8R04
| Structure of Staphylococcus aureus ClpP Bound to the Covalent Active Site Inhibitor Cystargolide A | 分子名称: | ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) | 著者 | Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. | 登録日 | 2023-10-30 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
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8R05
| Photorhabdus lamondii ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.5 A resolution | 分子名称: | ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound) | 著者 | Illigmann, A, Vielberg, M.-T, Lakemeyer, M, Wolf, F, Staudt, N, Dema, T, Stange, P, Liebhart, E, Kuttenlochner, W, Kulik, A, Malik, I, Grond, S, Sieber, S.A, Groll, M, Kaysser, L, Broetz-Oesterhelt, H. | 登録日 | 2023-10-30 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A. Angew.Chem.Int.Ed.Engl., 63, 2024
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5E0S
| crystal structure of the active form of the proteolytic complex clpP1 and clpP2 | 分子名称: | ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2 | 著者 | LI, M, Wlodawer, A, Maurizi, M. | 登録日 | 2015-09-29 | 公開日 | 2016-02-17 | 最終更新日 | 2016-04-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis. J.Biol.Chem., 291, 2016
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7MK5
| Crystal structure of Escherichia coli ClpP covalently inhibited by clipibicyclene | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-[(1E)-3-{[(2E,4E,6E,8S)-8-hydroxy-4-methyldeca-2,4,6-trienoyl]amino}-3-oxoprop-1-en-1-yl]azete-1(2H)-carboxylic acid, ACETATE ION, ... | 著者 | Culp, E.J, Sychantha, D, Hobson, C, Pawlowski, A.J, Prehna, G, Wright, G.D. | 登録日 | 2021-04-21 | 公開日 | 2022-02-02 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | ClpP inhibitors are produced by a widespread family of bacterial gene clusters. Nat Microbiol, 7, 2022
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2C8T
| The 3.0 A Resolution Structure of Caseinolytic Clp Protease 1 from Mycobacterium tuberculosis | 分子名称: | ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 | 著者 | Ingvarsson, H, Hogbom, M, Jones, T.A, Unge, T. | 登録日 | 2005-12-07 | 公開日 | 2007-02-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Insights Into the Inter-Ring Plasticity of Caseinolytic Proteases from the X-Ray Structure of Mycobacterium Tuberculosis Clpp1. Acta Crystallogr.,Sect.D, 63, 2007
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5DZK
| Crystal structure of the active form of the proteolytic complex clpP1 and clpP2 | 分子名称: | ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2, BEZ-LEU-LEU | 著者 | LI, M, Wlodawer, A, Maurizi, M. | 登録日 | 2015-09-25 | 公開日 | 2016-02-17 | 最終更新日 | 2016-04-13 | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | 主引用文献 | Structure and Functional Properties of the Active Form of the Proteolytic Complex, ClpP1P2, from Mycobacterium tuberculosis. J.Biol.Chem., 291, 2016
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8QYF
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5DKP
| Crystal Structure of N. meningitidis ClpP in complex with agonist ADEP A54556. | 分子名称: | ATP-dependent Clp protease proteolytic subunit, POTASSIUM ION, SODIUM ION, ... | 著者 | Goodreid, J.D, Janetzko, J, Santa Maria Jr, J.P, Wong, K, Leung, E, Eger, B.T, Bryson, S, Pai, E.F, Gray-Owen, S.D, Walker, S, Houry, W.A, Batey, R.A. | 登録日 | 2015-09-03 | 公開日 | 2016-01-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.381 Å) | 主引用文献 | Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity. J.Med.Chem., 59, 2016
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5DL1
| ClpP from Staphylococcus aureus in complex with AV145 | 分子名称: | 1-(propan-2-yl)-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, ATP-dependent Clp protease proteolytic subunit | 著者 | Vielberg, M.-T, Groll, M. | 登録日 | 2015-09-04 | 公開日 | 2015-11-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association. Angew.Chem.Int.Ed.Engl., 54, 2015
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2ZL3
| Crystal structure of H.pylori ClpP S99A | 分子名称: | ATP-dependent Clp protease proteolytic subunit | 著者 | Kim, D.Y, Kim, K.K. | 登録日 | 2008-04-02 | 公開日 | 2008-04-22 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | The structural basis for the activation and peptide recognition of bacterial ClpP J.Mol.Biol., 379, 2008
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2DEO
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4GM2
| The crystal structure of a peptidase from plasmodium falciparum | 分子名称: | ATP-dependent Clp protease proteolytic subunit | 著者 | El Bakkouri, M, Jung, P, Wernimont, A.K, Calmettes, C, Hui, R, Houry, W.A, Structural Genomics Consortium (SGC) | 登録日 | 2012-08-15 | 公開日 | 2012-12-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Insights into the Inactive Subunit of the Apicoplast-localized Caseinolytic Protease Complex of Plasmodium falciparum. J.Biol.Chem., 288, 2013
