PDB: 69 件ウェブページステータス検索Chemie searchBIRD

---

3SS3	Crystal structure of mouse Glutaminase C, ligand-free form 分子名称: CHLORIDE ION, Glutaminase C 著者 Ambrosio, A.L.B, Dias, S.M.G, Cerione, R.A. 登録日 2011-07-07 公開日 2012-01-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism. Proc.Natl.Acad.Sci.USA, 109, 2012
8IMB	Filament interface structure of GAC with phosphate 分子名称: Glutaminase kidney isoform, mitochondrial, PHOSPHATE ION 著者 Guo, C.J, Liu, J.L. 登録日 2023-03-06 公開日 2024-04-10 最終更新日 2024-04-17 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis for activation and filamentation of glutaminase. Cell Res., 34, 2024
8IMA	Filament structure of GAC with phosphate 分子名称: Glutaminase kidney isoform, mitochondrial, PHOSPHATE ION 著者 Guo, C.J, Liu, J.L. 登録日 2023-03-06 公開日 2024-04-10 最終更新日 2024-04-17 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis for activation and filamentation of glutaminase. Cell Res., 34, 2024
8JUB	Crystal structure of glutaminase C in complex with compound 27 分子名称: 3-[2-oxidanylidene-2-[[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]amino]ethyl]benzoic acid, Glutaminase kidney isoform, mitochondrial 著者 Wang, X, Hanyu, S, Tingting, D. 登録日 2023-06-26 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14, 2023
8JUE	Crystal structure of glutaminase C in complex with compound 11 分子名称: 2-(3-phenoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial 著者 Wang, X, Hanyu, S, Tingting, D. 登録日 2023-06-26 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14, 2023
8BSL	Human GLS in complex with compound 12 分子名称: Glutaminase kidney isoform, mitochondrial, ~{N}-[5-[[(3~{R})-1-(5-azanyl-1,3,4-thiadiazol-2-yl)pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]-2-phenyl-ethanamide 著者 Debreczeni, J.E. 登録日 2022-11-25 公開日 2023-01-18 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models. J Med Chem, 62, 2019
6UJG	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: Glutaminase kidney isoform, mitochondrial, N-{5-[(3S)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-03 公開日 2020-10-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00012 To Be Published
6UMD	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: 2-(pyridin-3-yl)-N-(5-{4-[(5-{[(pyridin-3-yl)acetyl]amino}-1,3,4-thiadiazol-2-yl)amino]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-09 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00012 To Be Published
6UME	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: 2-(pyridin-3-yl)-N-(5-{4-[(5-{[(pyridin-3-yl)acetyl]amino}-1,3,4-thiadiazol-2-yl)amino]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-09 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00012 To Be Published
6UMC	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: 2-phenyl-N-{5-[(3R)-3-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-09 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00012 To Be Published
6ULJ	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: 2-phenyl-N-{6-[4-({6-[(phenylacetyl)amino]pyridazin-3-yl}oxy)piperidin-1-yl]pyridazin-3-yl}acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-08 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00045 To Be Published
6UMF	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: Glutaminase kidney isoform, mitochondrial, N-(5-{[1-(5-amino-1,3,4-thiadiazol-2-yl)piperidin-4-yl]oxy}-1,3,4-thiadiazol-2-yl)-2-phenylacetamide 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-09 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00012 To Be Published
6UK6	Crystal structure of human GAC in complex with inhibitor UPGL00018 分子名称: 5-{4-[(5-amino-1,3,4-thiadiazol-2-yl)oxy]piperidin-1-yl}-1,3,4-thiadiazol-2-amine, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-04 公開日 2020-10-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00018 To Be Published
6UKB	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: Glutaminase kidney isoform, mitochondrial, N-[5-(4-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]oxy}piperidin-1-yl)-1,3,4-thiadiazol-2-yl]acetamide 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-04 公開日 2020-10-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00020 To Be Published
6ULA	Crystal structure of human GAC in complex with inhibitor UPGL00012 分子名称: 2-cyclopropyl-N-{5-[4-({5-[(cyclopropylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-07 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00030 To Be Published
6UJM	Crystal structure of human GAC in complex with inhibitor UPGL00013 分子名称: Glutaminase kidney isoform, mitochondrial, N-{5-[(3R)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide 著者 Huang, Q, Cerione, R.A. 登録日 2019-10-03 公開日 2020-10-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00013 To Be Published
6UL9	Crystal structure of human GAC in complex with inhibitor UPGL00023 分子名称: 2-phenyl-N-{5-[(1-{5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}azetidin-3-yl)oxy]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial 著者 Huang, Q.Q, Cerione, R.A. 登録日 2019-10-07 公開日 2020-10-14 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of human GAC in complex with inhibitor UPGL00012 To Be Published
3UO9	Crystal Structure of Human GAC in Complex with Glutamate and BPTES 分子名称: GLYCEROL, Glutaminase kidney isoform, mitochondrial, ... 著者 DeLaBarre, B, Gross, S, Cheng, F, Gao, Y, Jha, A, Jiang, F, Song, J.J, Wei, W, Hurov, J.B. 登録日 2011-11-16 公開日 2011-12-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry, 50, 2011
3UNW	Crystal Structure of Human GAC in Complex with Glutamate 分子名称: GLUTAMIC ACID, Glutaminase kidney isoform, mitochondrial 著者 DeLaBarre, B, Gross, S, Cheng, F, Gao, Y, Jha, A, Jiang, F, Song, J.J, Wie, W, Hurov, J. 登録日 2011-11-16 公開日 2011-12-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry, 50, 2011

<123