3P57
 
 | | Crystal structure of the p300 TAZ2 domain bound to MEF2 on DNA | | 分子名称: | DNA (5'-D(*A*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), Histone acetyltransferase p300, ... | | 著者 | He, J, Ye, J, Riquelme, C, Liu, J.O. | | 登録日 | 2010-10-08 | | 公開日 | 2011-08-10 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1921 Å) | | 主引用文献 | Structure of p300 bound to MEF2 on DNA reveals a mechanism of enhanceosome assembly.
Nucleic Acids Res., 39, 2011
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8OR2
 | | CAND1-CUL1-RBX1-DCNL1 | | 分子名称: | Cullin-1, Cullin-associated NEDD8-dissociated protein 1, DCN1-like protein 1, ... | | 著者 | Shaaban, M, Clapperton, J.A, Ding, S, Maeots, M.E, Enchev, R.I. | | 登録日 | 2023-04-12 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange.
Mol.Cell, 83, 2023
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1CQQ
 | | TYPE 2 RHINOVIRUS 3C PROTEASE WITH AG7088 INHIBITOR | | 分子名称: | 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, TYPE 2 RHINOVIRUS 3C PROTEASE | | 著者 | Matthews, D, Ferre, R.A. | | 登録日 | 1999-08-10 | | 公開日 | 1999-09-20 | | 最終更新日 | 2018-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.
Proc.Natl.Acad.Sci.USA, 96, 1999
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4FFZ
 | | Crystal Structure of DENV1-E111 fab fragment bound to DENV-1 DIII (Western Pacific-74 strain). | | 分子名称: | DENV1-E111 fab fragment (heavy chain), DENV1-E111 fab fragment (light chain), Envelope protein E | | 著者 | Austin, S.K, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2012-06-01 | | 公開日 | 2012-06-27 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural Basis of Differential Neutralization of DENV-1 Genotypes by an Antibody that Recognizes a Cryptic Epitope.
Plos Pathog., 8, 2012
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1PIV
 | | BINDING OF THE ANTIVIRAL DRUG WIN51711 TO THE SABIN STRAIN OF TYPE 3 POLIOVIRUS: STRUCTURAL COMPARISON WITH DRUG BINDING IN RHINOVIRUS 14 | | 分子名称: | 5-(7-(4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE, MYRISTIC ACID, POLIOVIRUS TYPE 3 (SUBUNIT VP1), ... | | 著者 | Hiremath, C.N, Grant, R.A, Filman, D.J, Hogle, J.M. | | 登録日 | 1995-02-02 | | 公開日 | 1995-06-03 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Binding of the antiviral drug WIN51711 to the sabin strain of type 3 poliovirus: structural comparison with drug binding in rhinovirus 14.
Acta Crystallogr.,Sect.D, 51, 1995
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5V8W
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1H6F
 | | Human TBX3, a transcription factor responsible for ulnar-mammary syndrome, bound to a palindromic DNA site | | 分子名称: | 5'-D(*TP*AP*AP*TP*TP*TP*CP*AP*CP*AP*CP*CP*TP* AP*GP*GP*TP*GP*TP*GP*AP*AP*AP*T)-3', MAGNESIUM ION, T-BOX TRANSCRIPTION FACTOR TBX3 | | 著者 | Coll, M, Muller, C.W. | | 登録日 | 2001-06-13 | | 公開日 | 2002-04-19 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structure of the DNA-Bound T-Box Domain of Human Tbx3, a Transcription Factor Responsible for Ulnar- Mammary Syndrome
Structure, 10, 2002
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8DL7
 | | Cryo-EM structure of human ferroportin/slc40 bound to minihepcidin PR73 in nanodisc | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 11F9 heavy-chain, 11F9 light-chain, ... | | 著者 | Shen, J, Wilbon, A.S, Pan, Y, Zhou, M. | | 登録日 | 2022-07-07 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural basis of ferroportin inhibition by minihepcidin PR73.
Plos Biol., 21, 2023
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8DL8
 | | Cryo-EM structure of human ferroportin/slc40 bound to Co2+ in nanodisc | | 分子名称: | 11F9 heavy-chain, 11F9 light-chain, COBALT (II) ION, ... | | 著者 | Shen, J, Wilbon, A.S, Pan, Y, Zhou, M. | | 登録日 | 2022-07-07 | | 公開日 | 2022-12-07 | | 最終更新日 | 2023-02-01 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis of ferroportin inhibition by minihepcidin PR73.
Plos Biol., 21, 2023
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6EKM
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2HWK
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5BT1
 | | histone chaperone Hif1 playing with histone H2A-H2B dimer | | 分子名称: | HAT1-interacting factor 1, Histone H2A.1, Histone H2B.1 | | 著者 | Liu, H, Zhang, M, Gao, Y, Teng, M, Niu, L. | | 登録日 | 2015-06-02 | | 公開日 | 2016-10-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Structural Insights into the Association of Hif1 with Histones H2A-H2B Dimer and H3-H4 Tetramer
Structure, 24, 2016
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7K3J
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7K3K
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8B52
 | | Usutu virus methyltransferase domain in complex with sinefungin | | 分子名称: | GLYCEROL, Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Ferrero, D.S, Albentosa Gonzalez, L, Mas, A, Verdaguer, N. | | 登録日 | 2022-09-21 | | 公開日 | 2023-10-04 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Structure and function of the NS5 methyltransferase domain from Usutu virus.
