3E7T

Structure of murine iNOS oxygenase domain with inhibitor AR-C102222

Summary for 3E7T

Entry DOI	10.2210/pdb3e7t/pdb
Related	3E65 3E67 3E68 3E6L 3E6N 3E6O 3E6T 3E7G 3E7I 3E7M 3E7S 3EAH 3EAI 3EBD 3EBF 3EJ8
Descriptor	Nitric oxide synthase, inducible, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ... (6 entities in total)
Functional Keywords	nitric oxide synthase, nos, heme, tetrahydrobiopterin, oxidoreductase calmodulin-binding, fad, fmn, iron, metal-binding, nadp, oxidoreductase, polymorphism, zinc
Biological source	Mus musculus (mouse)
Total number of polymer chains	2
Total formula weight	102814.14
Authors	Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stuehr, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D. (deposition date: 2008-08-18, release date: 2008-10-07, Last modification date: 2024-02-21)
Primary citation	Garcin, E.D.,Arvai, A.S.,Rosenfeld, R.J.,Kroeger, M.D.,Crane, B.R.,Andersson, G.,Andrews, G.,Hamley, P.J.,Mallinder, P.R.,Nicholls, D.J.,St-Gallay, S.A.,Tinker, A.C.,Gensmantel, N.P.,Mete, A.,Cheshire, D.R.,Connolly, S.,Stuehr, D.J.,Aberg, A.,Wallace, A.V.,Tainer, J.A.,Getzoff, E.D. Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat.Chem.Biol., 4:700-707, 2008 Cited by PubMed: 18849972 DOI: 10.1038/nchembio.115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation