3BZ7

Crystal Structures of (S)-(-)-Blebbistatin Analogs bound to Dictyostelium discoideum myosin II

Summary for 3BZ7

Entry DOI	10.2210/pdb3bz7/pdb
Related	1YV3 3BZ8 3BZ9
Descriptor	Myosin-2 heavy chain, non muscle, MAGNESIUM ION, VANADATE ION, ... (6 entities in total)
Functional Keywords	myosin inhibitor, motor domain, blebbistatin analogue, actin-binding, atp-binding, calmodulin-binding, coiled coil, cytoplasm, methylation, motor protein, nucleotide-binding, phosphoprotein, contractile protein
Biological source	Dictyostelium discoideum
Cellular location	Cytoplasm, cell cortex: P08799
Total number of polymer chains	1
Total formula weight	87630.19
Authors	Allingham, J.S.,Rayment, I. (deposition date: 2008-01-17, release date: 2008-02-19, Last modification date: 2023-08-30)
Primary citation	Lucas-Lopez, C.,Allingham, J.S.,Lebl, T.,Lawson, C.P.,Brenk, R.,Sellers, J.R.,Rayment, I.,Westwood, N.J. The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design. Org.Biomol.Chem., 6:2076-2084, 2008 Cited by PubMed: 18528569 DOI: 10.1039/b801223g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation