5AJ2
| Cryo electron tomography of the Naip5-Nlrc4 inflammasome | 分子名称: | NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 4 | 著者 | Diebolder, C.A, Halff, E.F, Koster, A.J, Huizinga, E.G, Koning, R.I. | 登録日 | 2015-02-20 | 公開日 | 2015-11-11 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (40 Å) | 主引用文献 | Cryoelectron Tomography of the Naip5/Nlrc4 Inflammasome: Implications for Nlr Activation. Structure, 23, 2015
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6B5B
| Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome | 分子名称: | Baculoviral IAP repeat-containing protein 1e, Flagellin, NLR family CARD domain-containing protein 4 | 著者 | Tenthorey, J.L, Haloupek, N, Lopez-Blanco, J.R, Grob, P, Adamson, E, Hartenian, E, Lind, N.A, Bourgeois, N.M, Chacon, P, Nogales, E, Vance, R.E. | 登録日 | 2017-09-29 | 公開日 | 2017-11-15 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion. Science, 358, 2017
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1Z6T
| Structure of the apoptotic protease-activating factor 1 bound to ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Apoptotic protease activating factor 1 | 著者 | Riedl, S.J, Li, W, Chao, Y, Schwarzenbacher, R, Shi, Y. | 登録日 | 2005-03-23 | 公開日 | 2005-04-19 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Structure of the apoptotic protease-activating factor 1 bound to ADP Nature, 434, 2005
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8FW2
| Cryo-EM structure of full-length human NLRC4 inflammasome with C11 symmetry | 分子名称: | NLR family CARD domain-containing protein 4 | 著者 | Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S. | 登録日 | 2023-01-20 | 公開日 | 2024-01-03 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing. Nat.Struct.Mol.Biol., 31, 2024
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8FVU
| Cryo-EM structure of human Needle/NAIP/NLRC4 (R288A) | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Baculoviral IAP repeat-containing protein 1, Lethal factor,Type III secretion system protein, ... | 著者 | Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S. | 登録日 | 2023-01-19 | 公開日 | 2024-01-03 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing. Nat.Struct.Mol.Biol., 31, 2024
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8FW9
| Cryo-EM structure of full-length human NLRC4 inflammasome with C12 symmetry | 分子名称: | NLR family CARD domain-containing protein 4 | 著者 | Matico, R.E, Yu, X, Miller, R, Somani, S, Ricketts, M.D, Kumar, N, Steele, R.A, Medley, Q, Berger, S, Faustin, B, Sharma, S. | 登録日 | 2023-01-20 | 公開日 | 2024-01-03 | 最終更新日 | 2024-01-31 | 実験手法 | ELECTRON MICROSCOPY (4.46 Å) | 主引用文献 | Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing. Nat.Struct.Mol.Biol., 31, 2024
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8JNS
| cryo-EM structure of a CED-4 hexamer | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 4, MAGNESIUM ION | 著者 | Li, Y, Shi, Y. | 登録日 | 2023-06-06 | 公開日 | 2023-06-28 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural insights into CED-3 activation. Life Sci Alliance, 6, 2023
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8JO0
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8JOL
| cryo-EM structure of the CED-4/CED-3 holoenzyme | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 3, Cell death protein 4, ... | 著者 | Li, Y, Tian, L, Zhang, Y, Shi, Y. | 登録日 | 2023-06-07 | 公開日 | 2023-06-28 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural insights into CED-3 activation. Life Sci Alliance, 6, 2023
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2KN6
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3T6P
| IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization | 分子名称: | Baculoviral IAP repeat-containing protein 2, ZINC ION | 著者 | Dueber, E.C, Schoeffler, A.J, Lingel, A, Elliott, M, Fedorova, A.V, Giannetti, A.M, Zobel, K, Maurer, B, Varfolomeev, E, Wu, P, Wallweber, H, Hymowitz, S, Deshayes, K, Vucic, D, Fairbrother, W.J. | 登録日 | 2011-07-28 | 公開日 | 2011-11-02 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | 主引用文献 | Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination. Science, 334, 2011
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5GPQ
| Crystal Structure of zebrafish ASC CARD Domain | 分子名称: | CITRIC ACID, Maltose-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Jin, T, Li, Y. | 登録日 | 2016-08-04 | 公開日 | 2017-08-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Functional and structural characterization of zebrafish ASC. FEBS J., 285, 2018
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3LQQ
| Structure of the CED-4 Apoptosome | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 4, MAGNESIUM ION | 著者 | Qi, S, Pang, Y, Shi, Y, Yan, N, Liu, Q. | 登録日 | 2010-02-09 | 公開日 | 2010-04-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.534 Å) | 主引用文献 | Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell(Cambridge,Mass.), 141, 2010
