1YZT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1yzt by Molmil](/molmil-images/mine/1yzt) | GppNHp-Bound Rab21 GTPase at 2.05 A Resolution | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-21 | 著者 | Eathiraj, S, Pan, X, Ritacco, C, Lambright, D.G. | 登録日 | 2005-02-28 | 公開日 | 2005-07-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Nature, 436, 2005
|
|
2HT6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ht6 by Molmil](/molmil-images/mine/2ht6) | |
2EW1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ew1 by Molmil](/molmil-images/mine/2ew1) | Crystal Structure of Rab30 in complex with a GTP analogue | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-30 | 著者 | Wang, J, Shen, Y, Ismail, S, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Bochkarev, A, Park, H.W, Structural Genomics Consortium (SGC) | 登録日 | 2005-11-01 | 公開日 | 2005-11-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of RAB30 in complex with a GTP analogue To be Published
|
|
2ERY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ery by Molmil](/molmil-images/mine/2ery) | The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein R-Ras2 | 著者 | Salah, E, Schoch, G, Turnbull, A, Papagrigoriou, E, Soundararajan, M, Burgess, N, Elkins, J, Gileadi, C, Gileadi, O, von Delft, F, Edwards, A, Arrowsmith, C, Weigelt, J, Sundstrom, M, Doyle, D, Structural Genomics Consortium (SGC) | 登録日 | 2005-10-25 | 公開日 | 2005-11-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state To be Published
|
|
2ERX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2erx by Molmil](/molmil-images/mine/2erx) | Crystal Structure of DiRas2 in Complex With GDP and Inorganic Phosphate | 分子名称: | GTP-binding protein Di-Ras2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Papagrigoriou, E, Yang, X, Elkins, J, Niesen, F.E, Burgess, N, Salah, E, Fedorov, O, Ball, L.J, von Delft, F, Sundstrom, M, Edwards, A, Arrowsmith, C, Weigelt, J, Doyle, D. | 登録日 | 2005-10-25 | 公開日 | 2005-11-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Crystal Structure of DiRas2 To be Published
|
|
2EVW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2evw by Molmil](/molmil-images/mine/2evw) | |
5UFE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ufe by Molmil](/molmil-images/mine/5ufe) | |
5UB8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ub8 by Molmil](/molmil-images/mine/5ub8) | Crystal structure of YPT31, a Rab family GTPase from Candida albicans, in complex with GDP and Zn(II) | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Likely rab family GTP-binding protein, ZINC ION | 著者 | Stogios, P.J, Skarina, T, Di Leo, R, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2016-12-20 | 公開日 | 2017-01-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Crystal structure of YPT31, a Rab family GTPase from Candida albicans, in complex with GDP and Zn(II) To Be Published
|
|
5UFQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ufq by Molmil](/molmil-images/mine/5ufq) | K-RasG12D(GNP)/R11.1.6 complex | 分子名称: | CADMIUM ION, CALCIUM ION, CHLORIDE ION, ... | 著者 | Parker, J.A, Mattos, C. | 登録日 | 2017-01-05 | 公開日 | 2017-08-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | 主引用文献 | An engineered protein antagonist of K-Ras/B-Raf interaction. Sci Rep, 7, 2017
|
|
5UHV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5uhv by Molmil](/molmil-images/mine/5uhv) | wild-type NRas bound to GppNHp | 分子名称: | GLYCEROL, GTPase NRas, MAGNESIUM ION, ... | 著者 | Reid, D, Johnson, C, Salter, S, Mattos, C. | 登録日 | 2017-01-12 | 公開日 | 2017-06-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.672 Å) | 主引用文献 | The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects. J. Biol. Chem., 292, 2017
|
|
5V6V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5v6v by Molmil](/molmil-images/mine/5v6v) | Crystal structure of small molecule aziridine 3 covalently bound to K-Ras G12C | 分子名称: | 3-amino-1-{4-[6-chloro-8-fluoro-7-(5-methyl-1H-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... | 著者 | McGregor, L.M, Jenkins, M, Kerwin, C, Burke, J.E, Shokat, K.M. | 登録日 | 2017-03-17 | 公開日 | 2017-06-28 | 最終更新日 | 2019-11-20 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes. Biochemistry, 56, 2017
|
|
5V6S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5v6s by Molmil](/molmil-images/mine/5v6s) | Crystal structure of small molecule acrylamide 1 covalently bound to K-Ras G12C | 分子名称: | 1-{4-[6-chloro-8-fluoro-7-(5-methyl-1H-indazol-4-yl)quinazolin-4-yl]piperazin-1-yl}propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | McGregor, L.M, Jenkins, M, Kerwin, C, Burke, J.E, Shokat, K.M. | 登録日 | 2017-03-17 | 公開日 | 2017-06-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes. Biochemistry, 56, 2017
|
|
5UK9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5uk9 by Molmil](/molmil-images/mine/5uk9) | Wild-type K-Ras(GCP) pH 6.5 | 分子名称: | GLYCEROL, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Parker, J.A, Mattos, C. | 登録日 | 2017-01-20 | 公開日 | 2018-01-10 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.887 Å) | 主引用文献 | K-Ras Populates Conformational States Differently from Its Isoform H-Ras and Oncogenic Mutant K-RasG12D. Structure, 26, 2018
|
|
