PDB: 594 件ウェブページステータス検索Chemie searchBIRD

---

2RSY	Solution structure of the SH2 domain of Csk in complex with a phosphopeptide from Cbp 分子名称: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Tyrosine-protein kinase CSK 著者 Tanaka, H, Akagi, K, Oneyama, C, Tanaka, M, Sasaki, Y, Kanou, T, Lee, Y, Yokogawa, D, Debenecker, M, Nakagawa, A, Okada, M, Ikegami, T. 登録日 2012-09-10 公開日 2013-04-10 最終更新日 2019-12-25 実験手法 SOLUTION NMR 主引用文献 Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains. J.Biol.Chem., 288, 2013
2ROR	Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76 分子名称: 15-meric peptide from Lymphocyte cytosolic protein 2, Proto-oncogene vav 著者 Tanaka, M, Kasai, T, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2008-04-08 公開日 2009-04-21 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76 To be Published
2VIF	Crystal structure of SOCS6 SH2 domain in complex with a c-KIT phosphopeptide 分子名称: 1,2-ETHANEDIOL, MAST/STEM CELL GROWTH FACTOR RECEPTOR, SUPPRESSOR OF CYTOKINE SIGNALLING 6 著者 Bullock, A, Pike, A.C.W, Savitsky, P, Keates, T, Pilka, E.S, von Delft, F, Edwards, A, Weigelt, J, Arrowsmith, C.H, Knapp, S. 登録日 2007-11-30 公開日 2007-12-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural Basis for C-Kit Inhibition by the Suppressor of Cytokine Signaling 6 (Socs6) Ubiquitin Ligase. J.Biol.Chem., 286, 2011
2RVF	Solution NMR structure of Monosiga brevicollis CRK/CRKL homolog (crka1) SH2 domain 分子名称: Predicted protein 著者 Kasai, T, Pawlak, J, Imamoto, A, Kigawa, T. 登録日 2015-09-24 公開日 2016-09-21 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 A pre-metazoan origin of the CRK gene family and co-opted signaling network Sci Rep, 6, 2016
3MXC	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. 分子名称: AICD peptide, Growth factor receptor-bound protein 2 著者 Sen, U, Das, S. 登録日 2010-05-07 公開日 2011-05-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
3MXY	Structures of Grb2-SH2 Domain and AICD peptide Complexes Reveal a Conformational Switch and Their Functional Implications. 分子名称: AICD peptide E683V variant, Growth factor receptor-bound protein 2 著者 Sen, U, Das, S. 登録日 2010-05-08 公開日 2011-05-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Functional Implications of the Conformational Switch in AICD Peptide upon Binding to Grb2-SH2 Domain. J.Mol.Biol., 414, 2011
2QMS	Crystal structure of a signaling molecule 分子名称: Growth factor receptor-bound protein 7, SULFATE ION 著者 Porter, C.J, Wilce, M.C, Wilce, J.A. 登録日 2007-07-16 公開日 2008-07-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation. Bmc Struct.Biol., 7, 2007
3MAZ	Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide 分子名称: CheD family protein, MALONATE ION, Signal-transducing adaptor protein 1 著者 Kaneko, T, Huang, H, Zhao, B, Li, L, Liu, H, Voss, C.K, Wu, C, Schiller, M.R, Li, S.S. 登録日 2010-03-24 公開日 2010-05-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Loops govern SH2 domain specificity by controlling access to binding pockets. Sci.Signal., 3, 2010
3N84	Crystal Structure of the Grb2 SH2 Domain in Complex with a 23-Membered Macrocyclic Ligand Having the Sequence pYVNVP 分子名称: 23-membered peptide-like macrocyclic ligand, CHLORIDE ION, GLYCEROL, ... 著者 Clements, J.H, Martin, S.F. 登録日 2010-05-27 公開日 2011-01-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3N8M	Crystal Structure of the Grb2 SH2 Domain in Complex with An Acyclic Ligand Having the Sequence pYVNVP 分子名称: GLYCEROL, Growth factor receptor-bound protein 2, PEPTIDE 著者 Whiddon, B.B, Clements, J.H, Martin, S.F. 登録日 2010-05-28 公開日 2010-12-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
4XZ0	ZAP-70-tSH2:compound-A complex 分子名称: 1-(3-{5-[(3-chlorobenzyl)sulfonyl]-1H-tetrazol-1-yl}phenyl)ethanone, SULFATE ION, Tyrosine-protein kinase ZAP-70 著者 Barros, T, Kuriyan, J, Visperas, P.R, Winger, J.A. 登録日 2015-02-03 公開日 2015-06-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. Biochem. J., 465, 2015
3N7Y	Crystal Structure of the Grb2 SH2 Domain in Complex with a 20-Membered Macrocyclic Ligand Having the Sequence pYVNV 分子名称: 20-membered peptide-like macrocyclic ligand, Growth factor receptor-bound protein 2 著者 Whiddon, B.B, Clements, J.H, Martin, S.F. 登録日 2010-05-27 公開日 2011-01-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Thermodynamic and Structural Effects of Macrocyclization as a Constraining Method in Protein-Ligand Interactions. ACS MED.CHEM.LETT., 1, 2010
3KFJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... 著者 Clements, J.H. 登録日 2009-10-27 公開日 2010-03-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization. J.Am.Chem.Soc., 131, 2009
5AUL	PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex 分子名称: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, T-cell-specific surface glycoprotein CD28 著者 Inaba, S, Numoto, N, Morii, H, Ikura, T, Oda, M, Ito, N. 登録日 2015-04-28 公開日 2016-05-25 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
1WQU	Solution structure of the human FES SH2 domain 分子名称: Proto-oncogene tyrosine-protein kinase FES/FPS 著者 Scott, A, Pantoja-Uceda, D, Koshiba, S, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Tanaka, A, Sugano, S, Yokoyama, S, Guntert, P, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-10-02 公開日 2005-06-14 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes J.Biomol.NMR, 31, 2005
1X0N	NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor 分子名称: 4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID, Growth factor receptor-bound protein 2 著者 Ogura, K, Shiga, T, Yuzawa, S, Yokochi, M, Burke, T.R, Inagaki, F. 登録日 2005-03-24 公開日 2005-04-19 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor To be Published
4P9V	Grb2 SH2 complexed with a pTyr-Ac6cN-Asn tripeptide 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, PHQ-PTR-02K-ASN-NH2 著者 Clements, J.H, Martin, S.F. 登録日 2014-04-06 公開日 2014-06-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
4P9Z	Grb2 SH2 complexed with a pTyr-Ac6c-Asn tripeptide 分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ... 著者 Clements, J.H, Martin, S.F. 登録日 2014-04-06 公開日 2014-06-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Protein-ligand interactions: Probing the energetics of a putative cation-pi interaction. Bioorg.Med.Chem.Lett., 24, 2014
1X6C	Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 分子名称: Tyrosine-protein phosphatase, non-receptor type 6 著者 Sato, M, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-17 公開日 2005-11-17 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structures of the SH2 domain of human protein-tyrosine phosphatase SHP-1 To be Published
5GJI	PI3K p85 N-terminal SH2 domain/CD28-derived peptide complex 分子名称: GLYCEROL, Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION, ... 著者 Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M. 登録日 2016-06-30 公開日 2016-12-14 最終更新日 2017-05-10 実験手法 X-RAY DIFFRACTION (0.9 Å) 主引用文献 Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
5GJH	Gads SH2 domain/CD28-derived peptide complex 分子名称: GRB2-related adapter protein 2, T-cell-specific surface glycoprotein CD28 著者 Inaba, S, Numoto, N, Morii, H, Ogawa, S, Ikura, T, Abe, R, Ito, N, Oda, M. 登録日 2016-06-30 公開日 2016-12-14 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins J. Biol. Chem., 292, 2017
1ZFP	GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN COMPLEXED WITH A PHOSPHOTYROSYL PENTAPEPTIDE 分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR-DERIVED PEPTIDE, GROWTH FACTOR RECEPTOR BINDING PROTEIN, ZINC ION 著者 Rahuel, J. 登録日 1998-03-26 公開日 1999-03-30 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands. J.Mol.Biol., 279, 1998
1Z3K	Structural Insight into the Binding Diversity between the Tyr-Phosphorylated Human EphrinBs and Nck2 SH2 Domain 分子名称: Cytoplasmic protein NCK2 著者 Ran, X, Song, J. 登録日 2005-03-14 公開日 2005-03-29 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain. J.Biol.Chem., 280, 2005
8ATK	The SH2 domain of mouse SH2B1 分子名称: SH2B adapter protein 1 著者 Fowler, N.J, Williamson, M.P, Albalwi, M.F. 登録日 2022-08-23 公開日 2023-05-24 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Improved methodology for protein NMR structure calculation using hydrogen bond restraints and ANSURR validation: The SH2 domain of SH2B1. Structure, 31, 2023
6ICG	Grb2 SH2 domain in phosphopeptide free form 分子名称: GLYCEROL, Growth factor receptor-bound protein 2, SULFATE ION 著者 Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M. 登録日 2018-09-06 公開日 2019-07-17 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Structural and functional properties of Grb2 SH2 dimer in CD28 binding. Biophys Physicobio., 16, 2019

<12345678910111213141516>