PDB: 7770 件ウェブページステータス検索Chemie searchBIRD

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3FT2	Crystal Structure of a citrulline peptide variant of the minor histocompatibility peptide HA-1 in complex with HLA-A2 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... 著者 Reiser, J.-B, Gras, S, Chouquet, A, Le Gorrec, M, Spierings, E, Goulmy, E, Housset, D. 登録日 2009-01-12 公開日 2009-04-28 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele. J.Immunol., 182, 2009
3FSO	Crystal structure of the Calx-beta domain of integrin beta4, calcium soak 分子名称: Integrin beta-4 著者 Alonso-Garcia, N, Ingles-Prieto, A, de Pereda, J.M. 登録日 2009-01-11 公開日 2009-06-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.405 Å) 主引用文献 Structure of the Calx-beta domain of the integrin beta4 subunit: insights into function and cation-independent stability Acta Crystallogr.,Sect.D, 65, 2009
3FT3	Crystal Structure of the minor histocompatibility peptide HA-1His in complex with HLA-A2 分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... 著者 Reiser, J.-B, Gras, S, Chouquet, A, Le Gorrec, M, Spierings, E, Goulmy, E, Housset, D. 登録日 2009-01-12 公開日 2009-04-28 最終更新日 2021-10-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Steric hindrance and fast dissociation explain the lack of immunogenicity of the minor histocompatibility HA-1Arg Null allele. J.Immunol., 182, 2009
3FTX	Leukotriene A4 hydrolase in complex with dihydroresveratrol and bestatin 分子名称: 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol, ACETATE ION, ... 著者 Davies, D.R. 登録日 2009-01-13 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
3FU0	Leukotriene A4 hydrolase in complex with fragment 4-(4-fluorobenzoyl)pyridine 分子名称: (4-fluorophenyl)(pyridin-4-yl)methanone, ACETATE ION, IMIDAZOLE, ... 著者 Davies, D.R. 登録日 2009-01-13 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
3FUI	Leukotriene A4 hydrolase in complex with N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline 分子名称: IMIDAZOLE, Leukotriene A-4 hydrolase, N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline, ... 著者 Davies, D.R. 登録日 2009-01-14 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
3FUH	Leukotriene A4 hydrolase in complex with fragment 5-hydroxyindole and bestatin 分子名称: 1H-indol-5-ol, 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, IMIDAZOLE, ... 著者 Davies, D.R. 登録日 2009-01-14 公開日 2009-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J.Med.Chem., 52, 2009
3FXV	Identification of an N-oxide pyridine GW4064 analogue as a potent FXR agonist 分子名称: 12-meric peptide from Nuclear receptor coactivator 1, 6-(4-{[3-(3,5-dichloropyridin-4-yl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}-2-methylphenyl)-1-methyl-1H-indole-3-carbox ylic acid, NR1H4 protein 著者 Feng, S, Yang, M, He, Y, Chen, L, Zhang, Z, Wang, Z, Hong, D, Richter, H, Benson, G.M, Bleicher, K, Grether, U, Martin, R, Plancher, J.-M, Kuhn, B, Rudolph, M.G. 登録日 2009-01-21 公開日 2009-04-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist Bioorg.Med.Chem.Lett., 19, 2009
3FYL	GR DNA binding domain:CGT complex 分子名称: 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*CP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*GP*AP*CP*AP*AP*AP*AP*TP*GP*TP*TP*CP*T)-3'), ... 著者 Pufall, M.A, Yamamoto, K.R, Meijsing, S.H. 登録日 2009-01-22 公開日 2009-04-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 DNA binding site sequence directs glucocorticoid receptor structure and activity. Science, 324, 2009
3G3M	Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-iodo-UMP 分子名称: 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, Uridine 5'-monophosphate synthase 著者 Liu, Y, Tang, H.L, Bello, A.M, Poduch, E, Kotra, L.P, Pai, E.F. 登録日 2009-02-02 公開日 2009-03-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J.Med.Chem., 52, 2009
3DVB	X-ray crystal structure of mutant N62V human Carbonic Anhydrase II 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Avvaru, B.S. 登録日 2008-07-18 公開日 2008-11-11 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II. Biochemistry, 47, 2008
3DT1	P38 Complexed with a quinazoline inhibitor 分子名称: Mitogen-activated protein kinase 14, N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide 著者 Herberich, B, Syed, R, Li, V, Tasker, A.S. 登録日 2008-07-14 公開日 2008-10-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold. J.Med.Chem., 51, 2008
