7EGN
| Crystal structure of the P450 BM3 heme domain mutant F87A in complex with N-imidazolyl-hexanoyl-L-phenylalanine and hydroxylamine | 分子名称: | (2S)-2-(6-imidazol-1-ylhexanoylamino)-3-phenyl-propanoic acid, Bifunctional cytochrome P450/NADPH--P450 reductase, GLYCEROL, ... | 著者 | Jiang, Y, Dong, S, Feng, Y, Cong, Z. | 登録日 | 2021-03-24 | 公開日 | 2021-08-18 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | H-Bonding Networks Dictate the Molecular Mechanism of H2O2 Activation by P450 Acs Catalysis, 11, 2021
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7NL6
| Crystal Structure of DC-SIGN in complex with a triazole-based glycomimetic ligand | 分子名称: | CALCIUM ION, DC-SIGN, CRD domain, ... | 著者 | Jakob, R.P, Cramer, J, Lakkaichi, A, Aliu, B, Cattaneo, I, Klein, S, Jiang, X, Rabbani, S, Schwardt, O, Ernst, B, Maier, T. | 登録日 | 2021-02-22 | 公開日 | 2021-10-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2. J.Am.Chem.Soc., 143, 2021
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6E7M
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7V63
| Structure of dimeric uPAR at low pH | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor | 著者 | Yuan, C, Huang, M. | 登録日 | 2021-08-19 | 公開日 | 2021-12-22 | 最終更新日 | 2022-04-06 | 実験手法 | X-RAY DIFFRACTION (2.906 Å) | 主引用文献 | Crystal structure and cellular functions of uPAR dimer Nat Commun, 13, 2022
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4MWY
| Shanghai N9-laninamivir | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, CALCIUM ION, ... | 著者 | Wu, Y, Qi, J.X, Gao, F, Gao, G.F. | 登録日 | 2013-09-25 | 公開日 | 2013-11-20 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses Cell Res., 23, 2013
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6AYC
| Naegleria fowleri CYP51-itraconazole complex | 分子名称: | 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, PROTOPORPHYRIN IX CONTAINING FE, Protein CYP51 | 著者 | Debnath, A, Calvet, C.M, Jennings, G, Zhou, W, Aksenov, A, Luth, M, Abagyan, R, Nes, W.D, McKerrow, J.H, Podust, L.M. | 登録日 | 2017-09-08 | 公開日 | 2017-11-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). PLoS Negl Trop Dis, 11, 2017
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7VDE
| 3.6 A structure of the human hemoglobin | 分子名称: | Hemoglobin subunit alpha, Hemoglobin subunit beta, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Fan, H.C, Zhang, Y, Sun, F. | 登録日 | 2021-09-06 | 公開日 | 2021-12-29 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | A cryo-electron microscopy support film formed by 2D crystals of hydrophobin HFBI. Nat Commun, 12, 2021
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6AYW
| The structure of human CamKII with bound inhibitor | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Calcium/calmodulin-dependent protein kinase type II subunit delta, N-[2-(dimethylamino)ethyl]-3-[6-(thiophen-2-yl)imidazo[1,2-b]pyridazin-3-yl]benzamide | 著者 | Somoza, J.R, Villasenor, A.G. | 登録日 | 2017-09-08 | 公開日 | 2017-11-15 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | The structure of human CamKII with bound inhibitor To Be Published
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7NL7
| Crystal Structure of DC-SIGN in complex with a triazole-based glycomimetic ligand | 分子名称: | 3-Aminopropyl 2-deoxy-2-(4-phenyl-1,2,3-triazol-1-yl)-alpha-D-mannopyranoside, CALCIUM ION, DC-SIGN, ... | 著者 | Jakob, R.P, Cramer, J, Lakkaichi, A, Aliu, B, Cattaneo, I, Klein, S, Jiang, X, Rabbani, S, Schwardt, O, Ernst, B, Maier, T. | 登録日 | 2021-02-22 | 公開日 | 2021-10-27 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Sweet Drugs for Bad Bugs: A Glycomimetic Strategy against the DC-SIGN-Mediated Dissemination of SARS-CoV-2. J.Am.Chem.Soc., 143, 2021
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6EH0
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4N1E
| Structural evidence for antigen receptor evolution | 分子名称: | Lysozyme C, immunoglobulin variable light chain domain | 著者 | Langley, D.B, Rouet, R, Stock, D, Christ, D. | 登録日 | 2013-10-04 | 公開日 | 2014-10-29 | 最終更新日 | 2018-04-18 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Structural reconstruction of protein ancestry. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5UYJ
| Crystal Structure of the Human CAMKK2B | 分子名称: | 2-cyclopentyl-4-(7-methoxyquinolin-4-yl)benzoic acid, Calcium/calmodulin-dependent protein kinase kinase 2 | 著者 | Counago, R.M, Drewry, D, Arruda, P, Edwards, A.M, Gileadi, O, Structural Genomics Consortium (SGC) | 登録日 | 2017-02-24 | 公開日 | 2017-04-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal Structure of the Human CAMKK2B To Be Published
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4N32
| Structure of langerin CRD with alpha-Me-GlcNAc. | 分子名称: | C-type lectin domain family 4 member K, CALCIUM ION, methyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside | 著者 | Feinberg, H, Rowntree, T.J.W, Tan, S.L.W, Drickamer, K, Weis, W.I, Taylor, M.E. | 登録日 | 2013-10-06 | 公開日 | 2013-11-20 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Common polymorphisms in human langerin change specificity for glycan ligands. J.Biol.Chem., 288, 2013