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3LQR
| Structure of CED-4:CED-3 complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell death protein 4, MAGNESIUM ION | 著者 | Qi, S, Pang, Y, Shi, Y, Yan, N. | 登録日 | 2010-02-09 | 公開日 | 2010-04-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.896 Å) | 主引用文献 | Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell(Cambridge,Mass.), 141, 2010
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4M9S
| crystal structure of CED-4 bound CED-3 fragment | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ... | 著者 | Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G. | 登録日 | 2013-08-15 | 公開日 | 2013-10-23 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (3.207 Å) | 主引用文献 | Mechanistic insights into CED-4-mediated activation of CED-3. Genes Dev., 27, 2013
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4M9Y
| Crystal structure of CED-4 bound CED-3 fragment | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ... | 著者 | Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G. | 登録日 | 2013-08-15 | 公開日 | 2013-10-23 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Mechanistic insights into CED-4-mediated activation of CED-3. Genes Dev., 27, 2013
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4KXF
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4M9Z
| Crystal structure of CED-4 bound CED-3 fragment | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ... | 著者 | Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G. | 登録日 | 2013-08-15 | 公開日 | 2013-10-23 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (3.405 Å) | 主引用文献 | Mechanistic insights into CED-4-mediated activation of CED-3. Genes Dev., 27, 2013
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4IRL
| X-ray structure of the CARD domain of zebrafish GBP-NLRP1 like protein | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Jin, T, Huang, M, Smith, P, Xiao, T. | 登録日 | 2013-01-15 | 公開日 | 2013-08-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein. Acta Crystallogr.,Sect.F, 69, 2013
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4M9X
| Crystal structure of CED-4 bound CED-3 fragment | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ... | 著者 | Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G. | 登録日 | 2013-08-15 | 公開日 | 2013-10-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.344 Å) | 主引用文献 | Mechanistic insights into CED-4-mediated activation of CED-3. Genes Dev., 27, 2013
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4IFP
| X-ray Crystal Structure of Human NLRP1 CARD Domain | 分子名称: | MALONATE ION, Maltose-binding periplasmic protein,NACHT, LRR and PYD domains-containing protein 1, ... | 著者 | Jin, T, Curry, J, Smith, P, Jiang, J, Xiao, T. | 登録日 | 2012-12-14 | 公開日 | 2013-04-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9948 Å) | 主引用文献 | Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1. Proteins, 81, 2013
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4IKM
| X-ray structure of CARD8 CARD domain | 分子名称: | 1,2-ETHANEDIOL, IODIDE ION, Maltose-binding periplasmic protein, ... | 著者 | Jin, T, Huang, M, Smith, P, Jiang, J, Xiao, T. | 登録日 | 2012-12-26 | 公開日 | 2013-05-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4606 Å) | 主引用文献 | The structure of the CARD8 caspase-recruitment domain suggests its association with the FIIND domain and procaspases through adjacent surfaces. Acta Crystallogr.,Sect.F, 69, 2013
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6KI0
| Crystal Structure of Human ASC-CARD | 分子名称: | Maltose/maltodextrin-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Xu, Z.H, Jin, T.C. | 登録日 | 2019-07-16 | 公開日 | 2020-07-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome. Cell Death Dis, 12, 2021
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6MKS
| Cryo-EM structure of NLRC4-CARD filament | 分子名称: | Chimera protein of NLR family CARD domain-containing protein 4 and EGFP | 著者 | Zheng, W, Matyszewski, M, Sohn, J, Egelman, E.H. | 登録日 | 2018-09-26 | 公開日 | 2018-11-07 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of the NLRC4CARDfilament provides insights into how symmetric and asymmetric supramolecular structures drive inflammasome assembly. J. Biol. Chem., 293, 2018
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5JUY
| Active human apoptosome with procaspase-9 | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Apoptotic protease-activating factor 1, Caspase-9, ... | 著者 | Cheng, T.C, Hong, C, Akey, I.V, Yuan, S, Akey, C.W. | 登録日 | 2016-05-10 | 公開日 | 2016-10-19 | 最終更新日 | 2019-12-25 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | A near atomic structure of the active human apoptosome. Elife, 5, 2016
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