2XYT
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![BU of 2xyt by Molmil](/molmil-images/mine/2xyt) | Crystal structure of Aplysia californica AChBP in complex with d- tubocurarine | 分子名称: | D-TUBOCURARINE, SOLUBLE ACETYLCHOLINE RECEPTOR | 著者 | Brams, M, Pandya, A, Kuzmin, D, van Elk, R, Krijnen, L, Yakel, J.L, Tsetlin, V, Smit, A.B, Ulens, C. | 登録日 | 2010-11-19 | 公開日 | 2011-03-23 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and D-Tubocurarine by Different Cys-Loop Receptors. Plos Biol., 9, 2011
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4FFL
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![BU of 4ffl by Molmil](/molmil-images/mine/4ffl) | PylC in complex with L-lysine | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CARBONATE ION, ... | 著者 | Quitterer, F, List, A, Beck, P, Bacher, A, Groll, M. | 登録日 | 2012-06-01 | 公開日 | 2012-09-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Biosynthesis of the 22nd genetically encoded amino acid pyrrolysine: structure and reaction mechanism of PylC at 1.5A resolution. J.Mol.Biol., 424, 2012
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2XS1
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![BU of 2xs1 by Molmil](/molmil-images/mine/2xs1) | Crystal Structure of ALIX in complex with the SIVmac239 PYKEVTEDL Late Domain | 分子名称: | GAG POLYPROTEIN, PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN | 著者 | Zhai, Q, Landesman, M, Robinson, H, Sundquist, W.I, Hill, C.P. | 登録日 | 2010-09-24 | 公開日 | 2010-11-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.296 Å) | 主引用文献 | Identification and Structural Characterization of the Alix-Binding Late Domains of Sivmac239 and Sivagmtan-1. J.Virol., 85, 2011
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2Y0L
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2Y1D
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![BU of 2y1d by Molmil](/molmil-images/mine/2y1d) | X-ray structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, DXR, Rv2870c, from Mycobacterium tuberculosis, in complex with a 3,4- dichlorophenyl-substituted fosmidomycin analogue and manganese. | 分子名称: | (1S)-1-(3,4-DICHLOROPHENYL)-3-[FORMYL(HYDROXY)AMINO]PROPYL}PHOSPHONIC ACID, 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, MANGANESE (II) ION | 著者 | Henriksson, L.M, Larsson, A.M.S, Bergfors, T, Bjorkelid, C, Unge, T, Mowbray, S.L, Jones, T.A. | 登録日 | 2010-12-08 | 公開日 | 2011-06-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Design, Synthesis and X-Ray Crystallographic Studies of Alpha-Aryl Substituted Fosmidomycin Analogues as Inhibitors of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase J.Med.Chem, 54, 2011
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8SMP
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![BU of 8smp by Molmil](/molmil-images/mine/8smp) | Xenopus laevis hyaluronan synthase 1, UDP-bound, gating loop inserted state | 分子名称: | Fab15 heavy chain, Fab15 light chain, Hyaluronan synthase 1, ... | 著者 | Gorniak, I, Zimmer, J. | 登録日 | 2023-04-26 | 公開日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Atomistic insights into hyaluronan synthesis, secretion, and length control To Be Published
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2Y1P
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![BU of 2y1p by Molmil](/molmil-images/mine/2y1p) | Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, complexed with citrate | 分子名称: | 2', 3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE, CITRIC ACID, ... | 著者 | Myllykoski, M, Kursula, P. | 登録日 | 2010-12-09 | 公開日 | 2011-12-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Myelin 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase: Active-Site Ligand Binding and Molecular Conformation. Plos One, 7, 2012
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8SMO
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2Y2M
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![BU of 2y2m by Molmil](/molmil-images/mine/2y2m) | PENICILLIN-BINDING PROTEIN 1B (PBP-1B) IN COMPLEX WITH AN ALKYL BORONATE (E08) | 分子名称: | CHLORIDE ION, PENICILLIN-BINDING PROTEIN 1B, SODIUM ION, ... | 著者 | Contreras-Martel, C, Amoroso, A, Woon, E.C, Zervosen, A, Inglis, S, Martins, A, Verlaine, O, Rydzik, A, Job, V, Luxen, A, Joris, B, Schofield, C.J, Dessen, A. | 登録日 | 2010-12-15 | 公開日 | 2011-08-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Structure-Guided Design of Cell Wall Biosynthesis Inhibitors that Overcome Beta-Lactam Resistance in Staphylococcus Aureus (Mrsa). Acs Chem.Biol., 6, 2011
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2XWZ
