PDB: 282 件ウェブページステータス検索Chemie searchBIRD

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8IN9	The structure of the GfsA KSQ-AT didomain in complex with the GfsA ACP domain 分子名称: N-[2-(acetylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, Polyketide synthase 著者 Chisuga, T, Murakami, S, Miyanaga, A, Kudo, F, Eguchi, T. 登録日 2023-03-09 公開日 2023-05-31 最終更新日 2023-06-28 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structure-Based Analysis of Transient Interactions between Ketosynthase-like Decarboxylase and Acyl Carrier Protein in a Loading Module of Modular Polyketide Synthase. Acs Chem.Biol., 18, 2023
4ZDN	Streptomyces platensis isomigrastatin ketosynthase domain MgsF KS4 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AT-less polyketide synthase, CHLORIDE ION 著者 Chang, C, Li, H, Endres, M, Bingman, C.A, Yennamalli, R, Lohman, J.R, Ma, M, Shen, B, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) 登録日 2015-04-17 公開日 2015-05-13 最終更新日 2023-03-22 実験手法 X-RAY DIFFRACTION (2.509 Å) 主引用文献 Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases. Proc.Natl.Acad.Sci.USA, 112, 2015
4B7V	Structure of wild type Pseudomonas aeruginosa FabF (KASII) 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 2, POTASSIUM ION 著者 Lecker, L, Baum, B, Zoltner, M, Hunter, W.N. 登録日 2012-08-22 公開日 2013-09-04 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Structures of Pseudomonas Aeruginosa Beta-Keto-Acyl-(Acyl-Carrier-Protein) Synthase II (Fabf) and a C164Q Mutant Provide Templates for Antibacterial Drug Discovery and Identify a Buried Potassium Ion and a Ligand-Binding Site that is an Artefact of the Crystal Form Acta Crystallogr.,Sect.F, 71, 2015
7TUI	Structure of C. albicans FAS in an inhibited state 分子名称: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta 著者 Lou, J.W, Mazhab-Jafari, M.T. 登録日 2022-02-02 公開日 2023-02-15 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.66 Å) 主引用文献 Structure of C. albicans FAS in an inhibited state. Not published
6WC7	Acyl carrier protein (ACP) domain bound to dehydratase (DH) domain in fungal fatty acid synthase (FAS) 分子名称: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta 著者 Lou, J.W, Mazhab-Jafari, M.T. 登録日 2020-03-29 公開日 2020-06-03 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (5.8 Å) 主引用文献 Steric occlusion regulates proximal interactions of acyl carrier protein domain in fungal fatty acid synthase. Commun Biol, 3, 2020
7UWR	KSQ+AT from first module of the pikromycin synthase 分子名称: Narbonolide/10-deoxymethynolide synthase PikA1, modules 1 and 2 著者 Keatinge-Clay, A.T, Dickinson, M.S, Miyazawa, T, McCool, R.S. 登録日 2022-05-03 公開日 2022-06-08 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.61 Å) 主引用文献 Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry. Structure, 30, 2022
4CW4	Crystal structure of the noncanonical ketosynthase FabY from P. aeruginosa 分子名称: BETA-KETOACYL SYNTHASE, CHLORIDE ION, SULFATE ION 著者 Bukhari, H.S.T, Jakob, R.P, Maier, T. 登録日 2014-04-01 公開日 2014-12-17 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.349 Å) 主引用文献 Evolutionary Origins of the Multienzyme Architecture of Giant Fungal Fatty Acid Synthase. Structure, 22, 2014
1H4F	E. COLI BETA-KETOACYL [ACYL CARRIER PROTEIN] SYNTHASE I K328R 分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE I, AMMONIUM ION 著者 Olsen, J.G, von Wettstein-Knowles, P, Mcguire, K.A, Henriksen, A. 登録日 2003-02-26 公開日 2004-03-29 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. FEBS J., 273, 2006
4Z37	Structure of the ketosynthase of module 2 of C0ZGQ5 (trans-AT PKS) from Brevibacillus brevis 分子名称: Putative mixed polyketide synthase/non-ribosomal peptide synthetase 著者 Martin, S.F, Jakob, R.P, Herbst, D.A, Maier, T. 登録日 2015-03-31 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.998 Å) 主引用文献 The structural organization of trans-AT polyketide synthases: ketoacyl synthase and trans-acting enoyl reductase To Be Published
7S6C	CryoEM structure of modular PKS holo-Lsd14 stalled at the condensation step and bound to antibody fragment 1B2, composite structure 分子名称: 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 4'-PHOSPHOPANTETHEINE, 6-deoxyerythronolide-B synthase EryA2, ... 著者 Bagde, S.R, Kim, C.-Y, Fromme, J.C. 登録日 2021-09-13 公開日 2021-11-03 最終更新日 2021-11-17 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374, 2021
7S6D	CryoEM structure of modular PKS holo-Lsd14 bound to antibody fragment 1B2, composite structure 分子名称: 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, ... 著者 Bagde, S.R, Kim, C.-Y, Fromme, J.C. 登録日 2021-09-13 公開日 2021-11-03 最終更新日 2021-11-17 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374, 2021