5VBE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vbe by Molmil](/molmil-images/mine/5vbe) | Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GDP | 分子名称: | 1-(4-methoxyphenyl)-N-(3-sulfanylpropyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide, GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Gentile, D.R, Jenkins, M.L, Moss, S.M, Burke, J.E, Shokat, K.M. | 登録日 | 2017-03-29 | 公開日 | 2017-10-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell Chem Biol, 24, 2017
|
|
5W22
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5w22 by Molmil](/molmil-images/mine/5w22) | Crystal structure of human WT-KRAS in complex with GDP | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | 著者 | Xu, S, Long, B, Boris, G, Ni, S, Kennedy, M.A. | 登録日 | 2017-06-05 | 公開日 | 2017-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.762 Å) | 主引用文献 | Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras. Acta Crystallogr D Struct Biol, 73, 2017
|
|
5VQ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vq0 by Molmil](/molmil-images/mine/5vq0) | Crystal structure of human KRAS G12A mutant in complex with GDP (EDTA soaked) | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | 著者 | Xu, S, Long, B, Boris, G, Ni, S, Kennedy, M.A. | 登録日 | 2017-05-06 | 公開日 | 2017-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras. Acta Crystallogr D Struct Biol, 73, 2017
|
|
5VQ6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vq6 by Molmil](/molmil-images/mine/5vq6) | Crystal structure of human WT-KRAS in complex with GTP-gamma-S | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase KRas, MAGNESIUM ION | 著者 | Xu, S, Long, B, Boris, G, Ni, S, Kennedy, M.A. | 登録日 | 2017-05-08 | 公開日 | 2017-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras. Acta Crystallogr D Struct Biol, 73, 2017
|
|
5VP7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vp7 by Molmil](/molmil-images/mine/5vp7) | Crystal structure of human KRAS G12A mutant in complex with GDP | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Xu, S, Long, B, Boris, G, Chen, A, Ni, S, Kennedy, M.A. | 登録日 | 2017-05-04 | 公開日 | 2017-12-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras. Acta Crystallogr D Struct Biol, 73, 2017
|
|
5VPZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vpz by Molmil](/molmil-images/mine/5vpz) | Crystal structure of human KRAS G12A mutant in complex with GTP-gamma-S | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, GTPase KRas, MAGNESIUM ION | 著者 | Xu, S, Long, B, Boris, G, Ni, S, Kennedy, M.A. | 登録日 | 2017-05-06 | 公開日 | 2017-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras. Acta Crystallogr D Struct Biol, 73, 2017
|
|
5VQ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vq1 by Molmil](/molmil-images/mine/5vq1) | Crystal structure of human KRAS Q61A mutant in complex with GDP | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Xu, S, Long, B, Boris, G, Ni, S, Kennedy, M.A. | 登録日 | 2017-05-07 | 公開日 | 2017-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras. Acta Crystallogr D Struct Biol, 73, 2017
|
|
5USJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5usj by Molmil](/molmil-images/mine/5usj) | Crystal Structure of human KRAS G12D mutant in complex with GDPNP | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Huang, C.S, Kaplan, A, Stockwell, B.R, Tong, L. | 登録日 | 2017-02-13 | 公開日 | 2017-03-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Multivalent Small-Molecule Pan-RAS Inhibitors. Cell, 168, 2017
|
|
5VPI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vpi by Molmil](/molmil-images/mine/5vpi) | Crystal structure of human KRAS G12A mutant in complex with GTP | 分子名称: | GTPase KRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | 著者 | Xu, S, Long, B, Boris, G, Ni, S, Kennedy, M.A. | 登録日 | 2017-05-05 | 公開日 | 2017-12-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras. Acta Crystallogr D Struct Biol, 73, 2017
|
|
5WDO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5wdo by Molmil](/molmil-images/mine/5wdo) | H-Ras bound to GMP-PNP at 277K | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | 著者 | Cofsky, J.C, Bandaru, P, Gee, C.L, Kuriyan, J. | 登録日 | 2017-07-05 | 公開日 | 2017-07-19 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
|
|
5V9U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5v9u by Molmil](/molmil-images/mine/5v9u) | Crystal Structure of small molecule ARS-1620 covalently bound to K-Ras G12C | 分子名称: | (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... | 著者 | Janes, M.R, Zhang, J, Li, L.-S, Hansen, R, Peters, U, Guo, X, Chen, Y, Babbar, A, Firdaus, S.J, Feng, J, Chen, J.H, Li, S, Brehmer, D, Darjania, L, Li, S, Long, Y.O, Thach, C, Liu, Y, Zarieh, A, Ely, T, Kucharski, J.M, Kessler, L.V, Wu, T, Wang, Y, Yao, Y, Deng, X, Zarrinkar, P, Dashyant, D, Lorenzi, M.V, Hu-Lowe, D, Patricelli, M.P, Ren, P, Liu, Y. | 登録日 | 2017-03-23 | 公開日 | 2018-02-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell, 172, 2018
|
|
5VBZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5vbz by Molmil](/molmil-images/mine/5vbz) | Crystal Structure of Small Molecule Disulfide 2C07 Bound to H-Ras M72C GppNHp | 分子名称: | 1-(4-methoxyphenyl)-N-(3-sulfanylpropyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide, GTPase HRas, MAGNESIUM ION, ... | 著者 | Gentile, D.R, Jenkins, M.L, Moss, S.M, Burke, J.E, Shokat, K.M. | 登録日 | 2017-03-30 | 公開日 | 2017-10-25 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell Chem Biol, 24, 2017
|
|