PDB: 2682 件ウェブページステータス検索Chemie searchBIRD

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7UW1	A. baumannii 70S ribosome-Streptothricin-D complex 分子名称: 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ... 著者 Morgan, C.E, Yu, E.W. 登録日 2022-05-02 公開日 2023-04-19 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.21 Å) 主引用文献 Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome. Plos Biol., 21, 2023
8BHL	Elongating E. coli 70S ribosome containing acylated tRNA(iMet) in the P-site and Am6AA mRNA codon in the A-site after uncompleted di-peptide formation 分子名称: 16S rRNA RRSB-RRNA, 23S rRNA RRLG-RRNA, 30S ribosomal protein S10, ... 著者 Koziej, L, Glatt, S. 登録日 2022-10-31 公開日 2023-08-16 実験手法 ELECTRON MICROSCOPY (2.21 Å) 主引用文献 Modulation of translational decoding by m 6 A modification of mRNA. Nat Commun, 14, 2023
7UVZ	A. baumannii ribosome-Streptothricin-D complex: 70S with E-site tRNA 分子名称: 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ... 著者 Morgan, C.E, Yu, E.W. 登録日 2022-05-02 公開日 2023-04-19 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.21 Å) 主引用文献 Streptothricin F is a bactericidal antibiotic effective against highly drug-resistant gram-negative bacteria that interacts with the 30S subunit of the 70S ribosome. Plos Biol., 21, 2023
4RYP	Crystal Structure of T. Brucei Farnesyl Diphosphate Synthase 分子名称: Farnesyl pyrophosphate synthase 著者 Cao, R, Liu, Y.-L, Oldfield, E. 登録日 2014-12-16 公開日 2015-04-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. ACS Med Chem Lett, 6, 2015
7E78	the structure of cytosolic TaPGI with substrate 分子名称: 6-O-phosphono-alpha-D-glucopyranose, Glucose-6-phosphate isomerase 著者 Gao, F, Liu, C.M. 登録日 2021-02-25 公開日 2021-07-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Engineering of the cytosolic form of phosphoglucose isomerase into chloroplasts improves plant photosynthesis and biomass. New Phytol., 231, 2021
8P8U	Yeast 60S ribosomal subunit 分子名称: 25S rRNA, 5.8S rRNA, 5S rRNA, ... 著者 Rabl, J, Banerjee, A, Boehringer, D, Zavolan, M. 登録日 2023-06-02 公開日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.23 Å) 主引用文献 Yeast 60S ribosomal subunit To Be Published
3MTA	Glycogen phosphorylase complexed with 3-bromobenzaldehyde-4-(beta-D-glucopyranosyl)-thiosemicarbazone 分子名称: Glycogen phosphorylase, muscle form, N-({(2E)-2-[(3-bromophenyl)methylidene]hydrazino}carbonothioyl)-beta-D-glucopyranosylamine 著者 Alexacou, K.-M. 登録日 2010-04-30 公開日 2011-01-05 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors Bioorg.Med.Chem., 18, 2010
2ZEV	S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium, IPP and BPH-715 分子名称: 3-(DECYLOXY)-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Geranylgeranyl pyrophosphate synthetase, ... 著者 Guo, R.T, Chen, C.K.-M, Cao, R, Oldfield, E, Wang, A.H.-J. 登録日 2007-12-17 公開日 2008-12-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation J.Am.Chem.Soc., 131, 2009
1E1Y	Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site 分子名称: 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE, GLYCOGEN PHOSPHORYLASE, MUSCLE FORM, ... 著者 Oikonomakos, N.G, Zographos, S.E, Skamnaki, V.T, Tsitsanou, K.E, Johnson, L.N. 登録日 2000-05-11 公開日 2000-05-17 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Flavopiridol Inhibits Glycogen Phosphorylase by Binding at the Inhibitor Site J.Biol.Chem., 275, 2000