7S6B	Crystal structure of modular polyketide synthase apo-Lsd14 from the Lasalocid biosynthesis pathway, trapped in the transacylation step 分子名称: Polyketide synthase 著者 Bagde, S.R, Mathews, I.I, Kim, C.-Y. 登録日 2021-09-13 公開日 2021-11-03 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Modular polyketide synthase contains two reaction chambers that operate asynchronously. Science, 374, 2021
5BP1	Condensing di-domain (KS-AT) of a mycocerosic acid synthase-like (MAS-like) PKS 分子名称: Mycocerosic acid synthase 著者 Jakob, R.P, Herbst, D.A, Zaehringer, F, Maier, T. 登録日 2015-05-27 公開日 2016-03-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.203 Å) 主引用文献 Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases. Nature, 531, 2016
3G11	Structure of E. coli FabF(C163Q) in complex with dihydrophenyl platensimycin 分子名称: 3-({3-[(1S,4S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxo-4-phenyldecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2 著者 Soisson, S.M, Parthasarathy, G. 登録日 2009-01-29 公開日 2009-03-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Synthesis and biological evaluation of platensimycin analogs. Bioorg.Med.Chem.Lett., 19, 2009
4DDO	Crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase ii from burkholderia vietnamiensis 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, SODIUM ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-01-19 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013
3G0Y	Structure of E. coli FabF(C163Q) in complex with dihydroplatensimycin 分子名称: 3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxodecahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2 著者 Soisson, S.M, Parthasarathy, G. 登録日 2009-01-29 公開日 2009-03-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Synthesis and biological evaluation of platensimycin analogs. Bioorg.Med.Chem.Lett., 19, 2009
7VEF	The structure of GfsA KSQ-AT didomain in complex with a malonate substrate analog 分子名称: GLYCEROL, N-(2-acetamidoethyl)-2-nitro-ethanamide, Polyketide synthase 著者 Chisuga, T, Miyanaga, A, Nagai, A, Kudo, F, Eguchi, T. 登録日 2021-09-08 公開日 2022-01-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases. Acs Chem.Biol., 17, 2022
7VEE	The ligand-free structure of GfsA KSQ-AT didomain 分子名称: GLYCEROL, Polyketide synthase 著者 Chisuga, T, Miyanaga, A, Nagai, A, Kudo, F, Eguchi, T. 登録日 2021-09-08 公開日 2022-01-12 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases. Acs Chem.Biol., 17, 2022
3LRF	Crystal structure of beta-ketoacyl synthase from brucella melitensis 分子名称: Beta-ketoacyl synthase, SODIUM ION 著者 Abendroth, J, Edwards, T, Staker, B, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2010-02-11 公開日 2010-03-31 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural characterization of beta-ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites. Proteins, 88, 2020
4NA2	Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to its natural intermediate 分子名称: Polyketide synthase PksJ 著者 Gay, D.C, Gay, G.R, Keatinge-Clay, A.T. 登録日 2013-10-21 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure, 22, 2014
4MZ0	Structure of a ketosynthase-acyltransferase di-domain from module CurL of the curacin A polyketide synthase 分子名称: CALCIUM ION, CurL 著者 Whicher, J.R, Smaga, S.S, Smith, J.L. 登録日 2013-09-28 公開日 2014-01-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis. Chem.Biol., 20, 2013
4NA1	Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase 分子名称: Polyketide synthase PksJ, SULFATE ION 著者 Gay, D.C, Gay, G.R, Keatinge-Clay, A.T. 登録日 2013-10-21 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure, 22, 2014
4NA3	Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to a hexanoyl substrate mimic 分子名称: Polyketide synthase PksJ, SULFATE ION 著者 Gay, D.C, Gay, G.R, Keatinge-Clay, A.T. 登録日 2013-10-21 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase. Structure, 22, 2014
2GFX	Structure of E. coli FabF(C163Q) in complex with Platensimycin 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, PLATENSIMYCIN 著者 Soisson, S.M, Parthasarathy, G. 登録日 2006-03-23 公開日 2006-05-23 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006
2GFW	Structure of wild type E. coli FabF (KASII) 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2 著者 Soisson, S.M, Parthasarathy, G. 登録日 2006-03-23 公開日 2006-05-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature, 441, 2006

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