PDB: 13413 件ウェブページステータス検索Chemie searchBIRD

---

6VVY	Mycobacterium tuberculosis WT RNAP transcription open promoter complex with Sorangicin 分子名称: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. 登録日 2020-02-18 公開日 2020-10-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.42 Å) 主引用文献 The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
6VW0	Mycobacterium tuberculosis RNAP S456L mutant open promoter complex 分子名称: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. 登録日 2020-02-18 公開日 2020-10-21 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.59 Å) 主引用文献 The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
8FPJ	Co-structure of the Human Metapneunomovirus RNA-dependent RNA polymerase with MRK-1 分子名称: 4-(2-aminopropan-2-yl)-N'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide, Phosphoprotein, RNA-directed RNA polymerase L 著者 Fischmann, T.O. 登録日 2023-01-04 公開日 2023-06-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.74 Å) 主引用文献 Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases. Commun Biol, 6, 2023
8FPI	Co-structure of the Respiratory Syncytial Virus RNA-dependent RNA polymerase with MRK-1 分子名称: 4-(2-aminopropan-2-yl)-N'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide, Phosphoprotein, RNA-directed RNA polymerase L 著者 Fischmann, T.O. 登録日 2023-01-04 公開日 2023-06-14 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.52 Å) 主引用文献 Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases. Commun Biol, 6, 2023
6EE8	Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter 分子名称: DNA (60-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. 登録日 2018-08-13 公開日 2018-11-21 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.92 Å) 主引用文献 Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
6OGY	In situ structure of Rotavirus RNA-dependent RNA polymerase at duplex-open state 分子名称: DNA/RNA (5'-D(*(GTG))-R(P*GP*C)-3'), Inner capsid protein VP2, RNA (5'-R(P*AP*GP*CP*C)-3'), ... 著者 Ding, K, Chang, T, Shen, W, Roy, P, Zhou, Z.H. 登録日 2019-04-03 公開日 2019-05-22 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release. Nat Commun, 10, 2019
6M7J	Mycobacterium tuberculosis RNAP with RbpA/us fork and Corallopyronin 分子名称: DNA (26-MER), DNA (31-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. 登録日 2018-08-20 公開日 2018-11-21 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
8EXY	M. tuberculosis RNAP paused complex with B. subtilis NusG and GMPCPP 分子名称: DNA (38-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Vishwakarma, R.K, Murakami, K.S. 登録日 2022-10-26 公開日 2023-02-01 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase. Proc.Natl.Acad.Sci.USA, 120, 2023
8EOF	Mycobacterium tuberculosis transcription elongation complex with Bacillus subtilis NusG (EC_PG) 分子名称: DNA (35-MER), DNA (38-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Vishwakarm, R.K, Murakami, K.S. 登録日 2022-10-03 公開日 2023-02-01 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase. Proc.Natl.Acad.Sci.USA, 120, 2023
8EOT	M. tuberculosis RNAP elongation complex with NusG 分子名称: DNA (31-MER), DNA (33-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Vishwakarma, R.K, Murakami, K.S. 登録日 2022-10-04 公開日 2023-02-01 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase. Proc.Natl.Acad.Sci.USA, 120, 2023
8EOS	M. tuberculosis RNAP elongation complex with NusG and CMPCPP 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (36-MER), DNA (38-MER), ... 著者 Vishwakarma, R.K, Murakami, K.S. 登録日 2022-10-04 公開日 2023-02-01 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase. Proc.Natl.Acad.Sci.USA, 120, 2023
3H3V	Yeast RNAP II containing poly(A)-signal sequence in the active site 分子名称: 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*GP*CP*TP*GP*CP*TP*TP*TP*AP*TP*TP*GP*CP*AP*TP*T)-3', 5'-D(*CP*AP*GP*CP*TP*AP*CP*TP*TP*GP*AP*GP*CP*T)-3', 5'-R(*UP*GP*CP*AP*UP*UP*UP*CP*GP*CP*AP*AP*UP*AP*AP*A)-3', ... 著者 Dengl, S, Cramer, P. 登録日 2009-04-17 公開日 2009-06-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Torpedo Nuclease Rat1 Is Insufficient to Terminate RNA Polymerase II in Vitro J.Biol.Chem., 284, 2009