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![BU of 2xwz by Molmil](/molmil-images/mine/2xwz) | STRUCTURE OF THE RECOMBINANT NATIVE NITRITE REDUCTASE FROM ALCALIGENES XYLOSOXIDANS complexed with nitrite | 分子名称: | ACETATE ION, COPPER (II) ION, DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE, ... | 著者 | Antonyuk, S.V, Leferink, N.G.H, Han, C, Heyes, D.J, Rigby, S.E.J, Hough, M.A, Eady, R.R, Scrutton, N.S, Hasnain, S.S. | 登録日 | 2010-11-06 | 公開日 | 2011-05-18 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Proton-Coupled Electron Transfer in the Catalytic Cycle of Alcaligenes Xylosoxidans Copper-Dependent Nitrite Reductase. Biochemistry, 50, 2011
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2Y31
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![BU of 2y31 by Molmil](/molmil-images/mine/2y31) | Simocyclinone C4 bound form of TetR-like repressor SimR | 分子名称: | CALCIUM ION, CHLORIDE ION, PENTAETHYLENE GLYCOL, ... | 著者 | Le, T.B.K, Stevenson, C.E.M, Fiedler, H.-P, Maxwell, A, Lawson, D.M, Buttner, M.J. | 登録日 | 2010-12-17 | 公開日 | 2011-03-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structures of the Tetr-Like Simocyclinone Efflux Pump Repressor, Simr, and the Mechanism of Ligand-Mediated Derepression. J.Mol.Biol., 408, 2011
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2Y41
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![BU of 2y41 by Molmil](/molmil-images/mine/2y41) | Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with IPM and MN | 分子名称: | 3-ISOPROPYLMALATE DEHYDROGENASE, 3-ISOPROPYLMALIC ACID, MANGANESE (II) ION | 著者 | Graczer, E, merlin, A, Singh, R.K, Manikandan, K, Zavodsky, P, Weiss, M.S, Vas, M. | 登録日 | 2011-01-04 | 公開日 | 2011-01-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase. Mol.Biosyst., 7, 2011
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2XYU
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![BU of 2xyu by Molmil](/molmil-images/mine/2xyu) | Crystal structure of EphA4 kinase domain in complex with VUF 12058 | 分子名称: | 5-(5-FLUORO-2-METHYLPHENYL)-6,7,8,9-TETRAHYDRO-3H-PYRAZOLO[3,4-C]ISOQUINOLIN-1-AMINE, EPHRIN TYPE-A RECEPTOR 4,, GLYCEROL | 著者 | Farenc, C.J.A, Celie, P.H.N, vanLinden, O.P.J, Siegal, G. | 登録日 | 2010-11-19 | 公開日 | 2011-11-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.117 Å) | 主引用文献 | Fragment Based Lead Discovery of Small Molecule Inhibitors for the Epha4 Receptor Tyrosine Kinase. Eur.J.Med.Chem., 47, 2012
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2Y08
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![BU of 2y08 by Molmil](/molmil-images/mine/2y08) | Structure of the substrate-free FAD-dependent tirandamycin oxidase TamL | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | 著者 | Carlson, J.C, Li, S, Gunatilleke, S.S, Anzai, Y, Burr, D.A, Podust, L.M, Sherman, D.H. | 登録日 | 2010-11-30 | 公開日 | 2011-06-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes Nat.Chem, 3, 2011
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8RHK
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![BU of 8rhk by Molmil](/molmil-images/mine/8rhk) | Yeast 20S proteasome in complex with a linear oxindole epoxyketone (compound 6) | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Linear oxindole epoxyketone, ... | 著者 | Goetz, M.G, Godwin, K, Price, R, Dorn, R, Merrill-Steskal, G, Hansen, H, Klemmer, W, Produturi, G, Rocha, M, Palmer, M, Molacek, L, Strater, Z, Groll, M. | 登録日 | 2023-12-15 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Macrocyclic Oxindole Peptide Epoxyketones-A Comparative Study of Macrocyclic Inhibitors of the 20S Proteasome. Acs Med.Chem.Lett., 15, 2024
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2Y58
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![BU of 2y58 by Molmil](/molmil-images/mine/2y58) | Fragment growing induces conformational changes in acetylcholine- binding protein: A structural and thermodynamic analysis - (Compound 6) | 分子名称: | CHLORIDE ION, SOLUBLE ACETYLCHOLINE RECEPTOR, SULFATE ION, ... | 著者 | Rucktooa, P, Edink, E, deEsch, I.J.P, Sixma, T.K. | 登録日 | 2011-01-12 | 公開日 | 2011-06-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Fragment Growing Induces Conformational Changes in Acetylcholine-Binding Protein: A Structural and Thermodynamic Analysis. J.Am.Chem.Soc., 133, 2011
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2Y22
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![BU of 2y22 by Molmil](/molmil-images/mine/2y22) | Human AlphaB-crystallin Domain (residues 67-157) | 分子名称: | ALPHA-CRYSTALLIN B | 著者 | Naylor, C.E, Bagneris, C, Clark, A.R, Keep, N.H, Slingsby, C. | 登録日 | 2010-12-13 | 公開日 | 2011-03-02 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Crystal Structure of R120G Disease Mutant of Human Alphab-Crystallin Domain Dimer Shows Closure of a Groove J.Mol.Biol., 408, 2011
