4K99
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![BU of 4k99 by Molmil](/molmil-images/mine/4k99) | Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppdG(2 ,5 )pdG | 分子名称: | 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, 3'-deoxy-guanosine 5'-monophosphate, Cyclic GMP-AMP synthase, ... | 著者 | Gao, P, Wu, Y, Patel, D.J. | 登録日 | 2013-04-19 | 公開日 | 2013-05-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153, 2013
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7FTL
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![BU of 7ftl by Molmil](/molmil-images/mine/7ftl) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 8-chloro-2-(2-hydroxyphenyl)quinoline-4-carboxylic acid | 分子名称: | (2P)-8-chloro-2-(2-hydroxyphenyl)quinoline-4-carboxylic acid, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Brunner, M, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FTU
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![BU of 7ftu by Molmil](/molmil-images/mine/7ftu) | Crystal Structure of human cyclic GMP-AMP synthase in complex with (Z)-N-[4-(4-chlorophenyl)sulfonylphenyl]-2-cyano-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide | 分子名称: | (2Z)-N-[4-(4-chlorobenzene-1-sulfonyl)phenyl]-2-cyano-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide, ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, ... | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FU5
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![BU of 7fu5 by Molmil](/molmil-images/mine/7fu5) | Crystal Structure of human cyclic GMP-AMP synthase | 分子名称: | (8S)-2-{[(3-fluoro[1,1'-biphenyl]-4-yl)methyl]amino}-5-propyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one, Cyclic GMP-AMP synthase, SULFATE ION, ... | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FU7
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![BU of 7fu7 by Molmil](/molmil-images/mine/7fu7) | |
7FTP
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![BU of 7ftp by Molmil](/molmil-images/mine/7ftp) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(4-chlorophenyl)-10,11-dimethoxy-7-methyl-2,4,6-triazatricyclo[7.3.1.05,13]trideca-1(12),2,4,7,9(13),10-hexaene | 分子名称: | 4-(4-chlorophenyl)-7,8-dimethoxy-5-methyl-4H-pyrido[2,3,4-de]quinazoline, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Zhang, Z, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FTQ
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![BU of 7ftq by Molmil](/molmil-images/mine/7ftq) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-5-fluoro-4-methylphenyl)-1H-benzimidazole-4-carboxylic acid | 分子名称: | (5M)-5-(2-chloro-5-fluoro-4-methylphenyl)-1H-benzimidazole-7-carboxylic acid, Cyclic GMP-AMP synthase, PHOSPHATE ION, ... | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Zhou, C, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FTW
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![BU of 7ftw by Molmil](/molmil-images/mine/7ftw) | |
7FTY
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![BU of 7fty by Molmil](/molmil-images/mine/7fty) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[(4-phenylphenyl)methylamino]-5-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one:2,2,2-trifluoroacetic acid | 分子名称: | (8R)-2-{[([1,1'-biphenyl]-4-yl)methyl]amino}-5-propyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FTZ
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![BU of 7ftz by Molmil](/molmil-images/mine/7ftz) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[2-[3-[[(5-bromo-2-hydroxybenzoyl)amino]methyl]anilino]-1,3-thiazol-4-yl]acetic acid | 分子名称: | (2-{3-[(5-bromo-2-hydroxybenzamido)methyl]anilino}-1,3-thiazol-4-yl)acetic acid, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FUQ
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![BU of 7fuq by Molmil](/molmil-images/mine/7fuq) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-4-methylphenyl)-3-phenylbenzimidazole-4-carboxylic acid | 分子名称: | (5M)-5-(2-chloro-4-methylphenyl)-1-phenyl-1H-benzimidazole-7-carboxylic acid, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Galley, G, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.757 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FU4
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![BU of 7fu4 by Molmil](/molmil-images/mine/7fu4) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[(2-fluoro-4-phenylphenyl)methylamino]-5-propyl-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one | 分子名称: | (8S)-2-{[(3-fluoro[1,1'-biphenyl]-4-yl)methyl]amino}-5-propyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Hunziker, D, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.926 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FUC
