5V6S
Crystal structure of small molecule acrylamide 1 covalently bound to K-Ras G12C
Summary for 5V6S
Entry DOI | 10.2210/pdb5v6s/pdb |
Related | 5v6v |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | k-ras g12c, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 20273.20 |
Authors | McGregor, L.M.,Jenkins, M.,Kerwin, C.,Burke, J.E.,Shokat, K.M. (deposition date: 2017-03-17, release date: 2017-06-28, Last modification date: 2023-10-04) |
Primary citation | McGregor, L.M.,Jenkins, M.L.,Kerwin, C.,Burke, J.E.,Shokat, K.M. Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes. Biochemistry, 56:3178-3183, 2017 Cited by PubMed: 28621541DOI: 10.1021/acs.biochem.7b00271 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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