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5UZ8
| Crystal Structure of Mouse Cadherin-23 EC22-24 | 分子名称: | CALCIUM ION, CHLORIDE ION, Cadherin-23, ... | 著者 | Patel, A, Jaiganesh, A, Sotomayor, M. | 登録日 | 2017-02-25 | 公開日 | 2018-02-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness. Structure, 26, 2018
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6BA5
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6EIV
| DYRK1A in complex with JWD-065 | 分子名称: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, ~{N}-[3-[[4-azanyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1,3-thiazol-5-yl]carbonyl]phenyl]propanamide | 著者 | Rothweiler, U. | 登録日 | 2017-09-19 | 公開日 | 2018-08-29 | 最終更新日 | 2018-09-26 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors. J. Med. Chem., 61, 2018
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6BCZ
| Crystal structure of human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl (2-{[(2R)-3-oxo-2-[(propan-2-yl)amino]-3-{[(pyridin-3-yl)methyl]amino}propyl]sulfanyl}ethyl)carbamate | 著者 | Sevrioukova, I. | 登録日 | 2017-10-20 | 公開日 | 2017-12-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Inhibition of Human CYP3A4 by Rationally Designed Ritonavir-Like Compounds: Impact and Interplay of the Side Group Functionalities. Mol Pharm., 15, 2018
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6BD6
| Crystal structure of human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl (2-{[(2S)-3-oxo-2-(phenylamino)-3-{[(pyridin-3-yl)methyl]amino}propyl]sulfanyl}ethyl)carbamate | 著者 | Sevrioukova, I. | 登録日 | 2017-10-21 | 公開日 | 2017-12-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Inhibition of Human CYP3A4 by Rationally Designed Ritonavir-Like Compounds: Impact and Interplay of the Side Group Functionalities. Mol Pharm., 15, 2018
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6BDI
| Crystal structure of human CYP3A4 bound to an inhibitor | 分子名称: | Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, tert-butyl [(2S)-1-(1H-indol-3-yl)-3-{[(2R)-3-oxo-2-[(propan-2-yl)amino]-3-{[(pyridin-3-yl)methyl]amino}propyl]sulfanyl}propan-2-yl]carbamate | 著者 | Sevrioukova, I. | 登録日 | 2017-10-23 | 公開日 | 2017-12-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Interaction of the rationally designed ritonavir-like inhibitors with human cytochrome P450 3A4: Impact of the side group interplay Mol. Pharm., 2017
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5WWE
| Crystal structure of hnRNPA2B1 in complex with RNA | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1, RNA (5'-R(*AP*GP*GP*GP*AP*CP*UP*AP*GP*A)-3') | 著者 | Wu, B.X, Su, S.C, Ma, J.B. | 登録日 | 2017-01-01 | 公開日 | 2018-01-17 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1. Nat Commun, 9, 2018
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4NWH
| Lysozyme UNDER 30 BAR PRESSURE OF XENON | 分子名称: | CHLORIDE ION, Lysozyme C, SODIUM ION, ... | 著者 | Colloc'h, N, Prange, T. | 登録日 | 2013-12-06 | 公開日 | 2014-09-24 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystallographic Studies with Xenon and Nitrous Oxide Provide Evidence for Protein-dependent Processes in the Mechanisms of General Anesthesia Anesthesiology, 121, 2014
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5WWW
| Crystal structure of the KH1 domain of human RNA-binding E3 ubiquitin-protein ligase MEX-3C complex with RNA | 分子名称: | RNA (5'-R(*GP*UP*UP*UP*AP*G)-3'), RNA-binding E3 ubiquitin-protein ligase MEX3C | 著者 | Yang, L, Wang, C, Li, F, Gong, Q. | 登録日 | 2017-01-05 | 公開日 | 2017-08-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity J. Biol. Chem., 292, 2017
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5WWZ
| Crystal structure of the KH2 domain of human RNA-binding E3 ubiquitin-protein ligase MEX-3C | 分子名称: | RNA-binding E3 ubiquitin-protein ligase MEX3C, SULFATE ION | 著者 | Yang, L, Wang, C, Li, F, Gong, Q. | 登録日 | 2017-01-05 | 公開日 | 2017-08-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity J. Biol. Chem., 292, 2017
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6EIM
| Human STK10 bound to GW683134A | 分子名称: | 1,2-ETHANEDIOL, Serine/threonine-protein kinase 10, ~{N}-[5-[4-[[2-fluoranyl-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1~{H}-benzimidazol-2-yl]furan-2-carboxamide | 著者 | Sorrell, F.J, Berger, B.-T, Salah, E, von Delft, F, Bountra, C, Arrowsmith, C, Edwards, A.M, Knapp, S, Elkins, J.M. | 登録日 | 2017-09-19 | 公開日 | 2017-11-01 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | Human STK10 bound to GW683134 To Be Published
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5WXF
| Crystal structure of uPA in complex with upain-2-2 | 分子名称: | SULFATE ION, Urokinase-type plasminogen activator chain B, upain-2-2 peptide | 著者 | Jiang, L, Huang, M. | 登録日 | 2017-01-07 | 公開日 | 2018-07-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | 主引用文献 | Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition. Biochim. Biophys. Acta, 1862, 2018
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