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2Y3A
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![BU of 2y3a by Molmil](/molmil-images/mine/2y3a) | Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941 | 分子名称: | 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM | 著者 | Zhang, X, Vadas, O, Perisic, O, Williams, R.L. | 登録日 | 2010-12-20 | 公開日 | 2011-03-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism. Mol.Cell, 41, 2011
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2XP2
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![BU of 2xp2 by Molmil](/molmil-images/mine/2xp2) | Structure of the Human Anaplastic Lymphoma Kinase in Complex with Crizotinib (PF-02341066) | 分子名称: | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, TYROSINE-PROTEIN KINASE RECEPTOR | 著者 | McTigue, M, Deng, Y, Liu, W, Brooun, A, Timofeevski, S, Marrone, T, Cui, J.J. | 登録日 | 2010-08-24 | 公開日 | 2010-09-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure Based Drug Design of Crizotinib (Pf-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (C-met) Kinase and Anaplastic Lymphoma Kinase (Alk). J.Med.Chem, 54, 2011
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8ROO
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![BU of 8roo by Molmil](/molmil-images/mine/8roo) | Crystal structure of HLA B*18:01 in complex with YERMCNIL, an 8-mer epitope from Influenza A | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, Influenza A derived peptide/Nucleoprotein, ... | 著者 | Murdolo, L.D, Maddumage, J.C, Gras, S. | 登録日 | 2024-01-11 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Crystal structure of HLA B*18:01 in complex with YERMCNIL, an 8-mer epitope from Influenza A To Be Published
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8R80
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![BU of 8r80 by Molmil](/molmil-images/mine/8r80) | SARS-CoV-2 Delta RBD in complex with XBB-9 Fab and an anti-Fab nanobody | 分子名称: | Spike protein S1, XBB-9 Fab heavy chain, XBB-9 Fab light chain, ... | 著者 | Zhou, D, Ren, J, Stuart, D.I. | 登録日 | 2023-11-27 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (4.03 Å) | 主引用文献 | A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity. Cell Rep Med, 5, 2024
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2XKF
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![BU of 2xkf by Molmil](/molmil-images/mine/2xkf) | Structure of Nek2 bound to aminopyrazine compound 2 | 分子名称: | 1-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]piperidine-4-carboxylic acid, CHLORIDE ION, SERINE/THREONINE-PROTEIN KINASE NEK2 | 著者 | Mas-Droux, C, Bayliss, R. | 登録日 | 2010-07-07 | 公開日 | 2010-10-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization. J.Med.Chem., 53, 2010
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8ROP
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![BU of 8rop by Molmil](/molmil-images/mine/8rop) | Crystal structure of HLA B*18:01 in complex with QEIRTFSF, an 8-mer epitope from Influenza A | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, CHLORIDE ION, ... | 著者 | Murdolo, L.D, Maddumage, J.C, Gras, S. | 登録日 | 2024-01-12 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Crystal structure of HLA B*18:01 in complex with QEIRTFSF, an 8-mer epitope from Influenza A To Be Published
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2XPG
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![BU of 2xpg by Molmil](/molmil-images/mine/2xpg) | Crystal structure of a MHC class I-peptide complex | 分子名称: | BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-3 ALPHA CHAIN, ... | 著者 | McMahon, R.M, Friis, L, Siebold, C, Friese, M.A, Fugger, L, Jones, E.Y. | 登録日 | 2010-08-26 | 公開日 | 2011-04-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure of Hla-A0301 in Complex with a Peptide of Proteolipid Protein: Insights Into the Role of Hla-A Alleles in Susceptibility to Multiple Sclerosis Acta Crystallogr.,Sect.D, 67, 2011
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2XL7
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![BU of 2xl7 by Molmil](/molmil-images/mine/2xl7) | Structure and metal-loading of a soluble periplasm cupro-protein: Cu- CucA-closed (SeMet) | 分子名称: | CHLORIDE ION, COPPER (II) ION, SLL1785 PROTEIN, ... | 著者 | Waldron, K.J, Firbank, S.J, Dainty, S.J, Perez-Rama, M, Tottey, S, Robinson, N.J. | 登録日 | 2010-07-19 | 公開日 | 2010-08-11 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure and Metal Loading of a Soluble Periplasm Cuproprotein. J.Biol.Chem., 285, 2010
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