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5V6S

Crystal structure of small molecule acrylamide 1 covalently bound to K-Ras G12C

Summary for 5V6S
Entry DOI10.2210/pdb5v6s/pdb
Related5v6v
DescriptorGTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsk-ras g12c, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight20273.20
Authors
McGregor, L.M.,Jenkins, M.,Kerwin, C.,Burke, J.E.,Shokat, K.M. (deposition date: 2017-03-17, release date: 2017-06-28, Last modification date: 2023-10-04)
Primary citationMcGregor, L.M.,Jenkins, M.L.,Kerwin, C.,Burke, J.E.,Shokat, K.M.
Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes.
Biochemistry, 56:3178-3183, 2017
Cited by
PubMed: 28621541
DOI: 10.1021/acs.biochem.7b00271
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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