8EIU	E. coli 70S ribosome with A-loop mutations U2554C and U2555C 分子名称: 16S rRNA, 23S rRNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), ... 著者 Nissley, A.J, Penev, P.I, Watson, Z.L, Banfield, J.F, Cate, J.H.D. 登録日 2022-09-15 公開日 2023-02-01 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (2.24 Å) 主引用文献 Rare ribosomal RNA sequences from archaea stabilize the bacterial ribosome. Nucleic Acids Res., 51, 2023
5HN1	Crystal structure of Interleukin-37 分子名称: Interleukin-37, SULFATE ION 著者 Ellisdon, A.M, Nold-Petry, C.A, Nold, M.F, Whisstock, J.C. 登録日 2016-01-17 公開日 2017-02-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Homodimerization attenuates the anti-inflammatory activity of interleukin-37. Sci Immunol, 2, 2017
1VQP	The structure of the transition state analogue "RAP" bound to the large ribosomal subunit of haloarcula marismortui 分子名称: 23S ribosomal rna, 5'-R(*(DC)P*(DC)P*(PPU)*(LOF)P*(PO2)P*AP*C*C)-3', 50S RIBOSOMAL PROTEIN L10E, ... 著者 Schmeing, T.M, Steitz, T.A. 登録日 2004-12-16 公開日 2005-11-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural Insights into the Roles of Water and the 2' Hydroxyl of the P Site tRNA in the Peptidyl Transferase Reaction. Mol.Cell, 20, 2005
3VEY	glucokinase in complex with glucose and ATPgS 分子名称: 6-methoxy-N-(1-methyl-1H-pyrazol-3-yl)quinazolin-4-amine, Glucokinase, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Liu, S. 登録日 2012-01-09 公開日 2012-02-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Insights into Mechanism of Glucokinase Activation: OBSERVATION OF MULTIPLE DISTINCT PROTEIN CONFORMATIONS. J.Biol.Chem., 287, 2012
6EZB	Crystal Structure of human tRNA-dihydrouridine(20) synthase catalytic domain Q305K mutant 分子名称: FLAVIN MONONUCLEOTIDE, GLYCEROL, SULFATE ION, ... 著者 Bou-Nader, C, Bregeon, D, Pecqueur, L, Fontecave, M, Hamdane, D. 登録日 2017-11-14 公開日 2018-09-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Electrostatic Potential in the tRNA Binding Evolution of Dihydrouridine Synthases. Biochemistry, 57, 2018
3N6K	Human FPPS complex with NOV_823 分子名称: 1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid, FARNESYL PYROPHOSPHATE SYNTHASE, PHOSPHATE ION 著者 Rondeau, J.-M. 登録日 2010-05-26 公開日 2010-08-18 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. Nat.Chem.Biol., 6, 2010
8BZS	The crystal structure of glycogen phosphorylase in complex with baicalein 分子名称: 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one, Glycogen phosphorylase, muscle form, ... 著者 Koulas, S.M, Mathomes, R, Hayes, J.M, Leonidas, D.D. 登録日 2022-12-15 公開日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Multidisciplinary docking, kinetics and X-ray crystallography studies of baicalein acting as a glycogen phosphorylase inhibitor and determination of its' potential against glioblastoma in cellular models. Chem.Biol.Interact., 382, 2023
2WU8	Structural studies of phosphoglucose isomerase from Mycobacterium tuberculosis H37Rv 分子名称: GLUCOSE-6-PHOSPHATE ISOMERASE, SULFATE ION 著者 Anand, K. 登録日 2009-10-01 公開日 2009-10-27 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural Studies of Phosphoglucose Isomerase from Mycobacterium Tuberculosis H37Rv Acta Crystallogr.,Sect.F, 66, 2010
1QHA	HUMAN HEXOKINASE TYPE I COMPLEXED WITH ATP ANALOGUE AMP-PNP 分子名称: 6-O-phosphono-alpha-D-glucopyranose, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Rosano, C, Sabini, E, Deriu, D, Magnani, M, Bolognesi, M. 登録日 1999-05-11 公開日 1999-11-10 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control. Structure Fold.Des., 7, 1999