Antiviral Res., 208, 2022
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7NBV
 | | Structure of 2A protein from Theilers murine encephalomyelitis virus (TMEV) | | 分子名称: | BROMIDE ION, Capsid protein VP0 | | 著者 | Hill, C.H, Cook, G.M, Napthine, S, Kibe, A, Brown, K, Caliskan, N, Firth, A.E, Graham, S.C, Brierley, I. | | 登録日 | 2021-01-28 | | 公開日 | 2021-12-08 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus.
Nucleic Acids Res., 49, 2021
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1ATP
 | | 2.2 angstrom refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MNATP and a peptide inhibitor | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, PEPTIDE INHIBITOR PKI(5-24), ... | | 著者 | Zheng, J, Trafny, E.A, Knighton, D.R, Xuong, N.-H, Taylor, S.S, Teneyck, L.F, Sowadski, J.M. | | 登録日 | 1993-01-08 | | 公開日 | 1993-04-15 | | 最終更新日 | 2019-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | 2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor.
Acta Crystallogr.,Sect.D, 49, 1993
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3WE1
 | | Crystal structure of Dengue 4 Envelope protein domain III (ED3) | | 分子名称: | Envelope protein E | | 著者 | Elahi, M, Islam, M.M, Noguchi, K, Yohda, M, Toh, H, Kuroda, Y. | | 登録日 | 2013-06-27 | | 公開日 | 2014-01-22 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.278 Å) | | 主引用文献 | Computational prediction and experimental characterization of a "size switch type repacking" during the evolution of dengue envelope protein domain III (ED3).
Biochim.Biophys.Acta, 1844, 2014
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4L0Z
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5UKB
 | | VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004 | | 分子名称: | Anti-vesicular stomatitis virus N VHH, Nucleocapsid, RNA (45-MER) | | 著者 | Hanke, L, Knockenhauer, K.E, Ploegh, H.L, Schwartz, T.U. | | 登録日 | 2017-01-20 | | 公開日 | 2017-04-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (5.473 Å) | | 主引用文献 | Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.
EMBO Rep., 18, 2017
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4L0Y
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4L18
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5A00
 | | Structure of human PARP1 catalytic domain bound to an isoindolinone inhibitor | | 分子名称: | 2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide, POLY [ADP-RIBOSE] POLYMERASE 1, SULFATE ION | | 著者 | Casale, E, Fasolini, M, Papeo, G, Posteri, H, Borghi, D, Busel, A.A, Caprera, F, Ciomei, M, Cirla, A, Corti, E, DAnello, M, Fasolini, M, Felder, E.R, Forte, B, Galvani, A, Isacchi, A, Khvat, A, Krasavin, M.Y, Lupi, R, Orsini, P, Perego, R, Pesenti, E, Pezzetta, D, Rainoldi, S, RiccardiSirtori, F, Scolaro, A, Sola, F, Zuccotto, F, Donati, D, Montagnoli, A. | | 登録日 | 2015-04-15 | | 公開日 | 2015-08-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Discovery of 2-[1-(4,4-Difluorocyclohexyl)Piperidin-4-Yl]-6-Fluoro-3-Oxo-2,3-Dihydro-1H-Isoindole-4-Carboxamide (Nms-P118): A Potent, Orally Available and Highly Selective Parp- 1 Inhibitor for Cancer Therapy.
J.Med.Chem., 58, 2015
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3PY3
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4A92
 | | Full-length HCV NS3-4A protease-helicase in complex with a macrocyclic protease inhibitor. | | 分子名称: | (1'R,2R,2'S,6S,24AS)-17-FLUORO-6-(1-METHYL-2-OXOPIPERIDINE-3-CARBOXAMIDO)-19,19-DIOXIDO-5,21,24-TRIOXO-2'-VINYL-1,2,3,5,6,7,8,9,10,11,12,13,14,20,21,23,24,24A-OCTADECAHYDROSPIRO[BENZO[S]PYRROLO[2,1-G][1,2,5,8,18]THIATETRAAZACYCLOICOSINE-22,1'-CYCLOPRO-2-CARBOXYLATEPAN]-2-YL 4-FLUOROISOINDOLINE, SERINE PROTEASE NS3, ZINC ION | | 著者 | Schiering, N, D'Arcy, A, Simic, O, Eder, J, Raman, P, Svergun, D.I, Bodendorf, U. | | 登録日 | 2011-11-23 | | 公開日 | 2011-12-28 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | | 主引用文献 | A Macrocyclic Hcv Ns3/4A Protease Inhibitor Interacts with Protease and Helicase Residues in the Complex with its Full- Length Target.
Proc.Natl.Acad.Sci.USA, 108, 2011
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