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![BU of 7fuc by Molmil](/molmil-images/mine/7fuc) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-4-methylphenyl)-2-(morpholin-4-ylmethyl)-1H-benzimidazole-4-carboxylic acid | 分子名称: | (6M)-6-(2-chloro-4-methylphenyl)-2-[(morpholin-4-yl)methyl]-1H-benzimidazole-4-carboxylic acid, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Galley, G, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FUE
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![BU of 7fue by Molmil](/molmil-images/mine/7fue) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[[2-chloro-5-(1-methylpyrazol-3-yl)phenyl]methylamino]-5-(2-phenylethyl)-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one | 分子名称: | (8S)-2-({[(5P)-2-chloro-5-(1-methyl-1H-pyrazol-3-yl)phenyl]methyl}amino)-5-(2-phenylethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.169 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FUJ
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![BU of 7fuj by Molmil](/molmil-images/mine/7fuj) | Crystal Structure of human cyclic GMP-AMP synthase in complex with (Z)-2-cyano-N-[4-(3-fluorophenyl)-5-methylsulfonylpyrimidin-2-yl]-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide | 分子名称: | (2Z)-2-cyano-N-[(4P)-4-(3-fluorophenyl)-5-(methanesulfonyl)pyrimidin-2-yl]-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide, 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FUD
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![BU of 7fud by Molmil](/molmil-images/mine/7fud) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-benzyl-2-[[2-chloro-5-(1-methylpyrazol-3-yl)phenyl]methylamino]-4H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one | 分子名称: | (8S)-5-benzyl-2-({[(5P)-2-chloro-5-(1-methyl-1H-pyrazol-3-yl)phenyl]methyl}amino)[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.026 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FUR
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![BU of 7fur by Molmil](/molmil-images/mine/7fur) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone | 分子名称: | 1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one, ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, ... | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FU1
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![BU of 7fu1 by Molmil](/molmil-images/mine/7fu1) | |
7FTF
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![BU of 7ftf by Molmil](/molmil-images/mine/7ftf) | Crystal Structure of apo human cyclic GMP-AMP synthase | 分子名称: | 1,2-ETHANEDIOL, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.508 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FTI
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![BU of 7fti by Molmil](/molmil-images/mine/7fti) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-(4-fluorophenyl)-2-methylpyrazole-3-carboxylic acid | 分子名称: | 3-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-carboxylic acid, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Brunner, M, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FTO
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![BU of 7fto by Molmil](/molmil-images/mine/7fto) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 6-(2-chloro-5-fluoro-4-methylphenyl)-1H-benzimidazole-4-carboxylic acid | 分子名称: | (5M)-5-(2-chloro-5-fluoro-4-methylphenyl)-1H-benzimidazole-7-carboxylic acid, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Zhou, C, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FTR
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![BU of 7ftr by Molmil](/molmil-images/mine/7ftr) | Crystal Structure of human cyclic GMP-AMP synthase in complex with (Z)-N-(4-acetylphenyl)-2-cyano-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide | 分子名称: | (2Z)-N-(4-acetylphenyl)-2-cyano-3-hydroxy-3-(5-methyl-1,2-oxazol-4-yl)prop-2-enamide, ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, ... | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Canesso, R, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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7FTS
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![BU of 7fts by Molmil](/molmil-images/mine/7fts) | |
7FTT
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![BU of 7ftt by Molmil](/molmil-images/mine/7ftt) | |
7FTV
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![BU of 7ftv by Molmil](/molmil-images/mine/7ftv) | Crystal Structure of human cyclic GMP-AMP synthase in complex with 5-bromo-2-hydroxy-N-(quinolin-6-ylmethyl)benzamide | 分子名称: | 5-bromo-2-hydroxy-N-[(quinolin-6-yl)methyl]benzamide, Cyclic GMP-AMP synthase, ZINC ION | 著者 | Leibrock, L, Benz, J, Groebke-Zbinden, K, Hunziker, D, Rudolph, M.G. | 登録日 | 2023-02-08 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.875 Å) | 主引用文献 | Crystal Structure of a human cyclic GMP-AMP synthase complex To be published
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