1L5Q	Human liver glycogen phosphorylase a complexed with caffeine, N-Acetyl-beta-D-glucopyranosylamine, and CP-403700 分子名称: CAFFEINE, Glycogen phosphorylase, liver form, ... 著者 Ekstrom, J.L, Pauly, T.A, Carty, M.D, Soeller, W.C, Culp, J, Danley, D.E, Hoover, D.J, Treadway, J.L, Gibbs, E.M, Fletterick, R.J, Day, Y.S.N, Myszka, D.G, Rath, V.L. 登録日 2002-03-07 公開日 2002-12-04 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase. Chem.Biol., 9, 2002
1WUT	Acyl Ureas as Human Liver Glycogen Phosphorylase Inhibitors for the Treatment of Type 2 Diabetes 分子名称: 7-[2,6-DICHLORO-4-({[(2-CHLOROBENZOYL)AMINO]CARBONYL}AMINO)PHENOXY]HEPTANOIC ACID, Glycogen phosphorylase, muscle form, ... 著者 Klabunde, T, Wendt, K.U, Kadereit, D, Brachvogel, V, Burger, H.-J, Herling, A.W, Oikonomakos, N.G, Kosmopoulou, M.N, Schmoll, D, Sarubbi, E, von Roedern, E, Schonafinger, K, Defossa, E. 登録日 2004-12-08 公開日 2005-12-08 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs Protein Sci., 14, 2005
1WV0	Crystallographic studies on acyl ureas, a new class of inhibitors of glycogen phosphorylase. Broad specificity of the allosteric site 分子名称: 4-[4-({[(2,4-DICHLOROBENZOYL)AMINO]CARBONYL}AMINO)-2,3-DIMETHYLPHENOXY]BUTANOIC ACID, Glycogen phosphorylase, muscle form, ... 著者 Oikonomakos, N.G, Kosmopoulou, M.N, Chrysina, E.D, Leonidas, D.D, Klabunde, T, Wendt, K.U, Defossa, E. 登録日 2004-12-10 公開日 2005-12-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs Protein Sci., 14, 2005
1WV1	Crystallographic studies on acyl ureas, a new class of inhibitors of glycogenphosphorylase. Broad specificity of the allosteric site 分子名称: 5-[3-({[(2,4-DICHLOROBENZOYL)AMINO]CARBONYL}AMINO)-2-METHYLPHENOXY]PENTANOIC ACID, Glycogen phosphorylase, muscle form, ... 著者 Oikonomakos, N.G, Kosmopoulou, M.N, Chrysina, E.D, Leonidas, D.D, Klabunde, T, Wendt, K.U, Defossa, E. 登録日 2004-12-10 公開日 2005-12-10 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs Protein Sci., 14, 2005
1WUY	Crystallographic studies on acyl ureas, a new class of inhibitors of glycogen phosphorylase. Broad specificity of the allosteric site 分子名称: 4-[3-CHLORO-4-({[(2,4-DICHLOROBENZOYL)AMINO]CARBONYL}AMINO)PHENOXY]BUTANOIC ACID, Glycogen phosphorylase, muscle form, ... 著者 Oikonomakos, N.G, Kosmopoulou, M.N, Chrysina, E.D, Leonidas, D.D, Klabunde, T, Wendt, K.U, Defossa, E. 登録日 2004-12-09 公開日 2005-12-09 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs Protein Sci., 14, 2005
1K08	Crystallographic Binding Study of 10 mM N-benzoyl-N'-beta-D-glucopyranosyl urea to glycogen phosphorylase b 分子名称: Glycogen Phosphorylase, N-[(phenylcarbonyl)carbamoyl]-beta-D-glucopyranosylamine, PYRIDOXAL-5'-PHOSPHATE 著者 Oikonomakos, N.G, Kosmopoulou, M, Zographos, S.E, Leonidas, D.D, Chrysina, E.D, Somsak, L, Nagy, V, Praly, J.P, Docsa, T, Toth, B, Gergely, P. 登録日 2001-09-18 公開日 2001-10-03 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Binding of N-acetyl-N '-beta-D-glucopyranosyl urea and N-benzoyl-N '-beta-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies. Eur.J.Biochem., 269, 2002
1HLF	BINDING OF GLUCOPYRANOSYLIDENE-SPIRO-THIOHYDANTOIN TO GLYCOGEN PHOSPHORYLASE B: KINETIC AND CRYSTALLOGRAPHIC STUD 分子名称: (5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one, GLYCOGEN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE 著者 Oikonomakos, N.G, Skamnaki, V.T, Docsa, T, Toth, B, Gergely, P, Osz, E, Szilagyi, L, Somsak, L. 登録日 2000-12-01 公開日 2000-12-13 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B BIOORG.MED.CHEM., 10, 2002

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