8QYP

Beta-cardiac myosin motor domain in the pre-powerstroke state

Summary for 8QYP

Entry DOI	10.2210/pdb8qyp/pdb
Descriptor	Myosin-7, ADENOSINE-5'-DIPHOSPHATE, VANADATE ION, ... (5 entities in total)
Functional Keywords	cardiac myosin modulators inherited cardiomyopathies, contractile protein
Biological source	Bos taurus (cattle)
Total number of polymer chains	1
Total formula weight	89681.34
Authors	Robert-Paganin, J.,Kikuti, C.,Auguin, D.,Rety, S.,David, A.,Houdusse, A. (deposition date: 2023-10-26, release date: 2023-12-13)
Primary citation	Auguin, D.,Robert-Paganin, J.,Rety, S.,Kikuti, C.,David, A.,Theumer, G.,Schmidt, A.W.,Knolker, H.J.,Houdusse, A. Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite antagonistic effects in heart contraction. Biorxiv, 2023 Cited by PubMed: 38014327 DOI: 10.1101/2023.11.15.567213 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.759 Å)

Structure validation