PDB: 226 件ウェブページステータス検索Chemie searchBIRD

---

3BZ7	Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II 分子名称: (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Allingham, J.S, Rayment, I. 登録日 2008-01-17 公開日 2008-02-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design. Org.Biomol.Chem., 6, 2008
5N69	Cardiac muscle myosin S1 fragment in the pre-powerstroke state co-crystallized with the activator Omecamtiv Mecarbil 分子名称: 3,3',3''-phosphanetriyltripropanoic acid, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... 著者 Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A. 登録日 2017-02-14 公開日 2017-08-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil. Nat Commun, 8, 2017
4DB1	Cardiac human myosin S1dC, beta isoform complexed with Mn-AMPPNP 分子名称: MANGANESE (II) ION, Myosin-7, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Klenchin, V.A, Deacon, J.C, Combs, A.C, Leinwand, L.A, Rayment, I. 登録日 2012-01-13 公開日 2012-01-25 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Cardiac human myosin S1dC, beta isoform complexed with Mn-AMPPNP To be Published
2MYS	MYOSIN SUBFRAGMENT-1, ALPHA CARBON COORDINATES ONLY FOR THE TWO LIGHT CHAINS 分子名称: MAGNESIUM ION, MYOSIN, SULFATE ION 著者 Rayment, I, Holden, H.M. 登録日 1996-06-27 公開日 1997-01-11 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Three-dimensional structure of myosin subfragment-1: a molecular motor. Science, 261, 1993
7MF3	Structure of the autoinhibited state of smooth muscle myosin-2 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin light polypeptide 6, ... 著者 Heissler, S.M, Arora, A.S, Billington, N, Sellers, J.R, Chinthalapudi, K. 登録日 2021-04-08 公開日 2022-01-05 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM structure of the autoinhibited state of myosin-2. Sci Adv, 7, 2021
5N6A	Cardiac muscle myosin motor domain in the pre-powerstroke state 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A. 登録日 2017-02-14 公開日 2017-08-09 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil. Nat Commun, 8, 2017
2OS8	Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor 分子名称: CALCIUM ION, MAGNESIUM ION, Myosin essential light chain, ... 著者 Yang, Y, Gourinath, S, Cohen, C, Brown, J.H. 登録日 2007-02-05 公開日 2007-05-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.27 Å) 主引用文献 Rigor-like Structures from Muscle Myosins Reveal Key Mechanical Elements in the Transduction Pathways of This Allosteric Motor. Structure, 15, 2007
2OTG	Rigor-like structures of muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, MAGNESIUM ION, ... 著者 Yang, Y, Gourinath, S, Kovacs, M, Nyitray, L, Reutzel, R, Himmel, D.M, O'Neall-Hennessey, E, Reshetnikova, L, Szent-Gyorgyi, A.G, Brown, J.H, Cohen, C. 登録日 2007-02-08 公開日 2007-05-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 Rigor-like Structures from Muscle Myosins Reveal Key Mechanical Elements in the Transduction Pathways of This Allosteric Motor. Structure, 15, 2007
2AKA	Structure of the nucleotide-free myosin II motor domain from Dictyostelium discoideum fused to the GTPase domain of dynamin 1 from Rattus norvegicus 分子名称: Dynamin-1, LINKER, myosin II heavy chain 著者 Reubold, T.F, Eschenburg, S, Becker, A, Leonard, M, Schmid, S.L, Vallee, R.B, Kull, F.J, Manstein, D.J. 登録日 2005-08-03 公開日 2005-08-23 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the GTPase domain of rat dynamin 1. Proc.Natl.Acad.Sci.Usa, 102, 2005
7QIO	Homology model of myosin neck domain in skeletal sarcomere 分子名称: Myosin light chain 1/3, skeletal muscle isoform, Myosin regulatory light chain 2, ... 著者 Wang, Z, Grange, M, Pospich, S, Wagner, T, Kho, A.L, Gautel, M, Raunser, S. 登録日 2021-12-15 公開日 2022-02-16 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (9 Å) 主引用文献 Structures from intact myofibrils reveal mechanism of thin filament regulation through nebulin. Science, 375, 2022
3I5F	Crystal structure of squid MG.ADP myosin S1 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin catalytic light chain LC-1, ... 著者 Yang, Y, Gourinath, S, Kovacs, M, Nyitray, L, Reutzel, R, Himmel, D.M, O'Neall-Hennessey, E, Reshetnikova, L, Szent-Gyorgyi, A.G, Brown, J.H, Cohen, C. 登録日 2009-07-05 公開日 2009-08-04 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor. Structure, 15, 2007
2BKI	Myosin VI nucleotide-free (MDinsert2-IQ) crystal structure 分子名称: CALCIUM ION, CALMODULIN, SULFATE ION, ... 著者 Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A. 登録日 2005-02-16 公開日 2005-06-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal Nature, 435, 2005
3I5I	The crystal structure of squid myosin S1 in the presence of SO4 2- 分子名称: CALCIUM ION, Myosin catalytic light chain LC-1, mantle muscle, ... 著者 Yang, Y, Gourinath, S, Kovacs, M, Nyitray, L, Reutzel, R, Himmel, D.M, O'Neall-Hennessey, E, Reshetnikova, L, Szent-Gyorgyi, A.G, Brown, J.H, Cohen, C. 登録日 2009-07-05 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor. Structure, 15, 2007
2BKH	Myosin VI nucleotide-free (MDInsert2) crystal structure 分子名称: CALCIUM ION, CALMODULIN, GLYCEROL, ... 著者 Menetrey, J, Bahloul, A, Yengo, C, Wells, A, Morris, C, Sweeney, H.L, Houdusse, A. 登録日 2005-02-16 公開日 2005-06-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The Structure of the Myosin Vi Motor Reveals the Mechanism of Directionality Reversal Nature, 435, 2005
3I5H	The crystal structure of rigor like squid myosin S1 in the absence of nucleotide 分子名称: CALCIUM ION, Myosin catalytic light chain LC-1, mantle muscle, ... 著者 Yang, Y, Gourinath, S, Kovacs, M, Nyitray, L, Reutzel, R, Himmel, D.M, O'Neall-Hennessey, E, Reshetnikova, L, Szent-Gyorgyi, A.G, Brown, J.H, Cohen, C. 登録日 2009-07-05 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor. Structure, 15, 2007
3I5G	Crystal structure of rigor-like squid myosin S1 分子名称: CALCIUM ION, MALONATE ION, Myosin catalytic light chain LC-1, ... 著者 Yang, Y, Gourinath, S, Kovacs, M, Nyitray, L, Reutzel, R, Himmel, D.M, O'Neall-Hennessey, E, Reshetnikova, L, Szent-Gyorgyi, A.G, Brown, J.H, Cohen, C. 登録日 2009-07-05 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor. Structure, 15, 2007
2DFS	3-D structure of Myosin-V inhibited state 分子名称: Calmodulin, Myosin-5A 著者 Liu, J, Taylor, D.W, Krementsova, E.B, Trybus, K.M, Taylor, K.A. 登録日 2006-03-03 公開日 2006-04-25 最終更新日 2024-03-13 実験手法 ELECTRON CRYSTALLOGRAPHY (24 Å) 主引用文献 Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography Nature, 442, 2006
2EC6	Placopecten Striated Muscle Myosin II 分子名称: CALCIUM ION, Myosin essential light chain, Myosin heavy chain, ... 著者 Yang, Y, Brown, J, Samudrala, G, Reutzel, R, Szent-Gyorgyi, A. 登録日 2007-02-10 公開日 2008-02-26 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Rigor-like structures from muscle myosins reveal key mechanical elements in the transduction pathways of this allosteric motor. Structure, 15, 2007
3J04	EM structure of the heavy meromyosin subfragment of Chick smooth muscle Myosin with regulatory light chain in phosphorylated state 分子名称: Myosin light polypeptide 6, Myosin regulatory light chain 2, smooth muscle major isoform, ... 著者 Baumann, B.A.J, Taylor, D, Huang, Z, Tama, F, Fagnant, P.M, Trybus, K, Taylor, K. 登録日 2011-02-18 公開日 2011-11-16 最終更新日 2024-02-21 実験手法 ELECTRON MICROSCOPY (20 Å) 主引用文献 Phosphorylated smooth muscle heavy meromyosin shows an open conformation linked to activation. J.Mol.Biol., 415, 2012
2Y8I	Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN-2 HEAVY CHAIN 著者 Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. 登録日 2011-02-07 公開日 2011-07-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.132 Å) 主引用文献 Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V. J.Biol.Chem., 286, 2011
8CDM	Plasmodium falciparum Myosin A full-length, post-rigor state complexed to the inhibitor KNX-002 分子名称: 1,2-ETHANEDIOL, 1-(4-methoxyphenyl)-~{N}-[(3-thiophen-2-yl-1~{H}-pyrazol-4-yl)methyl]cyclopropan-1-amine, Myosin A tail domain interacting protein, ... 著者 Moussaoui, D, Robblee, J.P, Robert-Paganin, J, Auguin, D, Fisher, F, Fagnant, P.M, MacFarlane, J.E, Mueller-Dieckmann, C, Baum, J, Trybus, K.M, Houdusse, A. 登録日 2023-01-31 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Plasmodium falciparum Myosin A full-length, post-rigor state complexed to the inhibitor KNX-002 To Be Published
2XO8	Crystal Structure of Myosin-2 in Complex with Tribromodichloropseudilin 分子名称: 2,4-DICHLORO-6-(3,4,5-TRIBROMO-1H-PYRROL-2-YL)PHENOL, ADP METAVANADATE, MAGNESIUM ION, ... 著者 Preller, M, Chinthalapudi, K, Martin, R, Knoelker, H.J, Manstein, D.J. 登録日 2010-08-10 公開日 2011-05-25 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Inhibition of Myosin ATPase Activity by Halogenated Pseudilins: A Structure-Activity Study. J.Med.Chem., 54, 2011
2Y9E	Structural basis for the allosteric interference of myosin function by mutants G680A and G680V of Dictyostelium myosin-2 分子名称: MYOSIN-2 著者 Preller, M, Bauer, S, Adamek, N, Fujita-Becker, S, Fedorov, R, Geeves, M.A, Manstein, D.J. 登録日 2011-02-14 公開日 2011-07-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.397 Å) 主引用文献 Structural Basis for the Allosteric Interference of Myosin Function by Reactive Thiol Region Mutations G680A and G680V. J.Biol.Chem., 286, 2011
8QYQ	Beta-cardiac myosin S1 fragment in the pre-powerstroke state complexed to Mavacamten 分子名称: 6-[[(1~{S})-1-phenylethyl]amino]-3-propan-2-yl-1~{H}-pyrimidine-2,4-dione, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... 著者 Robert-Paganin, J, Kikuti, C, Auguin, D, Rety, S, David, A, Houdusse, A. 登録日 2023-10-26 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction. Biorxiv, 2023
8QYP	Beta-cardiac myosin motor domain in the pre-powerstroke state 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Myosin-7, ... 著者 Robert-Paganin, J, Kikuti, C, Auguin, D, Rety, S, David, A, Houdusse, A. 登録日 2023-10-26 公開日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.759 Å) 主引用文献 Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction. Biorxiv, 2023

<12345678910>