7MK5
Crystal structure of Escherichia coli ClpP covalently inhibited by clipibicyclene
Summary for 7MK5
| Entry DOI | 10.2210/pdb7mk5/pdb |
| Descriptor | ATP-dependent Clp protease proteolytic subunit, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... (5 entities in total) |
| Functional Keywords | inhibitor, complex, protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Escherichia coli K-12 |
| Total number of polymer chains | 28 |
| Total formula weight | 620629.89 |
| Authors | Culp, E.J.,Sychantha, D.,Hobson, C.,Pawlowski, A.J.,Prehna, G.,Wright, G.D. (deposition date: 2021-04-21, release date: 2022-02-02, Last modification date: 2024-04-03) |
| Primary citation | Culp, E.J.,Sychantha, D.,Hobson, C.,Pawlowski, A.C.,Prehna, G.,Wright, G.D. ClpP inhibitors are produced by a widespread family of bacterial gene clusters. Nat Microbiol, 7:451-462, 2022 Cited by PubMed: 35246663DOI: 10.1038/s41564-022-01073-4 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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