7FU5

Crystal Structure of human cyclic GMP-AMP synthase

Summary for 7FU5

• Entry DOI: 10.2210/pdb7fu5/pdb
• Group deposition: To be published (G_1002263)
• Descriptor: Cyclic GMP-AMP synthase, ZINC ION, (8S)-2-{[(3-fluoro[1,1'-biphenyl]-4-yl)methyl]amino}-5-propyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one, ... (5 entities in total)
• Functional Keywords: nucleotidyltransferase, cyclic gmp-amp synthase, cgas, dna-binding, activator dna, pattern recognition receptor, innate immune response, viral dna recognition, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 85983.65

Authors

Leibrock, L.,Benz, J.,Groebke-Zbinden, K.,Rudolph, M.G. (deposition date: 2023-02-08, release date: 2024-02-21)

• Primary citation: Groebke-Zbinden, K.,Vandemeulebroucke, A.,Hilbert, M.,Rudolph, M.G.; Crystal Structure of a human cyclic GMP-AMP synthase complex; To be published,

Experimental method

X-RAY DIFFRACTION (2.18 Å)