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7DFT
| Crystal structure of Xanthomonas oryzae ClpP | 分子名称: | ATP-dependent Clp protease proteolytic subunit, CHLORIDE ION | 著者 | Yang, C.-G, Yang, T. | 登録日 | 2020-11-09 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections. J.Agric.Food Chem., 69, 2021
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7DFU
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2ZL4
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7EKO
| CrClpP-S1 | 分子名称: | ATP-dependent Clp protease ATP-binding subunit CLPT4, chloroplastic, ATP-dependent Clp protease proteolytic subunit | 著者 | Wang, N, Wang, Y.F, Cong, Y, Liu, C.M. | 登録日 | 2021-04-06 | 公開日 | 2021-10-20 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | The cryo-EM structure of the chloroplast ClpP complex. Nat.Plants, 7, 2021
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4HNK
| Crystal structure of an Enzyme | 分子名称: | ATP-dependent Clp protease proteolytic subunit, GLYCEROL | 著者 | El Bakkouri, M, Calmettes, C, Wernimont, A.K, Houry, W.A, Hui, R, Structural Genomics Consortium (SGC) | 登録日 | 2012-10-19 | 公開日 | 2012-12-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural Insights into the Inactive Subunit of the Apicoplast-localized Caseinolytic Protease Complex of Plasmodium falciparum. J.Biol.Chem., 288, 2013
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4EMP
| Crystal structure of the mutant of ClpP E137A from Staphylococcus aureus | 分子名称: | ATP-dependent Clp protease proteolytic subunit | 著者 | Ye, F, Zhang, J, Liu, H, Luo, C, Yang, C.-G. | 登録日 | 2012-04-12 | 公開日 | 2013-04-17 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Helix unfolding/refolding characterizes the functional dynamics of Staphylococcus aureus Clp protease J.Biol.Chem., 288, 2013
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2ZL2
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6IW7
| structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease | 分子名称: | (2S)-2-benzamido-4-methyl-pentanoic acid, 4-[(4-fluoro-2-methyl-3H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline, ATP-dependent Clp protease proteolytic subunit 1, ... | 著者 | Bao, R, Luo, Y.F, Zhu, Y.B, Yang, Y, Zhou, Y.Z. | 登録日 | 2018-12-04 | 公開日 | 2020-01-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.692121 Å) | 主引用文献 | structural insights into Mycobacterium tuberculosis ClpP1P2 inhibition by Cediranib: implications for developing antimicrobial agents targeting Clp protease To Be Published
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6W9T
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6X60
| ClpP2 from Chlamydia trachomatis with resolved handle loop | 分子名称: | ATP-dependent Clp protease proteolytic subunit 2 | 著者 | Azadmanesh, J, Struble, L.R, Seleem, M.A, Ouellette, S, Conda-Sheridan, M, Borgstahl, G.E.O. | 登録日 | 2020-05-27 | 公開日 | 2020-06-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | ClpP2 from Chlamydia trachomatis with resolved handle loop To Be Published
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6L40
| Discovery of novel peptidomimetic boronate ClpP inhibitors with noncanonical enzyme mechanism as potent virulence blockers in vitro and in vivo | 分子名称: | ATP-dependent Clp protease proteolytic subunit, [(1S)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazin-2-ylcarbonylamino)propanoyl]amino]butyl]boronic acid | 著者 | Luo, Y.F, Bao, R, Ju, Y, He, L.H. | 登録日 | 2019-10-15 | 公開日 | 2020-07-08 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.209 Å) | 主引用文献 | Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockersin Vitroandin Vivo. J.Med.Chem., 63, 2020
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8XOP
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6L3X
| Discovery of novel peptidomimetic boronate ClpP inhibitors with noncanonical enzyme mechanism as potent virulence blockers in vitro and in vivo | 分子名称: | ATP-dependent Clp protease proteolytic subunit, [(1~{R})-1-[[(2~{S})-2-[[2,5-bis(chloranyl)phenyl]carbonylamino]-3-(1~{H}-indol-3-yl)propanoyl]amino]-3-methyl-butyl]boronic acid | 著者 | Luo, Y.F, Bao, R, Ju, Y, He, L.H. | 登録日 | 2019-10-15 | 公開日 | 2020-08-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.3054 Å) | 主引用文献 | Discovery of Novel Peptidomimetic Boronate ClpP Inhibitors with Noncanonical Enzyme Mechanism as Potent Virulence Blockersin Vitroandin Vivo. J.Med.Chem., 63, 2020
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