8HKC	Cryo-EM structure of E. coli RNAP sigma32 complex 分子名称: DNA (54-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Wu, S, Ma, L.X. 登録日 2022-11-25 公開日 2023-05-31 最終更新日 2024-07-03 実験手法 ELECTRON MICROSCOPY (2.49 Å) 主引用文献 Structural Insight into the Mechanism of sigma 32-Mediated Transcription Initiation of Bacterial RNA Polymerase. Biomolecules, 13, 2023
6S2L	FMDV 3D polymerase crystallized in presence of (F)uridylylated VPg peptide 分子名称: GLYCEROL, Genome polyprotein 著者 Verdaguer, N, Ferrer-Orta, C. 登録日 2019-06-21 公開日 2019-07-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 (F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase. Molecules, 24, 2019
8AC2	RNA polymerase- post-terminated, open clamp state 分子名称: DNA Non-template strand, DNA Template strand, DNA-directed RNA polymerase subunit alpha, ... 著者 Dey, S, Weixlbaumer, A. 登録日 2022-07-05 公開日 2022-10-19 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural insights into RNA-mediated transcription regulation in bacteria. Mol.Cell, 82, 2022
7SZJ	Cryo-EM structure of Rifamycin bound to E. coli RNAP and rrnBP1 promoter complex 分子名称: DNA (49-MER), DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2021-11-28 公開日 2022-07-13 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.11 Å) 主引用文献 Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
7SZK	Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex 分子名称: (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2021-11-28 公開日 2022-07-13 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
7M8E	E.coli RNAP-RapA elongation complex 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Shi, W, Liu, B. 登録日 2021-03-29 公開日 2021-08-18 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis for activation of Swi2/Snf2 ATPase RapA by RNA polymerase. Nucleic Acids Res., 49, 2021
4Y3C	I304V 3D polymerase mutant of EMCV 分子名称: 3D polymerase, CHLORIDE ION, GLYCEROL 著者 Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L. 登録日 2015-02-10 公開日 2015-04-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
4WZM	Mutant K18E of RNA dependent RNA polymerase from Foot-and-Mouth Disease Virus complexed with RNA 分子名称: ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... 著者 Verdaguer, N, Ferrer-Orta, C, de la Higuera, N. 登録日 2014-11-20 公開日 2015-05-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition. J.Virol., 89, 2015
4WZQ	Mutant K20E of RNA dependent RNA polymerase 3D from Foot-and-Mouth disease Virus complexed with RNA 分子名称: MANGANESE (II) ION, RNA dependent-RNA polymerase 3D, RNA template, ... 著者 Verdaguer, N, Ferrer-Orta, C. 登録日 2014-11-20 公開日 2015-05-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition. J.Virol., 89, 2015
8HSR	Thermus thermophilus Rho-engaged RNAP elongation complex (composite structure) 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (31-MER), ... 著者 Murayama, Y, Ehara, H, Sekine, S. 登録日 2022-12-20 公開日 2023-05-03 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
4XLN	Crystal structure of T. aquaticus transcription initiation complex containing bubble promoter and RNA 分子名称: DNA (48-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-13 公開日 2015-09-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Structure of a bacterial RNA polymerase holoenzyme open promoter complex. Elife, 4, 2015
4Y2A	Crystal Structure of Coxsackie Virus B3 3D polymerase in complex with GPC-N114 inhibitor 分子名称: 2,2'-[(4-chlorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ... 著者 Vives-Adrian, L, Ferrer-Orta, C, Verdaguer, N. 登録日 2015-02-09 公開日 2015-04-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
4Y34	Crystal Structure of Coxsackievirus B3 3D polymerase in complex with GPC-N143 分子名称: 2,2'-[(4-fluorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ... 著者 Vives-Adrian, L, Ferrer-Orta, C, Cerdaguer, N. 登録日 2015-02-10 公開日 2015-04-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015

<21222324252627282930313233343536>