3E1R	Midbody targeting of the ESCRT machinery by a non-canonical coiled-coil in CEP55 分子名称: Centrosomal protein of 55 kDa, Programmed cell death 6-interacting protein 著者 Lee, H.H, Elia, N, Ghirlando, R, Lippincott-Schwartz, J, Hurley, J.H. 登録日 2008-08-04 公開日 2008-11-04 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science, 322, 2008
3E1U	The Crystal Structure of the Anti-Viral APOBEC3G Catalytic Domain 分子名称: DNA dC->dU-editing enzyme APOBEC-3G, ZINC ION 著者 Holden, L, Prochnow, C, Chang, Y.P, Bransteitter, R, Chelico, L, Sen, U, Stevens, R.C, Goodman, R.F, Chen, X.S. 登録日 2008-08-04 公開日 2008-10-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications. Nature, 456, 2008
3E7I	Structure of murine inos oxygenase domain with inhibitor AR-C94864 分子名称: (2R)-5-FLUORO-2-(2-THIENYL)-1,2-DIHYDROQUINAZOLIN-4-AMINE, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ... 著者 Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stuehr, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. 登録日 2008-08-18 公開日 2008-10-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
3E4Z	Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II 分子名称: Insulin-degrading enzyme, Insulin-like growth factor II, ZINC ION 著者 Guo, Q, Manolopoulou, M, Tang, W.-J. 登録日 2008-08-12 公開日 2009-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395, 2010
3E7T	Structure of murine iNOS oxygenase domain with inhibitor AR-C102222 分子名称: 1-(6-CYANO-3-PYRIDYLCARBONYL)-5',8'-DIFLUOROSPIRO[PIPERIDINE-4,2'(1'H)-QUINAZOLINE]-4'-AMINE, 7,8-DIHYDROBIOPTERIN, Nitric oxide synthase, ... 著者 Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stuehr, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. 登録日 2008-08-18 公開日 2008-10-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
3E6L	Structure of murine INOS oxygenase domain with inhibitor AR-C132283 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE, Nitric oxide synthase, ... 著者 Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stueh, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. 登録日 2008-08-15 公開日 2008-10-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4, 2008
3FJF	Crystal structure of C83T mutant of Human acidic fibroblast growth factor 分子名称: FORMIC ACID, Heparin-binding growth factor 1 著者 Blaber, M, Lee, J. 登録日 2008-12-14 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine. J.Mol.Biol., 393, 2009
3FJL	Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 3 分子名称: (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide, ACETIC ACID, Dihydroorotate dehydrogenase, ... 著者 Heikkila, T. 登録日 2008-12-14 公開日 2009-06-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
3FFP	X ray structure of the complex between carbonic anhydrase II and LC inhibitors 分子名称: 2-(1,3-thiazol-4-yl)-1H-benzimidazole-5-sulfonamide, BENZOIC ACID, Carbonic anhydrase 2, ... 著者 Temperini, C, Crocetti, L, Scozzafava, A, Supuran, C.T. 登録日 2008-12-04 公開日 2009-08-18 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases Bioorg.Med.Chem.Lett., 19, 2009
3FLG	The PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 beta 分子名称: DNA (cytosine-5)-methyltransferase 3B 著者 Amaya, M.F, Zeng, H, MacKenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Botchkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2008-12-18 公開日 2009-03-31 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of the PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 beta To be Published
3FJE	Crystal structure of C83S mutant of Human acidic fibroblast growth factor 分子名称: FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION 著者 Blaber, M, Lee, J. 登録日 2008-12-14 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine. J.Mol.Biol., 393, 2009
3FJH	Crystal structure of C83A mutant of Human acidic fibroblast growth factor 分子名称: FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION 著者 Blaber, M, Lee, J. 登録日 2008-12-14 公開日 2009-10-06 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine. J.Mol.Biol., 393, 2009
3FLS	P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-2-((R)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one 分子名称: 6-(2,4-difluorophenoxy)-8-methyl-2-{[(1R)-1-methyl-2-(methylsulfonyl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase 14 著者 Kuglstatter, A, Ghate, M. 登録日 2008-12-19 公開日 2009-12-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The Discovery of Pamapimod, R1503 and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase To be Published

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