635
To Be Published
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2IX4
 | | Arabidopsis thaliana mitochondrial beta-ketoacyl ACP synthase hexanoic acid complex | | 分子名称: | 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, HEXANOIC ACID, POTASSIUM ION | | 著者 | Christensen, C.E, Kragelund, B.B, von Wettstein-Knowles, P, Henriksen, A. | | 登録日 | 2006-07-06 | | 公開日 | 2007-02-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of the Human Beta-Ketoacyl [Acp] Synthase from the Mitochondrial Type II Fatty Acid Synthase.
Protein Sci., 16, 2007
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2IWZ
 | | Human mitochondrial beta-ketoacyl ACP synthase complexed with hexanoic acid | | 分子名称: | 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, AMMONIUM ION, HEXANOIC ACID | | 著者 | Christensen, C.E, Kragelund, B.B, von Wettstein-Knowles, P, Henriksen, A. | | 登録日 | 2006-07-05 | | 公開日 | 2007-02-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structure of the Human Beta-Ketoacyl [Acp] Synthase from the Mitochondrial Type II Fatty Acid Synthase.
Protein Sci., 16, 2007
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1MLA
 | | THE ESCHERICHIA COLI MALONYL-COA:ACYL CARRIER PROTEIN TRANSACYLASE AT 1.5-ANGSTROMS RESOLUTION. CRYSTAL STRUCTURE OF A FATTY ACID SYNTHASE COMPONENT | | 分子名称: | MALONYL-COENZYME A ACYL CARRIER PROTEIN TRANSACYLASE | | 著者 | Serre, L, Verbree, E.C, Dauter, Z, Stuitje, A.R, Derewenda, Z.S. | | 登録日 | 1995-01-25 | | 公開日 | 1996-03-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The Escherichia coli malonyl-CoA:acyl carrier protein transacylase at 1.5-A resolution. Crystal structure of a fatty acid synthase component.
J.Biol.Chem., 270, 1995
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3TJM
 | | Crystal Structure of the Human Fatty Acid Synthase Thioesterase Domain with an Activate Site-Specific Polyunsaturated Fatty Acyl Adduct | | 分子名称: | Fatty acid synthase, methyl (R)-(6Z,9Z,12Z)-octadeca-6,9,12-trien-1-ylphosphonofluoridate | | 著者 | Zhang, W, Zheng, F, Florante, A.Q. | | 登録日 | 2011-08-24 | | 公開日 | 2011-09-28 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid.
Proc.Natl.Acad.Sci.USA, 108, 2011
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2JFD
 | | Structure of the MAT domain of human FAS | | 分子名称: | FATTY ACID SYNTHASE | | 著者 | Bunkoczi, G, Kavanagh, K, Hozjan, V, Rojkova, A, Wu, X, Arrowsmith, C.H, Edwards, A, Sundstrom, M, Weigelt, J, Smith, S, Oppermann, U. | | 登録日 | 2007-01-31 | | 公開日 | 2007-02-13 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Structural basis for different specificities of acyltransferases associated with the human cytosolic and mitochondrial fatty acid synthases.
Chem. Biol., 16, 2009
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2BYX
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2BUI
 | | E. COLI BETA-KETOACYL (ACYL CARRIER PROTEIN) SYNTHASE I IN COMPLEX WITH OCTANOIC ACID, 120K | | 分子名称: | 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION, OCTANOIC ACID (CAPRYLIC ACID) | | 著者 | Olsen, J.G, Von Wettstein-Knowles, P, Henriksen, A. | | 登録日 | 2005-06-13 | | 公開日 | 2005-06-16 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases.
FEBS J., 273, 2006
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4CW4
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2IWY
 | | Human mitochondrial beta-ketoacyl ACP synthase | | 分子名称: | 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, AMMONIUM ION | | 著者 | Christensen, C.E, Kragelund, B.B, von Wettstein-Knowles, P, Henriksen, A. | | 登録日 | 2006-07-05 | | 公開日 | 2007-02-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Structure of the Human Beta-Ketoacyl [Acp] Synthase from the Mitochondrial Type II Fatty Acid Synthase.
Protein Sci., 16, 2007
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5BP2
 | | Dehydratase domain (DH) of a mycocerosic acid synthase-like (MAS-like) PKS, crystal form 1 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | | 著者 | Herbst, D.A, Jakob, P.R, Zaehringer, F, Maier, T. | | 登録日 | 2015-05-27 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases.
Nature, 531, 2016
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5BP3
 | | Dehydratase domain (DH) of a mycocerosic acid synthase-like (MAS-like) PKS, crystal form 2 | | 分子名称: | 1,2-ETHANEDIOL, Mycocerosic acid synthase-like polyketide synthase | | 著者 | Herbst, D.A, Jakob, P.R, Zaehringer, F, Maier, T. | | 登録日 | 2015-05-27 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases.
Nature, 531, 2016
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2KOP
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